메뉴 건너뛰기




Volumn 35, Issue 11, 2008, Pages 1388-1394

Neuroprotective effects of a selective N-methyl-D-aspartate NR2b receptor antagonist in the 6-hydroxydopamine rat model of Parkinson's disease

Author keywords

Animal model; Neuroprotection; NR2B N methyl D aspartate (NMDA) receptor; Parkinson's disease; Substantia nigra

Indexed keywords

4 TRIFLUOROMETHOXY N (2 TRIFLUOROMETHYLBENZYL)BENZAMIDINE; BZAD 01; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; OXIDOPAMINE; UNCLASSIFIED DRUG;

EID: 54249111876     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.05046.x     Document Type: Conference Paper
Times cited : (19)

References (29)
  • 1
    • 2542431131 scopus 로고    scopus 로고
    • Rationale for and use of NMDA receptor antagonists in Parkinson's disease
    • Hallett PJ, Standaert DG. Rationale for and use of NMDA receptor antagonists in Parkinson's disease. Pharmacol. Ther. 2004 102 : 155 74.
    • (2004) Pharmacol. Ther. , vol.102 , pp. 155-74
    • Hallett, P.J.1    Standaert, D.G.2
  • 2
    • 10544247317 scopus 로고    scopus 로고
    • Early institution of bromocriptine in Parkinson's disease inhibits the emergence of levodopa-associated motor side effects. Long-term results of the PRADO study
    • Przuntek H, Welzel D, Gerlach M et al. Early institution of bromocriptine in Parkinson's disease inhibits the emergence of levodopa-associated motor side effects. Long-term results of the PRADO study. J. Neural Transm. 1996 103 : 699 715.
    • (1996) J. Neural Transm. , vol.103 , pp. 699-715
    • Przuntek, H.1    Welzel, D.2    Gerlach, M.3
  • 3
    • 0141449053 scopus 로고    scopus 로고
    • Sensorimotor deficits in a unilateral intrastriatal 6-OHDA partial lesion model of Parkinson's disease in marmoset monkeys
    • Eslamboli A, Baker HF, Ridley RM, Annett LE. Sensorimotor deficits in a unilateral intrastriatal 6-OHDA partial lesion model of Parkinson's disease in marmoset monkeys. Exp. Neurol. 2003 183 : 418 29.
    • (2003) Exp. Neurol. , vol.183 , pp. 418-29
    • Eslamboli, A.1    Baker, H.F.2    Ridley, R.M.3    Annett, L.E.4
  • 4
    • 0034852744 scopus 로고    scopus 로고
    • Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies
    • Palmer GC. Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies. Curr. Drug Targets 2001 2 : 241 71.
    • (2001) Curr. Drug Targets , vol.2 , pp. 241-71
    • Palmer, G.C.1
  • 5
    • 0031975509 scopus 로고    scopus 로고
    • The role of NMDA receptors in the slow neuronal degeneration of Parkinson's disease
    • Loopuijt LD, Schmidt WJ. The role of NMDA receptors in the slow neuronal degeneration of Parkinson's disease. Amino Acids 1998 14 : 17 23.
    • (1998) Amino Acids , vol.14 , pp. 17-23
    • Loopuijt, L.D.1    Schmidt, W.J.2
  • 6
    • 0037216407 scopus 로고    scopus 로고
    • The N-methyl-d-aspartate receptor subunit NR2B: Localization, functional properties, regulation, and clinical implications
    • Loftis JM, Janowsky A. The N-methyl-d-aspartate receptor subunit NR2B: Localization, functional properties, regulation, and clinical implications. Pharmacol. Ther. 2003 97 : 55 85.
    • (2003) Pharmacol. Ther. , vol.97 , pp. 55-85
    • Loftis, J.M.1    Janowsky, A.2
  • 7
    • 0346218258 scopus 로고    scopus 로고
    • Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease
    • Calon F, Rajput AH, Hornykiewicz O, Bedard PJ, Di Paolo T. Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease. Neurobiol. Dis. 2003 14 : 404 16.
    • (2003) Neurobiol. Dis. , vol.14 , pp. 404-16
    • Calon, F.1    Rajput, A.H.2    Hornykiewicz, O.3    Bedard, P.J.4    Di Paolo, T.5
  • 8
    • 0141458065 scopus 로고    scopus 로고
    • The role of N-methyl-d-aspartate (NMDA) receptors in pain: A review
    • Petrenko AB, Yamakura T, Baba H, Shimoji K. The role of N-methyl-d-aspartate (NMDA) receptors in pain: A review. Anesth. Analg. 2003 97 : 1108 16.
    • (2003) Anesth. Analg. , vol.97 , pp. 1108-16
    • Petrenko, A.B.1    Yamakura, T.2    Baba, H.3    Shimoji, K.4
  • 9
    • 0036391844 scopus 로고    scopus 로고
    • Glutamatergic mechanisms in different disease states: Overview and therapeutical implications. An introduction
    • Tzschentke TM. Glutamatergic mechanisms in different disease states: Overview and therapeutical implications. An introduction. Amino Acids 2002 23 : 147 52.
    • (2002) Amino Acids , vol.23 , pp. 147-52
    • Tzschentke, T.M.1
  • 10
    • 1842664189 scopus 로고    scopus 로고
    • Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease
    • Loschmann PA, De Groote C, Smith L et al. Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease. Exp. Neurol. 2004 187 : 86 93.
    • (2004) Exp. Neurol. , vol.187 , pp. 86-93
    • Loschmann, P.A.1    De Groote, C.2    Smith, L.3
  • 11
    • 0036589832 scopus 로고    scopus 로고
    • Characterisation of striatal NMDA receptors involved in the generation of parkinsonian symptoms: Intrastriatal microinjection studies in the 6-OHDA-lesioned rat
    • Nash JE, Brotchie JM. Characterisation of striatal NMDA receptors involved in the generation of parkinsonian symptoms: Intrastriatal microinjection studies in the 6-OHDA-lesioned rat. Mov. Disord. 2002 17 : 455 66.
    • (2002) Mov. Disord. , vol.17 , pp. 455-66
    • Nash, J.E.1    Brotchie, J.M.2
  • 12
    • 0032914455 scopus 로고    scopus 로고
    • Antagonists selective for NMDA receptors containing the NR2B subunit
    • Chenard BL, Menniti FS. Antagonists selective for NMDA receptors containing the NR2B subunit. Curr. Pharmaceut. Des. 1999 5 : 381 404.
    • (1999) Curr. Pharmaceut. Des. , vol.5 , pp. 381-404
    • Chenard, B.L.1    Menniti, F.S.2
  • 13
    • 3042833166 scopus 로고    scopus 로고
    • The NR2B-selective NMDA receptor antagonist CP-101 606 exacerbates l-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of l-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease
    • Nash JE, Ravenscroft P, McGuire S, Crossman AR, Menniti FS, Brotchie JM. The NR2B-selective NMDA receptor antagonist CP-101 606 exacerbates l-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of l-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease. Exp. Neurol. 2004 188 : 471 9.
    • (2004) Exp. Neurol. , vol.188 , pp. 471-9
    • Nash, J.E.1    Ravenscroft, P.2    McGuire, S.3    Crossman, A.R.4    Menniti, F.S.5    Brotchie, J.M.6
  • 15
    • 0030272769 scopus 로고    scopus 로고
    • The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments
    • Schwarting RK, Huston JP. The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments. Prog. Neurobiol. 1996 50 : 275 331.
    • (1996) Prog. Neurobiol. , vol.50 , pp. 275-331
    • Schwarting, R.K.1    Huston, J.P.2
  • 17
    • 33244457440 scopus 로고    scopus 로고
    • Developing a preclinical model of Parkinson's disease: A study of behaviour in rats with graded 6-OHDA lesions
    • Truong L, Allbutt H, Kassiou M, Henderson JM. Developing a preclinical model of Parkinson's disease: A study of behaviour in rats with graded 6-OHDA lesions. Behav. Brain Res. 2006 169 : 1 9.
    • (2006) Behav. Brain Res. , vol.169 , pp. 1-9
    • Truong, L.1    Allbutt, H.2    Kassiou, M.3    Henderson, J.M.4
  • 18
    • 33845430429 scopus 로고    scopus 로고
    • Use of the narrow beam test in the rat, 6-hydroxydopamine model of Parkinson's disease
    • Allbutt HN, Henderson JM. Use of the narrow beam test in the rat, 6-hydroxydopamine model of Parkinson's disease. J. Neurosci. Meth. 2007 159 : 195 202.
    • (2007) J. Neurosci. Meth. , vol.159 , pp. 195-202
    • Allbutt, H.N.1    Henderson, J.M.2
  • 19
    • 0037450073 scopus 로고    scopus 로고
    • Relationships between various behavioural abnormalities and nigrostriatal dopamine depletion in the unilateral 6-OHDA-lesioned rat
    • Henderson JM, Watson S, Halliday GM, Heinemann T, Gerlach M. Relationships between various behavioural abnormalities and nigrostriatal dopamine depletion in the unilateral 6-OHDA-lesioned rat. Behav. Brain Res. 2003 139 : 105 13.
    • (2003) Behav. Brain Res. , vol.139 , pp. 105-13
    • Henderson, J.M.1    Watson, S.2    Halliday, G.M.3    Heinemann, T.4    Gerlach, M.5
  • 20
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: Substantia nigra regional selectivity
    • Fearnley JML, Lees AJ. Ageing and Parkinson's disease: Substantia nigra regional selectivity. Brain 1991 114 : 2283 301.
    • (1991) Brain , vol.114 , pp. 2283-301
    • Fearnley, J.M.L.1    Lees, A.J.2
  • 21
    • 0025818117 scopus 로고
    • Partial lesion of the substantia nigra: Relation between extent of lesion and rotational behavior
    • Carman LS, Gage FH, Shults CW. Partial lesion of the substantia nigra: Relation between extent of lesion and rotational behavior. Brain Res. 1991 553 : 275 83.
    • (1991) Brain Res. , vol.553 , pp. 275-83
    • Carman, L.S.1    Gage, F.H.2    Shults, C.W.3
  • 22
    • 0037208608 scopus 로고    scopus 로고
    • Functional neuroanatomy of the basal ganglia in Parkinson's disease
    • Wichmann T, DeLong MR. Functional neuroanatomy of the basal ganglia in Parkinson's disease. Adv. Neurol. 2003 91 : 9 18.
    • (2003) Adv. Neurol. , vol.91 , pp. 9-18
    • Wichmann, T.1    Delong, M.R.2
  • 24
    • 0033918014 scopus 로고    scopus 로고
    • Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson's disease: Clinical and therapeutic implications
    • Henderson JM, Carpenter K, Cartwright H, Halliday GM. Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson's disease: Clinical and therapeutic implications. Brain 2000 123 : 1410 21.
    • (2000) Brain , vol.123 , pp. 1410-21
    • Henderson, J.M.1    Carpenter, K.2    Cartwright, H.3    Halliday, G.M.4
  • 25
    • 0033710030 scopus 로고    scopus 로고
    • Molecular effects of dopamine on striatal-projection pathways
    • Gerfen CR. Molecular effects of dopamine on striatal-projection pathways. Trends Neurosci. 2000 23 (Suppl S64 70.
    • (2000) Trends Neurosci. , vol.23
    • Gerfen, C.R.1
  • 26
    • 0035074475 scopus 로고    scopus 로고
    • Subthalamic infusion of an NMDA antagonist prevents basal ganglia metabolic changes and nigral degeneration in a rodent model of Parkinson's disease
    • Blandini F, Nappi G, Greenamyre JT. Subthalamic infusion of an NMDA antagonist prevents basal ganglia metabolic changes and nigral degeneration in a rodent model of Parkinson's disease. Ann. Neurol. 2001 49 : 525 9.
    • (2001) Ann. Neurol. , vol.49 , pp. 525-9
    • Blandini, F.1    Nappi, G.2    Greenamyre, J.T.3
  • 27
    • 0029897501 scopus 로고    scopus 로고
    • Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: Behavioural and immunohistochemical studies
    • Piallat B, Benazzouz A, Benabid AL. Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: Behavioural and immunohistochemical studies. Eur. J. Neurosci. 1996 8 : 1408 14.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 1408-14
    • Piallat, B.1    Benazzouz, A.2    Benabid, A.L.3
  • 28
    • 28244493418 scopus 로고    scopus 로고
    • Functional NR2B- and NR2D-containing NMDA receptor channels in rat substantia nigra dopaminergic neurones
    • Jones S, Gibb AJ. Functional NR2B- and NR2D-containing NMDA receptor channels in rat substantia nigra dopaminergic neurones. J. Physiol. 2005 569 : 209 21.
    • (2005) J. Physiol. , vol.569 , pp. 209-21
    • Jones, S.1    Gibb, A.J.2
  • 29
    • 0004521596 scopus 로고    scopus 로고
    • Enhanced tyrosine phosphorylation of striatal NMDA receptor subunits: Effect of dopaminergic denervation and l-DOPA administration
    • Oh JD, Russell DS, Vaughan CL, Chase TN. Enhanced tyrosine phosphorylation of striatal NMDA receptor subunits: Effect of dopaminergic denervation and l-DOPA administration. Brain Res. 1998 820 : 150 9.
    • (1998) Brain Res. , vol.820 , pp. 150-9
    • Oh, J.D.1    Russell, D.S.2    Vaughan, C.L.3    Chase, T.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.