Beneficial effects of oral tilactase on patients with hypolactasia

European Journal of Clinical Investigation

Volumn 38, Issue 11, 2008, Pages 835-844

  Portincasa, P ^a   Di Ciaula, A ^a   Vacca, M ^a   Montelli, R ^a   Wang, D Q H ^b,c   Palasciano, G ^a  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

Breath test; Lactase; Milk

Indexed keywords

BETA GALACTOSIDASE; HYDROGEN; LACDIGEST; LACTOSE; LACTULOSE; PLACEBO; TILACTASE; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ABSENCE OF SIDE EFFECTS; ADULT; AREA UNDER THE CURVE; ARTICLE; BLOATING; CONTROLLED STUDY; DIARRHEA; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; HYDROGEN BREATH TEST; INTESTINE TRANSIT TIME; LACTASE DEFICIENCY; LACTOSE INTOLERANCE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ABDOMINAL PAIN; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BETA-GALACTOSIDASE; BREATH TESTS; FEMALE; GASTROINTESTINAL TRANSIT; HUMANS; HYDROGEN; LACTOSE INTOLERANCE; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 54349083840     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2008.02035.x     Document Type: Article

References (69)

1. Gilat T, Russo S, Gelman-Malachi E, Aldor TA. Lactase in man: a nonadaptable enzyme. Gastroenterology 1972 62 : 1125 7.
2. Bodlaj G, Stöcher M, Hufnagl P, Hubmann R, Biesenbach G, Stekel H et al. Genotyping of the lactase-phlorizin hydrolase -13 910 polymorphism by LightCycler PCR and implications for the diagnosis of lactose intolerance. Clin Chem 2006 52 : 148 51.
3. Högenauer C, Hammer HF, Mellitzer K, Renner W, Krejs GJ, Toplak H. Evaluation of a new DNA test compared with the lactose hydrogen breath test for the diagnosis of lactase non-persistence. Eur J Gastroenterol Hepatol 2005 17 : 371 6.
4. Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Järvelä I. Identification of a variant associated with adult-type hypolactasia. Nat Genet 2002 30 : 233 7.
5. Sahi T. Genetics and epidemiology of adult-type hypolactasia. Scand J Gastroenterol Suppl 1994 202 : 7 20.
6. Suarez FL, Savaiano DA, Levitt MD. Review article: the treatment of lactose intolerance. Aliment Pharmacol Ther 1995 9 : 589 97.
7. Gudmand-Hoyer E. The clinical significance of disaccharide maldigestion. Am J Clin Nutr 1994 59 : 735S 41S.
8. Montalto M, Nucera G, Santoro L, Curigliano V, Vastola M, Covino M et al. Effect of exogenous β-galactosidase in patients with lactose malabsorption and intolerance: a crossover double-blind placebo-controlled study. Eur J Clin Nutr 2005 59 : 489 93.
9. Cavalli-Sforza LT, Strata A, Barone A, Cucurachi L. Primary adult lactose malabsorption in Italy: regional differences in prevalence and relationship to lactose intolerance and milk consumption. Am J Clin Nutr 1987 45 : 748 54.
10. Burgio GR, Flatz G, Barbera C, Patane R, Boner A, Cajozzo C et al. Prevalence of primary adult lactose malabsorption and awareness of milk intolerance in Italy. Am J Clin Nutr 1984 39 : 100 4.
11. Di Stefano M, Veneto G, Malservisi S, Strocchi A, Corazza GR. Lactose malabsorption and intolerance in the elderly. Scand J Gastroenterol 2001 36 : 1274 8.
12. Rosado JL, Solomons NW, Lisker R, Bourges H. Enzyme replacement therapy for primary adult lactase deficiency. Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime. Gastroenterology 1984 87 : 1072 82.
13. Metz G, Jenkins DJ, Peters TJ, Newman A, Blendis LM. Breath hydrogen as a diagnostic method for hypolactasia. Lancet 1975 1 : 1155 7.
14. Shaw AD, Davies GJ. Lactose intolerance: problems in diagnosis and treatment. J Clin Gastroenterol 1999 28 : 208 16.
15. Lomer MC, Parkes GC, Sanderson JD. Review article: lactose intolerance in clinical practice - myths and realities. Aliment Pharmacol Ther 2008 27 : 93 103.
16. Obermayer-Pietsch BM, Bonelli CM, Walter DE, Kuhn RJ, Fahrleitner-Pammer A, Berghold A et al. Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. J Bone Miner Res 2004 19 : 42 7.
17. Solomons NW, Guerrero AM, Torun B. Dietary manipulation of postprandial colonic lactose fermentation: II. Addition of exogenous, microbial beta-galactosidases at mealtime. Am J Clin Nutr 1985 41 : 209 21.
18. Matlik L, Savaiano D, McCabe G, VanLoan M, Blue CL, Boushey CJ. Perceived milk intolerance is related to bone mineral content in 10- to 13-year-old female adolescents. Pediatrics 2007 : 120 : e669 77.
19. Strocchi A, Corazza G, Ellis CJ, Gasbarrini G, Levitt MD. Detection of malabsorption of low doses of carbohydrate: accuracy of various breath H2 criteria. Gastroenterology 1993 105 : 1404 10.
20. Beyerlein L, Pohl D, Delco F, Stutz B, Fried M, Tutuian R. Correlation between symptoms developed after the oral ingestion of 50 g lactose and results of hydrogen breath testing for lactose intolerance. Aliment Pharmacol Ther 2008 27 : 659 65.
21. Corazza GR, Benati G, Di SA, Tarozzi C, Strocchi A, Passeri M et al. Lactose intolerance and bone mass in postmenopausal Italian women. Br J Nutr 1995 73 : 479 87.
22. Fernandez-Banares F, Gassull MA. Accuracy of breath H2 criteria to detect carbohydrate malabsorption. Gastroenterology 1994 107 : 323 4.
23. Krawczyk M, Wolska M, Schwartz S, Gruenhage F, Terjung B, Portincasa P et al. Concordance of genetic and breath tests for lactose intolerance in a tertiary referral centre. J Gastrointestin Liver Dis 2008 17 : 135 9.
24. Nilsson TK, Olsson LA. Simultaneous genotyping of the three lactose tolerance-linked polymorphisms LCT -13 907C>G, LCT -13 910C>T and LCT -13 915T>G with Pyrosequencing technology. Clin Chem Lab Med 2008 46 : 80 4.
25. Szilagyi A, Torchinsky A, Calacone A. Possible therapeutic use of loperamide for symptoms of lactose intolerance. Can J Gastroenterol 2000 14 : 581 7.
26. Szilagyi A, Salomon R, Seidman E. Influence of loperamide on lactose handling and oral-caecal transit time. Aliment Pharmacol Ther 1996 10 : 765 70.
27. Onwulata CI, Rao DR, Vankineni P. Relative efficiency of yogurt, sweet acidophilus milk, hydrolyzed-lactose milk, and a commercial lactase tablet in alleviating lactose maldigestion. Am J Clin Nutr 1989 49 : 1233 7.
28. Nielsen OH, Schiotz PO, Rasmussen SN, Krasilnikoff PA. Calcium absorption and acceptance of low-lactose milk among children with primary lactase deficiency. J Pediatr Gastroenterol Nutr 1984 3 : 219 23.
29. Rask PE, Jensen BH, Jensen HJ, Keldsbo IL, Hylander ME, Norby RS. Lactose malabsorption and tolerance of lactose-hydrolyzed milk. A double-blind controlled crossover study. Scand J Gastroenterol 1982 17 : 861 4.
30. Reasoner J, Maculan TP, Rand AG, Thayer WR Jr. Clinical studies with low-lactose milk. Am J Clin Nutr 1981 34 : 54 60.
31. Rasinpera H, Savilahti E, Enattah NS, Kuokkanen M, Totterman N, Lindahl H et al. A genetic test which can be used to diagnose adult-type hypolactasia in children. Gut 2004 53 : 1571 6.
32. Ojetti V, Nucera G, Migneco A, Gabrielli M, Lauritano C, Danese S et al. High prevalence of celiac disease in patients with lactose intolerance. Digestion 2005 71 : 106 10.
33. Pimentel M, Kong Y, Park S. Breath testing to evaluate lactose intolerance in irritable bowel syndrome correlates with lactulose testing and may not reflect true lactose malabsorption. Am J Gastroenterol 2003 98 : 2700 4.
34. Di Stefano M, Missanelli A, Miceli E, Strocchi A, Corazza GR. Hydrogen breath test in the diagnosis of lactose malabsorption: accuracy of new versus conventional criteria. J Lab Clin Med 2004 144 : 313 8.
35. Di Stefano M, Miceli E, Missanelli A, Malservisi S, Strocchi A, Corazza GR. Fermentation of endogenous substrates is responsible for increased fasting breath hydrogen levels in celiac disease. J Lab Clin Med 2004 143 : 163 8.
36. Thompson DG, O'Brien JD, Hardie JM. Influence of the oropharyngeal microflora on the measurement of exhaled breath hydrogen. Gastroenterology 1986 91 : 853 60.
37. Rosenthal A, Solomons NW. Time-course of cigarette smoke contamination of clinical hydrogen breath-analysis tests. Clin Chem 1983 29 : 1980 1.
38. Payne DL, Welsh JD, Claypool PL. Breath hydrogen (H2) response to carbohydrate malabsorption after exercise. J Lab Clin Med 1983 102 : 147 50.
39. Portincasa P, Moschetta A, Baldassarre G, Altomare DF, Palasciano G. Pan-enteric dysmotility, impaired quality of life and alexithymia in a large group of patients meeting the Rome II criteria for irritable bowel. World J Gastroenterol 2003 9 : 2293 9.
40. Portincasa P, Moschetta A, Berardino M, Di Ciaula A, Vacca M, Baldassarre G et al. Impaired gallbladder motility and delayed orocecal transit contribute to pigment gallstone and biliary sludge formation in beta-thalassemia major adults. World J Gastroenterol 2004 10 : 2383 90.
41. Di Ciaula A, Covelli M, Berardino M, Wang DQ, Lapadula G, Palasciano G et al. Gastrointestinal symptoms and motility disorders in patients with systemic scleroderma. BMC Gastroenterol 2008 8 : 7.
42. Pimentel M, Chow EJ, Lin HC. Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol 2000 95 : 3503 6.
43. Newcomer AD, McGill DB, Thomas PJ, Hofmann AF. Prospective comparison of indirect methods for detecting lactase deficiency. N Engl J Med 1975 293 : 1232 6.
44. Tallarida RJ, Murray RB. Manual of Pharmacologic Calculations with Computer Programs. New York : Springer-Verlag 1987.
45. Hintze JL. NCSS, PASS, and GESS. Kaysville, Utah : Number Cruncher Statistical System (NCSS) 2007.
46. Hveem K, Jones KL, Chatterton BE, Horowitz M. Scintigraphic measurement of gastric emptying and ultrasonographic assessment of antral area: relation to appetite. Gut 1996 38 : 816 21.
47. Portincasa P, Altomare DF, Moschetta A, Baldassarre G, Di Ciaula A, Venneman NG et al. The effect of acute oral erythromycin on gallbladder motility and on upper gastrointestinal symptoms in gastrectomized patients with and without gallstones: a randomized, placebo-controlled ultrasonographic study. Am J Gastroenterol 2000 95 : 3444 51.
48. Armitage P, Berry G. Statistical Methods in Medical Research. Oxford : Blackwell Science 1994.
49. Dawson B, Trapp RG. Basic and Clinical Biostatistics. New York : McGraw-Hill 2001.
50. Montalto M, Curigliano V, Santoro L, Vastola M, Cammarota G, Manna R et al. Management and treatment of lactose malabsorption. World J Gastroenterol 2006 12 : 187 91.
51. Corazza GR, Benati G, Sorge M, Strocchi A, Calza G, Gasbarrini G. β-Galactosidase from Aspergillus niger in adult lactose malabsorption: a double-blind crossover study. Aliment Pharmacol Ther 1992 6 : 61 6.
52. Barillas C, Solomons NW. Effective reduction of lactose maldigestion in preschool children by direct addition of β-galactosidases to milk at mealtime. Pediatrics 1987 79 : 766 72.
53. Lami F, Callegari C, Tatali M, Graziano L, Guidetti C, Miglioli M et al. Efficacy of addition of exogenous lactase to milk in adult lactase deficiency. Am J Gastroenterol 1988 83 : 1145 9.
54. Moskovitz M, Curtis C, Gavaler J. Does oral enzyme replacement therapy reverse intestinal lactose malabsorption? Am J Gastroenterol 1987 82 : 632 5.
55. DiPalma JA, Collins MS. Enzyme replacement for lactose malabsorption using a beta-D-galactosidase. J Clin Gastroenterol 1989 11 : 290 3.
56. He T, Priebe MG, Welling GW, Vonk RJ. Effect of lactose on oro-cecal transit in lactose digesters and maldigesters. Eur J Clin Invest 2006 36 : 737 42.
57. Vernia P, Marinaro V, Argnani F, Di Camillo M, Caprilli R. Self-reported milk intolerance in irritable bowel syndrome: what should we believe? Clin Nutr 2004 23 : 996 1000.
58. Vonk RJ, Priebe MG, Koetse HA, Stellaard F, Lenoir-Wijnkoop I, Antoine JM et al. Lactose intolerance: analysis of underlying factors. Eur J Clin Invest 2003 33 : 70 5.
59. Berg A, Eriksson M, Barany F, Einarsson K, Sundgren H, Nylander C et al. Hydrogen concentration in expired air analyzed with a new hydrogen sensor, plasma glucose rise, and symptoms of lactose intolerance after oral administration of 100 gram lactose. Scand J Gastroenterol 1985 20 : 814 22.
60. Cavalli-Sforza LT, Strata A. Double-blind study on the tolerance of four types of milk in lactose malabsorbers and absorbers. Hum Nutr Clin Nutr 1987 41 : 19 30.
61. Suarez FL, Savaiano DA, Levitt MD. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. N Engl J Med 1995 333 : 1 4.
62. Labayen I, Forga L, Gozales A, Lenoir-Wijnkoop I, Nutr R, Martinez JA. Relationship between lactose digestion, gastrointestinal transit time and symptoms in lactose malabsorbers after diary consumption. Aliment Pharmacol Ther 2001 15 : 543 9.
63. Ladas S, Papanikos J, Arapakis G. Lactose malabsorption in Greek adults: correlation of small bowel transit time with the severity of lactose intolerance. Gut 1982 23 : 968 73.
64. Roggero P, Offredi ML, Mosca F, Perazzani M, Mangiaterra V, Ghislanzoni P et al. Lactose absorption and malabsorption in healthy Italian children: do the quantity of malabsorbed sugar and the small bowel transit time play roles in symptom production? J Pediatr Gastroenterol Nutr 1985 4 : 82 6.
65. Lin HC, Elashoff JD, Kwok GM, Gu YG, Meyer JH. Stimulation of duodenal motility by hyperosmolar mannitol depends on local osmoreceptor control. Am J Physiol 1994 266 : G940 G943.
66. Buller HA, RJ. Grand Lactose intolerance. In : WP Creger, CH Coggins, EW Hancock, eds. Annual Review of Medicine: Selected Topics in the Clinical Sciences. Palo Alto, CA : Annual Reviews Inc., 1990, pp. 141 52.
67. He T, Venema K, Priebe MG, Welling GW, Brummer RJ, Vonk RJ. The role of colonic metabolism in lactose intolerance. Eur J Clin Invest 2008.
68. Bond JH, Levitt MD. Quantitative measurement of lactose absorption. Gastroenterology 1976 70 : 1058 62.
69. Terrio K, Auld GW. Osteoporosis knowledge, calcium intake, and weight-bearing physical activity in three age groups of women. J Community Health 2002 27 : 307 20.