N-methyl scanning mutagenesis generates protease-resistant G protein ligands with improved affinity and selectivity

ChemBioChem

Volumn 9, Issue 14, 2008, Pages 2200-2203

  Fiacco, Stephen V ^a   Roberts, Richard W ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Medicinal chemistry; mRNA display; Mutagenesis; Peptidomimetics; Proteolysis

Indexed keywords

COMPLEMENTARY DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; PEPTIDE DERIVATIVE; PROTEINASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN METHYLATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTEIN STABILITY; PROTEIN SYNTHESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; GTP-BINDING PROTEINS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; OLIGOPEPTIDES; PEPTIDE HYDROLASES; PROTEIN BINDING; PROTEIN ENGINEERING; SUBSTRATE SPECIFICITY;

EID: 54349117981     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200800208     Document Type: Article

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