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Volumn 23, Issue 11, 2008, Pages 3446-3455

FK778 ameliorates post-transplant expression of fibrogenic growth factors and development of chronic rejection changes in rat kidney allografts

Author keywords

Acute rejection; Chronic allograft nephropathy; FK778; PDGF; TGF

Indexed keywords

2 CYANO 3 HYDROXY N [4 (TRIFLUOROMETHYL)PHENYL] 6 HEPTYNAMIDE; CYCLOSPORIN A; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

EID: 54149098616     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn340     Document Type: Article
Times cited : (8)

References (21)
  • 1
    • 0034667904 scopus 로고    scopus 로고
    • Increased impact of acute rejection on chronic allograft failure in recent era
    • Meier-Kriesche HU, Ojo AO, Hanson JA et al. Increased impact of acute rejection on chronic allograft failure in recent era. Transplantation 2000; 70: 1098-1100
    • (2000) Transplantation , vol.70 , pp. 1098-1100
    • Meier-Kriesche, H.U.1    Ojo, A.O.2    Hanson, J.A.3
  • 2
    • 24944462903 scopus 로고    scopus 로고
    • Chronic renal allograft rejection: Pathophysiologic considerations
    • Joosten SA, Sijpkens YW, van Kooten C et al. Chronic renal allograft rejection: pathophysiologic considerations. Kidney Int 2005; 68: 1-13
    • (2005) Kidney Int , vol.68 , pp. 1-13
    • Joosten, S.A.1    Sijpkens, Y.W.2    van Kooten, C.3
  • 3
    • 0027326797 scopus 로고
    • International standardization of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplant pathology
    • Solez K, Axelsen RA, Benediktsson H et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int 1993; 44: 411-422
    • (1993) Kidney Int , vol.44 , pp. 411-422
    • Solez, K.1    Axelsen, R.A.2    Benediktsson, H.3
  • 5
    • 0037378011 scopus 로고    scopus 로고
    • The impact of repeated subclinical acute rejection on the progression of chronic allograft nephropathy
    • Shishido S, Asanuma H, Nakai H et al. The impact of repeated subclinical acute rejection on the progression of chronic allograft nephropathy. J Am Soc Nephrol 2003; 14: 1046-1052
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1046-1052
    • Shishido, S.1    Asanuma, H.2    Nakai, H.3
  • 6
    • 12344314265 scopus 로고    scopus 로고
    • Fitzsimmons WE, First MR: FK778, a synthetic malononitrilamide. Yonsei Med J 2004; 45: 1132-1135
    • Fitzsimmons WE, First MR: FK778, a synthetic malononitrilamide. Yonsei Med J 2004; 45: 1132-1135
  • 7
    • 3142734960 scopus 로고    scopus 로고
    • The effects of FK778 in combination with tacrolimus and steroids: A phase II multicenter study in renal transplant patients
    • Vanrenterghem Y, van Hooff JP, Klinger M et al. The effects of FK778 in combination with tacrolimus and steroids: a phase II multicenter study in renal transplant patients. Transplantation 2004; 78: 9-14
    • (2004) Transplantation , vol.78 , pp. 9-14
    • Vanrenterghem, Y.1    van Hooff, J.P.2    Klinger, M.3
  • 8
    • 0025980747 scopus 로고
    • Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection
    • Bartlett RR, Dimitrijevic M, Mattar T et al. Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection. Agents Actions 1991; 32: 10-21
    • (1991) Agents Actions , vol.32 , pp. 10-21
    • Bartlett, R.R.1    Dimitrijevic, M.2    Mattar, T.3
  • 9
    • 0030811256 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide
    • Shawver LK, Schwartz DP, Mann E et al. Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide. Clin Cancer Res 1997; 3: 1167-1177
    • (1997) Clin Cancer Res , vol.3 , pp. 1167-1177
    • Shawver, L.K.1    Schwartz, D.P.2    Mann, E.3
  • 10
    • 0032845287 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor activity of a novel immunomodulatory drug, leflunomide: Mechanisms of action
    • Xu X, Shen J, Mall JW et al. In vitro and in vivo antitumor activity of a novel immunomodulatory drug, leflunomide: mechanisms of action. Biochem Pharmacol 1999; 58: 1405-1413
    • (1999) Biochem Pharmacol , vol.58 , pp. 1405-1413
    • Xu, X.1    Shen, J.2    Mall, J.W.3
  • 11
    • 0042467489 scopus 로고    scopus 로고
    • Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: Potential applications for restenosis and chronic rejection
    • discussion 471-453
    • Savikko J, Von Willebrand E, Hayry P. Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection. Transplantation 2003; 76: 455-458; discussion 471-453
    • (2003) Transplantation , vol.76 , pp. 455-458
    • Savikko, J.1    Von Willebrand, E.2    Hayry, P.3
  • 12
    • 3142668958 scopus 로고    scopus 로고
    • FK778 attenuates lymphocyteendothelium interaction after cardiac transplantation: In vivo and in vitro studies
    • Deuse T, Schrepfer S, Schafer H et al. FK778 attenuates lymphocyteendothelium interaction after cardiac transplantation: in vivo and in vitro studies. Transplantation 2004; 78: 71-77
    • (2004) Transplantation , vol.78 , pp. 71-77
    • Deuse, T.1    Schrepfer, S.2    Schafer, H.3
  • 13
    • 18144376604 scopus 로고    scopus 로고
    • FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival
    • Schrepfer S, Deuse T, Schafer H et al. FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival. Transpl Int 2005; 18: 215-220
    • (2005) Transpl Int , vol.18 , pp. 215-220
    • Schrepfer, S.1    Deuse, T.2    Schafer, H.3
  • 14
    • 34147139494 scopus 로고    scopus 로고
    • The effect of FK778 on the progression of chronic allograft nephropathy in a ratmodel
    • Lutz J, Huang H, Deng M et al. The effect of FK778 on the progression of chronic allograft nephropathy in a ratmodel. Transplantation 2007; 83: 741-746
    • (2007) Transplantation , vol.83 , pp. 741-746
    • Lutz, J.1    Huang, H.2    Deng, M.3
  • 15
    • 0035879236 scopus 로고    scopus 로고
    • Early induction of platelet-derived growth factor ligands and receptors in acute rat renal allograft rejection
    • Savikko J, Kallio EA, von Willebrand E. Early induction of platelet-derived growth factor ligands and receptors in acute rat renal allograft rejection. Transplantation 2001; 72: 31-37
    • (2001) Transplantation , vol.72 , pp. 31-37
    • Savikko, J.1    Kallio, E.A.2    von Willebrand, E.3
  • 16
    • 33847761900 scopus 로고    scopus 로고
    • Banff '05 Meeting Report: Differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN')
    • Solez K, Colvin RB, Racusen LC et al. Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 2007; 7: 518-526
    • (2007) Am J Transplant , vol.7 , pp. 518-526
    • Solez, K.1    Colvin, R.B.2    Racusen, L.C.3
  • 17
    • 0021949297 scopus 로고
    • Thrombocyte aggregates in renal allografts. Analysis with fine-needle aspiration biopsy and monoclonal antithrombocyte antibodies
    • von Willebrand E, Zola H, Hayry P. Thrombocyte aggregates in renal allografts. Analysis with fine-needle aspiration biopsy and monoclonal antithrombocyte antibodies. Transplantation 1985; 39: 258-262
    • (1985) Transplantation , vol.39 , pp. 258-262
    • von Willebrand, E.1    Zola, H.2    Hayry, P.3
  • 18
    • 0032910625 scopus 로고    scopus 로고
    • The Banff 97 working classification of renal allograft pathology
    • Racusen LC, Solez K, Colvin RB et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713-723
    • (1999) Kidney Int , vol.55 , pp. 713-723
    • Racusen, L.C.1    Solez, K.2    Colvin, R.B.3
  • 19
    • 0026632933 scopus 로고
    • Induction of HLA class II antigen and interleukin 2 receptor expression in acute vascular rejection of human kidney allografts
    • von Willebrand E, Salmela K, Isoniemi H et al. Induction of HLA class II antigen and interleukin 2 receptor expression in acute vascular rejection of human kidney allografts. Transplantation 1992; 53: 1077-1081
    • (1992) Transplantation , vol.53 , pp. 1077-1081
    • von Willebrand, E.1    Salmela, K.2    Isoniemi, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.