In Vitro mechanism-based inactivation of cytochrome P450 3A4 by a new constituent of Cinnamomum burmani

Planta Medica

Volumn 74, Issue 12, 2008, Pages 1474-1480

  Subehan, ^a   Kadota, Shigetoshi ^a   Tezuka, Yasuhiro ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Cinnamomum burmani; CYP3A4; Cytochrome P450 3A4; Lauraceae; Mechanism based inactivation

Indexed keywords

5' HYDROXY 5 HYDROXYMETHYL 4'',5'' METHYLENEDIOXY 1,2,3,4 DIBENZO 1,3,5 CYCLOHEPTATRIENE; CINNAMIC ALDEHYDE CYCLIC SYRINGYL GLYCEROL 1,3 ACETAL; CYTOCHROME P450 3A4; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CINNAMOMUM; CINNAMOMUM BURMANI; DRUG METABOLISM; ENZYME INACTIVATION; ENZYME INHIBITION;

CINNAMOMUM; CYTOCHROME P-450 CYP3A; ENZYME INHIBITORS; HUMANS; KINETICS; MICROSOMES, LIVER; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLANT EXTRACTS;

CINNAMOMUM BURMANNII; LAURACEAE;

EID: 54249151091     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1081351     Document Type: Article

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