Mucin gene expression in human laryngeal epithelia: Effect of laryngopharyngeal reflux

Annals of Otology, Rhinology and Laryngology

Volumn 117, Issue 9, 2008, Pages 688-695

  Samuels, Tina L ^a   Handler, Ethan ^a   Syring, Michael L ^a   Pajewski, Nicholas M ^a   Blumin, Joel H ^a   Kerschner, Joseph E ^a   Johnston, Nikki ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Laryngopharyngeal reflux; Mucin; Pepsin; Reflux

Indexed keywords

MESSENGER RNA; MUCIN; MUCIN 1; MUCIN 13; MUCIN 15; MUCIN 16; MUCIN 17; MUCIN 18; MUCIN 19; MUCIN 2; MUCIN 20; MUCIN 3; MUCIN 4; MUCIN 5; MUCIN 6; MUCIN 7; MUCIN 8; MUCIN 9; PEPSIN A; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CASE REPORT; COMPARATIVE STUDY; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LARYNGEAL BIOPSY; LARYNGITIS; LARYNGOPHARYNGEAL REFLUX; LARYNX INJURY; LARYNX MUCOSA; MALE; MUCIN GENE; PH MEASUREMENT; PHYSICAL DISEASE BY BODY FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RATING SCALE; REFLUX FINDING SCORE; REFLUX SYMPTOM INDEX; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

EID: 54249092323     PISSN: 00034894     EISSN: None     Source Type: Journal    
DOI: 10.1177/000348940811700911     Document Type: Article

References (30)

1. Ali MS, Pearson JP. Upper airway mucin gene expression: a review. Laryngoscope 2007;117:932-8.
2. Hollingsworth MA, Swanson BJ. Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer 2004;4:45-60.
3. Morrison MD. Is chronic gastroesophageal reflux a causative factor in glottic carcinoma? Otolaryngol Head Neck Surg 1988;99:370-3.
4. Ward PH, Hanson DG. Reflux as an etiological factor of carcinoma of the laryngopharynx. Laryngoscope 1988;98:1195-9.
5. Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991;101(suppl 53):1-78.
6. Bortolotti M. Laryngospasm and reflex central apnoea caused by aspiration of refluxed gastric content in adults. Gut 1989;30:233-8.
7. Cherry J, Margulies SI. Contact ulcer of the larynx. Laryngoscope 1968;78:1937-40.
8. Delahunty JE. Acid laryngitis. J Laryngol Otol 1972;86:335-42.
9. Koufman JA, Amin MR, Panetti M. Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngol Head Neck Surg 2000;123:385-8.
10. Koufman JA, Aviv JE, Casiano RR, Shaw GY. Laryngopharyngeal reflux: position statement of the committee on speech, voice, and swallowing disorders of the American Academy of Otolaryngology-Head and Neck Surgery. Otolaryngol Head Neck Surg 2002;127:32-5.
11. Orlando RC. Pathogenesis of gastroesophageal reflux disease. Am J Med Sci 2003;326:274-8.
12. Lipan MJ, Reidenberg JS, Laitman JT. Anatomy of reflux: a growing health problem affecting structures of the head and neck. Anat Rec B New Anat 2006;289:261-70.
13. Kinoshita M, Kume E, Igarashi S, Saito N, Narita H. Role of salivary mucin in the protection of rat esophageal mucosa from acid and pepsin-induced injury. Am J Physiol 1999;277:G796-G800.
14. Burjonrappa SC, Reddimasu S, Nawaz Z, Gao X, Sharma P, Loggie B. Mucin expression profile in Barrett's, dysplasia, adenocarcinoma sequence in the esophagus. Indian J Cancer 2007;44:1-5.
15. Namiot Z, Sarosiek J, Marcinkiewicz M, Edmunds MC, McCallum RW. Declined human esophageal mucin secretion in patients with severe reflux esophagitis. Dig Dis Sci 1994;39:2523-9.
16. Yuan JS, Reed A, Chen F, Stewart CN Jr. Statistical analysis of real-time PCR data. BMC Bioinformatics 2006;7:85.
17. Fu WJ, Hu J, Spencer T, Carroll R, Wu G. Statistical models in assessing fold change of gene expression in real-time RT-PCR experiments. Comput Biol Chem 2006;30:21-6.
18. Kerschner JE. Mucin gene expression in human middle ear epithelium. Laryngoscope 2007;117:1666-76.
19. Moehle C, Ackermann N, Langmann T, et al. Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J Mol Med 2006;84:1055-66.
20. Takeuchi K, Yagawa M, Ishinaga H, Kishioka C, Harada T, Majima Y. Mucin gene expression in the effusions of otitis media with effusion. Int J Pediatr Otorhinolaryngol 2003;67:53-8.
21. Liévin-Le Moal V, Huet G, Aubert JP, et al. Activation of mucin exocytosis and upregulation of MUC genes in polarized human intestinal mucin-secreting cells by the thiol-activated exotoxin listeriolysin O. Cell Microbiol 2002;4:515-29.
22. Voynow JA, Gendler SJ, Rose MC. Regulation of mucin genes in chronic inflammatory airway diseases. Am J Respir Cell Mol Biol 2006;34:661-5.
23. Jeannon JP, Stafford FW, Soames JV, Wilson JA. Altered MUC1 and MUC2 glycoprotein expression in laryngeal cancer. Otolaryngol Head Neck Surg 2001;124:199-202.
24. Croce MV, Price MR, Segal-Eiras A. Detection and isolation of MUC1 mucin from larynx squamous cell carcinoma. Pathol Oncol Res 2000;6:93-9.
25. Paleri V, Pearson JP, Bulmer D, Jeannon JP, Wight RG, Wilson JA. Expression of mucin gene products in laryngeal squamous cancer. Otolaryngol Head Neck Surg 2004;131:84-8.
26. Ho SB, Dvorak LA, Moor RE, et al. Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing. Gastroenterology 2006;131:1501-17.
27. Ylitalo R, Baugh A, Li W, Thibeault S. Effect of acid and pepsin on gene expression in laryngeal fibroblasts. Ann Otol Rhinol Laryngol 2004;113:866-71.
28. Johnston N, Dettmar PW, Lively MO, et al. Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease. Ann Otol Rhinol Laryngol 2006;115:47-58.
29. Mainie I, Tutuian R, Shay S, et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut 2006;55:1398-402.
30. Johnston N, Dettmar PW, Bishwokarma B, Lively MO, Koufman JA. Activity/stability of human pepsin: implications for reflux attributed laryngeal disease. Laryngoscope 2007;117:1036-9.