Mechanistic-based descriptors for QSAR study of psychotropic drug toxicity

Chemical Biology and Drug Design

Volumn 72, Issue 5, 2008, Pages 409-435

  Esteki, Mahnaz ^a   Khayamian, Taghi ^a  

^a ISFAHAN UNIVERSITY OF TECHNOLOGY   (Iran)

Author keywords

Antidepressants; Anxiolitics; Phenothiazines; Quantitative structure activity relationship

Indexed keywords

ACEPROMAZINE; ACEPROMETAZINE; ALIMEMAZINE; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CHLOROFORM; CHLORPROMAZINE; CHLORPROTHIXENE; CLOZAPINE; DIETHAZINE; FLUPHENAZINE; ISOTHIPENDYL; LEVOMEPROMAZINE; MESORIDAZINE; METHANOLAMINE; METHOPROMAZINE; OXOMEMAZINE; PERAZINE; PERICIAZINE; PERPHENAZINE; PHENOTHIAZINE DERIVATIVE; PHOSGENE; PROMAZINE; PSYCHOTROPIC AGENT; SULFORIDAZINE; THIORIDAZINE; TIOTIXENE; TRICHLORMETHANOL; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACUTE TOXICITY; ARTICLE; CHEMICAL STRUCTURE; DRUG TOXICITY; HYDROGEN BOND; LD 50; MOLECULAR MODEL; OXIDATION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; MICE; MODELS, MOLECULAR; PHENOTHIAZINES; PSYCHOTROPIC DRUGS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 54249133892     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2008.00718.x     Document Type: Article

References (35)

1. Stevens J.L. (2006) Future of toxicology - mechanisms of toxicity and drug safety: where do we go from here?. Chem Res Toxicol 19 : 1393 1401.
2. Langowski J., Long A. (2002) Computer systems for the prediction of xenobiotic metabolism. Adv Drug Deliv Rev 54 : 407 415.
3. Rhodes C., Thomas M., Athis J. (1993) Principles of testing for acute toxic effects. In : Ballantyne B., Marrs T., Turner P., editors. General and Applied Toxicology, Vol. 1. New York : Stockton Press p. 49 87.
4. Walum E. (1998) Acute oral toxicity. Environ Health Perspect 106 : 497 503.
5. Omen G.S. (1995) Assessing the risk assessment paradigm. Toxicology 102 : 23 28.
6. Merlin M.D. (2003) Archaeological evidence for the tradition of psychoactive plant use in the old world. Econ Bot 57 : 295 323.
7. Macherey A.C., Dansette P.M. (2003) Chemical mechanisms of toxicity: basic knowledge for designing safer drugs. In : Wermuth C.G., editor. The Practice of Medicinal Chemistry, Vol. 32. Amsterdam : Elsevier p. 545 560.
8. Guenguerich F.P. (2001) Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem Res Toxicol 14 : 611 650.
9. Mason R.P., Chignell C.F. (1982) Free radicals in pharmacology and toxicology - selected topics. Pharmacol Rev 33 : 189 211.
10. Aust S.D., Chignell C.F., Bray T.M., Kalyanaraman B., Mason R.P. (1993) Free radicals in toxicology. Toxicol Appl Pharmacol 120 : 168 178.
11. Singal P.K., Petkau A., Gerrard J.M., Hrushovetz S., Foerster J. (1988) Free radicals in health and disease. Mol Cell Biochem 84 : 121 122.
12. Anders M.W., Pohl L.R. (1985) Halogenated alkanes. In : Anders M.W., editor. Bioactivation of Foreign Compounds. Orlando, FL : Academic Press Inc. p. 284 315.
13. Benasutti M., Ejadi S., Whitlow M.D., Loechler E.L. (1988) Mapping the binding site of aflatoxin B1 in DNA: systematic analysis of the reactivity of aflatoxin B1 with guanines in different DNA sequences. Biochem 27 : 472 481.
14. Verna L., Whysner J., Williams G.M. (1996) 2-Acetylamino-fluorene mechanistic data and risk assessment: DNA reactivity, enhanced cell proliferation and tumor initiation. Pharmacol Ther 71 : 83 105.
15. Dansette P.M., Thang D.C., Amri H., Mansuy D. (1992) Evidence for thiophene-S-oxide as a primary reactive metabolite of thiovphene in vivo: formation of a dihydrothiophene sulfoxide mercapturic acid. Biochem Biophys Res Commun 186 : 1624 2163.
16. Hypercube, Inc. (1997) Hyperchem 5.0. Gainesville, FL : Hypercube, Inc.
17. Pallant J. (2005) SPSS Survival Manual. A Step by Step Guide to Data Analysis using SPSS. NSW : Allen & Unwin.
18. Martens H., Naes T. (1989) Multivariate Calibration. Chichester : Wiley.
19. Quinones-Torrelo C., Sagrado S., Villanueva-Camanas R.M., Medina-Hernandez M.J. (1999) Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography. J Med Chem 42 : 3154 3162.
20. Budavari S., O'Neill M., Smith A., Heckelman P., Kinneary J. (1996) The Merck Index, 12th edn. Whitehouse Station, NJ : Merck Research Laboratories.
21. Fielding S. (1974) Industrial Pharmacology, Vol. 1: Neuroleptics. New York : Futura.
22. Lindberg U.H., Thorberg S.o., Bengtsson S., Renyi A.L., Ross S.B., Ogren S.O. (1978) Inhibitors of neuronal monoamine uptake. 2. Selective inhibition of 5-hydroxytryptamine uptake by.alpha.-amino acid esters of phenethyl alcohols. J Med Chem 21 : 448.
23. Randall L.O., Baqdon R.E. (1959) Pharmacology of iproniazid and other amine oxidase inhibitors. Ann NY Acad Sci 80 : 626.
24. Malick J.B. (1983) Potentiation of yohimbine-induced lethality in mice: predictor of antidepressant potential. Drug Dev Res 3 : 357.
25. Brown D.F., Kerr H.D. (1994) Sertraline overdose. Ann Pharmacother 28 : 1307.
26. Gyertyán I., Petöcz L., Gacsályi I., Fekete M.I.K., Tekes K., Kápolnai L. (1991) Psychopharmacological effects of an imino-thiazolidine derivative antidepressant candidate, EGYT-4201. Drug Dev Res 22 : 385.
27. Gylys J.A., Muccia P.M.R., Taylor M.K. (1963) Pharmacological and toxicological properties of 2-methyl-3-piperidinopyrazine, a new antidepressant. Ann NY Acad Sci 107 : 899.
28. Squires R.F., Lassen J.B. (1968) Some pharmacological and biochemical properties of v-morpholino-butyrophenone (NSD 2023), a new monoamine oxidase inhibitor. Biochem Pharmacol 17 : 369.
29. Jiho Y. (1982) Drugs in Japan. Tokyo, Japan : Ethical Drugs.
30. 50 values in newborn and adult animals. Toxicol Appl Pharmacol 18 : 185.
31. Bartram T., Coumbarides A. (2008) Toxic levels of tricyclic drugs in accidental overdose. Emerg Med J 25 : 166 167.
32. Garattini S., Mussini E., Randall L.O. editors (1973) The Benzodiazepines. New York : Raven Press.
33. Nakanishi M., Tahara T., Araki K., Shiroki M., Tsumagari T., Takigawa Y. (1973) Psychotropic drugs. 18. Synthesis and structure-activity relations of 5-phenyl-1,3-dihydro-2H-thieno[2,3-e][1,4]diazepin-2-ones. J Med Chem 16 : 214.
34. Gordon M. (1973) Psychopharmacological Agents, Vol. 3. Syracuse, NY : Academic Press.
35. Chidress S.J. (1970) Antianxiety agents, 3rd edn. In : Burger A., editor. Medicinal Chemistry (Part II). New York : Wiley-Interscience p. 1498 1510.