Medical management of early pregnancy failure: Efficacy

Seminars in Reproductive Medicine

Volumn 26, Issue 5, 2008, Pages 411-422

  Chen, Beatrice A ^a,c   Creinin, Mitchell D ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Early pregnancy failure; Mifepristone; Miscarriage; Misoprostol; Missed abortion

Indexed keywords

MIFEPRISTONE; MISOPROSTOL; PLACEBO;

ABDOMINAL PAIN; CLINICAL TRIAL; DIARRHEA; DILATION AND EVACUATION; DRUG DOSE COMPARISON; DRUG EFFICACY; FIRST TRIMESTER PREGNANCY; HUMAN; INTERMETHOD COMPARISON; NAUSEA; PATIENT CARE; PREGNANCY DISORDER; REPEATED DRUG DOSE; REVIEW; SINGLE DRUG DOSE; VACUUM ASPIRATION; VOMITING;

ABORTIFACIENT AGENTS; ABORTION, SPONTANEOUS; FEMALE; HUMANS; MIFEPRISTONE; MISOPROSTOL; PREGNANCY; PREGNANCY TRIMESTER, FIRST; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 54349123539     PISSN: 15268004     EISSN: 15264564     Source Type: Journal    
DOI: 10.1055/s-0028-1087107     Document Type: Review

References (46)

1. Hemminki E. Treatment of miscarriage: current practice and rationale. Obstet Gynecol 1998;91:247-253
2. Warburton D, Fraser FC. Spontaneous abortion risks in man: data from reproductive histories collected in a medical genetics unit. Am J Hum Genet 1964;16:1-25
3. Creinin MD, Schwartz JL, Guido RS, Pymar HC. Early pregnancy failure-current management concepts. Obstet Gynecol Surv 2001;56:105-113
4. Creinin MD, Moyer R, Guido R. Misoprostol for medical evacuation of early pregnancy failure. Obstet Gynecol 1997; 89(5 Pt 1):768-772
5. Gronlund A, Gronlund L, Clevin L, et al. Management of missed abortion: comparison of medical treatment with either mifepristone+misoprostol or misoprostol alone with surgical evacuation. A multi-center trial in Copenhagen county, Denmark. Acta Obstet Gynecol Scand 2002;81:1060-1065
6. Bagratee JS, Khullar V, Regan L, Moodley J, Kagoro H. A randomized controlled trial comparing medical and expectant management of first trimester miscarriage. Hum Reprod 2004;19:266-271
7. Zalányi S. Vaginal misoprostol alone is effective in the treatment of missed abortion. Br J Obstet Gynaecol 1998;105:1026-1028
8. Zhang J, Gilles JM, Barnhart K, et al. A comparison of medical management with misoprostol and surgical management for early pregnancy failure. N Engl J Med 2005;353:761-769
9. Creinin MD. Medical abortion regimens: historical context and overview. Am J Obstet Gynecol 2000;183(2, Suppl):S3-S9
10. Nielsen S, Hahlin M. Expectant management of first-trimester spontaneous abortion. Lancet 1995;345:84-86
11. Callen PW. Ultrasonography in Obstetrics and Gynecology. 4th ed. Philadelphia, PA: WB Saunders; 2000
12. Harwood B, Meckstroth KR, Mishell DR, Jain JK. Serum beta-human chorionic gonadotropin levels and endometrial thickness after medical abortion. Contraception 2001;63:255-256
13. Reynolds A, Ayres-de-Campos D, Costa MA, Montenegro N. How should success be defined when attempting medical resolution of first-trimester missed abortion? Eur J Obstet Gynecol Reprod Biol 2005;118:71-76
14. Creinin MD, Harwood B, Guido RS, et al. Endometrial thickness after misoprostol use for early pregnancy failure. Int J Gynaecol Obstet 2004;86:22-26
15. Luise C, Jermy K, Collons WP, Bourne TH. Expectant management of incomplete, spontaneous first-trimester miscarriage: outcome according to initial ultrasound criteria and value of follow-up visits. Ultrasound Obstet Gynecol 2002;19:580-582
16. Reeves MF, Lohr PA, Harwood BJ, Creinin MD. Ultrasonographic endometrial thickness after medical and surgical management of early pregnancy failure. Obstet Gynecol 2008;111:106-112
17. Cowett AA, Cohen LS, Lichtenberg ES, Stika CS. Ultrasound evaluation of the endometrium after medical termination of pregnancy. Obstet Gynecol 2004;103(5 Pt 1):871-875
18. Ngoc NTN, Blum J, Westheimer E, Quan TTV, Winikoff B. Medical treatment of missed abortion using misoprostol. Int J Gynaecol Obstet 2004;87:138-142
19. Gilles JM, Creinin MD, Barnhart K, et al. A randomized trial of saline solution-moistened misoprostol versus dry misoprostol for first-trimester pregnancy failure. Am J Obstet Gynecol 2004;190:389-394
20. Tang OS, Lau WNT, Ng EHY, Lee SWH, Ho PC. A prospective randomized study to compare the use of repeated doses of vaginal with sublingual misoprostol in the management of first trimester silent miscarriages. Hum Reprod 2003;18:176-181
21. Tang OS, Ong CYT, Tse KY, et al. A randomized trial to compare the use of sublingual misoprostol with or without an additional 1 week course for the management of first trimester silent miscarriage. Hum Reprod 2006;21:189-192
22. Phupong V, Taneepanichskul S, Kriengsinyot R, et al. Comparative study between single dose 600 microg and repeated dose of oral misoprostol for treatment of incomplete abortion. Contraception 2004;70:307-311
23. Nguyen TN, Blum J, Durocher J, Quan TTV, Winikoff B. A randomized controlled study comparing 600 versus 1,200 mg oral misoprostol for medical management of incomplete abortion. Contraception 2005;72:438-442
24. Wood SL, Brain PH. Medical management of missed abortion: a randomized clinical trial. Obstet Gynecol 2002;99:563-566
25. Blohm F, Friden BE, Milsom I, Platz-Christensen JJ, Nielsen S. A randomised double blind trial comparing misoprostol or placebo in the management of early miscarriage. BJOG 2005;112:1090-1095
26. Weeks A, Alia G, Blum J, et al. A randomized trial of misoprostol compared with manual vacuum aspiration for incomplete abortion. Obstet Gynecol 2005;106:540-547
27. Bique C, Ustá M, Debora B, et al. Comparison of misoprostol and manual vacuum aspiration for the treatment of incomplete abortion. Int J Gynaecol Obstet 2007;98:222-226
28. Shwekerela B, Kalumuna R, Kipingili R, et al. Misoprostol for treatment of incomplete abortion at the regional hospital level: results from Tanzania. [see comment] BJOG 2007;114:1363-1367
29. Demetroulis C, Saridogan E, Kunde D, Naftalin AA. A prospective randomized control trial comparing medical and surgical treatment for early pregnancy failure. Hum Reprod 2001;16:365-369
30. Muffley PE, Stitely ML, Gherman RB. Early intrauterine pregnancy failure: a randomized trial of medical versus surgical treatment. Am J Obstet Gynecol 2002;187:321-325
31. Graziosi GCM, Mol BWJ, Reuwer PJH, Drogtrop A, Bruinse HW. Misoprostol versus curettage in women with early pregnancy failure after initial expectant management: a randomized trial. Hum Reprod 2004;19:1894-1899
32. Creinin MD, Huang X, Westhoff C, et al. Factors related to successful misoprostol treatment for early pregnancy failure. Obstet Gynecol 2006;107:901-907
33. Asch RH, Weckstein LN, Balmaceda JP, et al. Non-surgical expulsion of non-viable early pregnancy: a new application of RU 486. Hum Reprod 1990;5:481-483
34. Nielsen S, Hahlin M, Platz-Christensen JJ. Unsuccessful treatment of missed abortion with a combination of an antiprogesterone and a prostaglandin E1 analogue. Br J Obstet Gynaecol 1997;104:1094-1096
35. Coughlin LB, Roberts D, Haddad NG, Long A. Medical management of first trimester miscarriage (blighted ovum and missed abortion): is it effective? J Obstet Gynaecol 2004;24:69-71
36. Wagaarachchi PT, Ashok PW, Narvekar N, Smith NC, Templeton A. Medical management of early fetal demise using a combination of mifepristone and misoprostol. Hum Reprod 2001;16:1849-1853
37. Schaff EA, Fielding SL, Eisinger SH, Stadalius LS, Fuller L. Low-dose mifepristone followed by vaginal misoprostol at 48 hours for abortion up to 63 days. Contraception 2000;61:41-46
38. Creinin MD, Fox MC, Teal S, et al. A randomized comparison of misoprostol 6 to 8 hours versus 24 hours after mifepristone for abortion. Obstet Gynecol 2004;103(5 Pt 1): 851-859
39. Lelaidier C, Baton-Saint-Mleux C, Fernandez H, Bourget P, Frydman R. Mifepristone (RU 486) induces embryo expulsion in first trimester non-developing pregnancies: a prospective randomized trial. Hum Reprod 1993;8:492-495
40. Nielsen S, Hahlin M, Platz-Christensen J. Randomised trial comparing expectant with medical management for first trimester miscarriages. Br J Obstet Gynaecol 1999;106:804-807
41. Stockheim D, Machtinger R, Wiser A, et al. A randomized prospective study of misoprostol or mifepristone followed by misoprostol when needed for the treatment of women with early pregnancy failure. Fertil Steril 2006;86:956-960
42. Niinimäki M, Jouppila P, Martikainen H, Talvensaari-Mattila A. A randomized study comparing efficacy and patient satisfaction in medical or surgical treatment of miscarriage. Fertil Steril 2006;86:367-372
43. Schreiber CA, Creinin MD, Reeves MF, Harwood BJ. Mifepristone and misoprostol for the treatment of early pregnancy failure: a pilot clinical trial. Contraception 2006;74:458-462
44. Trinder J, Brocklehurst P, Porter R, et al. Management of miscarriage: expectant, medical, or surgical? Results of randomised controlled trial (miscarriage treatment [MIST] trial). BMJ 2006;332:1235-1240
45. Shelley JM, Healy D, Grover S. A randomised trial of surgical, medical and expectant management of first trimester spontaneous miscarriage. Aust N Z J Obstet Gynaecol 2005;45:122-127
46. Grwnlund L, Grwnlund A-L, Clevin L, et al. Spontaneous abortion: expectant management, medical treatment or surgical evacuation. Acta Obstet Gynecol Scand 2002;81:781-782