Vitamin K in hand osteoarthritis: Results from a randomised clinical trial

Annals of the Rheumatic Diseases

Volumn 67, Issue 11, 2008, Pages 1570-1573

  Neogi, T ^a,d   Felson, D T ^a   Sarno, R ^b   Booth, S L ^c  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c TUFTS UNIVERSITY   (United States)

^d Clinical Epidemiology Unit   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; PHYTOMENADIONE; PLACEBO; VITAMIN D;

ADULT; AGED; ARTICLE; BLOOD VESSEL CALCIFICATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HAND DISEASE; HAND OSTEOARTHRITIS; HAND RADIOGRAPHY; HUMAN; IMAGE ANALYSIS; JOINT CAVITY; MAJOR CLINICAL STUDY; MALE; OSTEOARTHRITIS; OSTEOLYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

AGED; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HAND JOINTS; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS; VITAMIN K 1; VITAMIN K DEFICIENCY;

EID: 54349124629     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2008.094771     Document Type: Article

References (15)

1. Hale JE, Fraser JD, Price PA. The identification of matrix Gla protein in cartilage. J Biol Chem 1988;263:5820-4.
2. Price PA. Gla-containing proteins of bone. Connect Tissue Res 1989;21:51-7;discussion 57-60.
3. Booth SL, Suttie JW. Dietary intake and adequacy of vitamin K. J Nutr 1998;128:785-8.
4. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 1997;386:78-81.
5. Price PA, Williamson MK, Haba T, Dell RB, Jee WS. Excessive mineralization with growth plate closure in rats on chronic warfarin treatment. Proc Natl Acad Sci USA 1982;79:7734-8.
6. Neogi T, Booth SL, Zhang YQ, Jacques PF, Terkeltaub R, Aliabadi P, et al. Low vitamin K status is associated with osteoarthritis in the hand and knee. Arthritis Rheum 2006;54:1255-61.
7. Booth SL, Dallal G, Shea MK, Gundberg C, Peterson JW, Dawson-Huges B. Effect of Vitamin K supplementation on bone loss in elderly men and women. J Clin Endocrinol Metab 2008;93:1217-23.
8. Nevitt MC, Felson DT, Williams EN, Grady D. The effect of estrogen plus progestin on knee symptoms and related disability in postmenopausal women: the Heart and Estrogen/Progestin Replacement Study, a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2001;44:811-18.
9. Bischoff-Ferrari HA, Dawson-Hughes B. Where do we stand on vitamin D? Bone 2007;41:S13-19.
10. Loeser RF, Varnum BC, Carlson CS, Goldring MB, Liu ET, Sadiev S, et al. Human chondrocyte expression of growth-arrest-specific gene 6 and the tyrosine kinase receptor axl: potential role in autocrine signaling in cartilage. Arthritis Rheum 1997;40:1455-65.
11. Shea MK, Booth SL, Massaro JM, Jacques PF, D'Agostino Sr RB, Dawson-Hughes B, et al. Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol 2008;167:313-20.
12. Yagami K, Suh JY, Enomoto-Iwamoto M, Koyama E, Abrams WR, Shapiro IM, et al. Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb. J Cell Biol 1999;147:1097-108.
13. Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 2006;166:1256-61.
14. McAlindon TE, Felson DT, Zhang Y, Hannan MT, Aliabadi P, Weissman B, et al. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study. Ann Intern Med 1996;125:353-9.
15. IOM. Dietary reference intakes for vitamin A, vitamin K arsenic boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press, 2001.