Intestinal microflora and immunoregulation

Mucosal Immunology

Volumn 1, Issue , 2008, Pages 47-49

  Boirivant, M ^a   Amendola, A ^a   Butera, A ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BACTERIAL ANTIGEN; PROBIOTIC AGENT;

BACTERIAL FLORA; COLITIS; COMMENSAL; CROSS REACTION; ENTERITIS; EXPERIMENTAL MODEL; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; INNATE IMMUNITY; INTESTINE FLORA; INTESTINE MUCOSA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

ANIMALS; COLITIS; HUMANS; INTESTINAL MUCOSA; LIPOPOLYSACCHARIDES; PROBIOTICS;

EID: 54349095456     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2008.52     Document Type: Article

References (10)

1. Strober, W., Fuss, I., Boirivant, M. & Kitani, A. Insights into the mechanism of oral tolerance derived from the study of models of mucosal inflammation. Ann. NY Acad. Sci. 1029, 115-131 (2004).
2. Podolsky, D. K. Inflammatory bowel disease. N. Engl. J. Med. 347, 417-429 (2002).
3. Duchmann, R., Kaiser, I., Hermann, E., Mayet, W., Ewe, K. & Meyer zum Buschenfelde, K. H. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin. Exp. Immunol. 102, 448-455 (1995).
4. Neurath, M. F., Fuss, I., Kelsall, B. L. & Strober, W. Experimental granulomatous colitis in mice is abrogated by induction of TGF-betamediated oral tolerance. J. Exp. Med. 183, 2605-2616 (1996).
5. Fuss, I. J., Boirivant, M., Lacy, B. & Strober, W. The interrelated roles of TGF-β and IL-10 in the regulation of experimental colitis. J. Immunol. 168, 900-908 (2002).
6. Boirivant, M., Strober, W. & Fuss, I. J. Regulatory cells induced by feeding TNP-Haptenated colonic protein cross-protect mice from colitis induced by an unrelated hapten. Inflamm. Bowel Dis. 11, 48-55 (2005).
7. Boirivant, M. et al. Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis. Gastroenterology 131, 1786-1798 (2006).
8. Di Giacinto, C., Marinaro, M., Sanchez, M., Strober, W. & Boirivant, M. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-β-bearing regulatory cells. J. Immunol. 174, 3237-3246 (2005).
9. Oida, T. et al. CD4+CD25 − T cells that express latency-associated peptide on the surface suppress CD4+CD45Rbhigh-induced colitis by a TGF-β-dependent mechanism. J. Immunol. 170, 2516-2522 (2003).
10. Pronio, A. et al. Probiotic administration in patients with ileal pouch-anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells. Inflamm. Bowel Dis. 14, 662-668 (2008).