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Volumn 14, Issue 8, 2008, Pages 683-689

The oral mucosa as a therapeutic target for xerostomia

Author keywords

Absorption; Buccal mucosa; Dry mouth; ENaC; Epithelial sodium channel; Xerostomia

Indexed keywords

AMILORIDE; CEVIMELINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; PILOCARPINE; POTASSIUM; PS 55202; PS 5522; SALIVA SUBSTITUTE; SODIUM; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

EID: 54049146937     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/j.1601-0825.2008.01486.x     Document Type: Review
Times cited : (31)

References (52)
  • 1
    • 0014378259 scopus 로고
    • [The experimental study on the permeability of the oral mucosa with sodium-24 solution]
    • Aoyama W (1968). [The experimental study on the permeability of the oral mucosa with sodium-24 solution]. Shigaku 56 : 555 578.
    • (1968) Shigaku , vol.56 , pp. 555-578
    • Aoyama, W.1
  • 2
    • 0027572233 scopus 로고
    • Sjogren's syndrome: Oral and dental considerations
    • 78-82, 84-86.
    • Atkinson JC, Fox PC (1993). Sjogren's syndrome: oral and dental considerations. J Am Dent Assoc 124 : 74 76, 78-82, 84-86.
    • (1993) J Am Dent Assoc , vol.124 , pp. 74-76
    • Atkinson, J.C.1    Fox, P.C.2
  • 3
    • 84964151695 scopus 로고
    • Human Saliva. XIII. Rate of flow of resting saliva of healthy individuals
    • Becks H, Wainwright WW (1943). Human Saliva. XIII. Rate of flow of resting saliva of healthy individuals. J Dent Res 22 : 391 396.
    • (1943) J Dent Res , vol.22 , pp. 391-396
    • Becks, H.1    Wainwright, W.W.2
  • 4
    • 0021495251 scopus 로고
    • Whole-saliva secretion rates in old and young healthy subjects
    • Ben-Aryeh H, Miron D, Szargel R, Gutman D (1984). Whole-saliva secretion rates in old and young healthy subjects. J Dent Res 63 : 1147 1148.
    • (1984) J Dent Res , vol.63 , pp. 1147-1148
    • Ben-Aryeh, H.1    Miron, D.2    Szargel, R.3    Gutman, D.4
  • 5
    • 0022337995 scopus 로고
    • Xerostomia in the elderly: Prevalence, diagnosis, complications and treatment
    • Ben-Aryeh H, Miron D, Berdicevsky I, Szargel R, Gutman D (1985). Xerostomia in the elderly: prevalence, diagnosis, complications and treatment. Gerodontology 4 : 77 82.
    • (1985) Gerodontology , vol.4 , pp. 77-82
    • Ben-Aryeh, H.1    Miron, D.2    Berdicevsky, I.3    Szargel, R.4    Gutman, D.5
  • 6
    • 34047166052 scopus 로고    scopus 로고
    • Airway surface dehydration in cystic fibrosis: Pathogenesis and therapy
    • Boucher RC (2007). Airway surface dehydration in cystic fibrosis: pathogenesis and therapy. Annu Rev Med 58 : 157 170.
    • (2007) Annu Rev Med , vol.58 , pp. 157-170
    • Boucher, R.C.1
  • 8
    • 0023388554 scopus 로고
    • The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oral mucosa
    • Collins LM, Dawes C (1987). The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oral mucosa. J Dent Res 66 : 1300 1302.
    • (1987) J Dent Res , vol.66 , pp. 1300-1302
    • Collins, L.M.1    Dawes, C.2
  • 9
    • 0023287175 scopus 로고
    • Physiological factors affecting salivary flow rate, oral sugar clearance, and the sensation of dry mouth in man
    • Dawes C (1987). Physiological factors affecting salivary flow rate, oral sugar clearance, and the sensation of dry mouth in man. J Dent Res 66 : 648 653.
    • (1987) J Dent Res , vol.66 , pp. 648-653
    • Dawes, C.1
  • 10
    • 2642582252 scopus 로고    scopus 로고
    • How much saliva is enough for avoidance of xerostomia?
    • Dawes C (2004). How much saliva is enough for avoidance of xerostomia? Caries Res 38 : 236 240.
    • (2004) Caries Res , vol.38 , pp. 236-240
    • Dawes, C.1
  • 11
    • 4043098253 scopus 로고    scopus 로고
    • Salivary status in patients treated for head and neck cancer
    • Dawes C, Odlum O (2004). Salivary status in patients treated for head and neck cancer. J Can Dent Assoc 70 : 397 400.
    • (2004) J Can Dent Assoc , vol.70 , pp. 397-400
    • Dawes, C.1    Odlum, O.2
  • 12
    • 0030186159 scopus 로고    scopus 로고
    • Measurement and comparison of the residual saliva on various oral mucosal and dentition surfaces in humans
    • DiSabato-Mordarski T, Kleinberg I (1996a). Measurement and comparison of the residual saliva on various oral mucosal and dentition surfaces in humans. Arch Oral Biol 41 : 655 665.
    • (1996) Arch Oral Biol , vol.41 , pp. 655-665
    • Disabato-Mordarski, T.1    Kleinberg, I.2
  • 13
    • 0030210438 scopus 로고    scopus 로고
    • Use of a paper-strip absorption method to measure the depth and volume of saliva retained in embrasures and occlusal fussae of the human dentition
    • DiSabato-Mordarski T, Kleinberg I (1996b). Use of a paper-strip absorption method to measure the depth and volume of saliva retained in embrasures and occlusal fussae of the human dentition. Arch Oral Biol 41 : 809 820.
    • (1996) Arch Oral Biol , vol.41 , pp. 809-820
    • Disabato-Mordarski, T.1    Kleinberg, I.2
  • 14
    • 10744219607 scopus 로고    scopus 로고
    • Expression of aquaporin isoforms during human and mouse tooth development
    • Felszeghy S, Modis L, Nemeth P et al (2004). Expression of aquaporin isoforms during human and mouse tooth development. Arch Oral Biol 49 : 247 257.
    • (2004) Arch Oral Biol , vol.49 , pp. 247-257
    • Felszeghy, S.1    Modis, L.2    Nemeth, P.3    Al, E.4
  • 15
    • 2642560997 scopus 로고    scopus 로고
    • Salivary enhancement therapies
    • Fox PC (2004). Salivary enhancement therapies. Caries Res 38 : 241 246.
    • (2004) Caries Res , vol.38 , pp. 241-246
    • Fox, P.C.1
  • 16
    • 0025736885 scopus 로고
    • Pilocarpine treatment of salivary gland hypofunction and dry mouth (xerostomia)
    • Fox PC, Atkinson JC, Macynski AA et al (1991). Pilocarpine treatment of salivary gland hypofunction and dry mouth (xerostomia). Arch Intern Med 151 : 1149 1152.
    • (1991) Arch Intern Med , vol.151 , pp. 1149-1152
    • Fox, P.C.1    Atkinson, J.C.2    MacYnski, A.A.3    Al, E.4
  • 17
    • 0024379582 scopus 로고
    • Hyposalivatory drug use, whole stimulated salivary flow, and mouth dryness in older, long-term care residents
    • Handelman SL, Baric JM, Saunders RH, Espeland MA (1989). Hyposalivatory drug use, whole stimulated salivary flow, and mouth dryness in older, long-term care residents. Spec Care Dentist 9 : 12 18.
    • (1989) Spec Care Dentist , vol.9 , pp. 12-18
    • Handelman, S.L.1    Baric, J.M.2    Saunders, R.H.3    Espeland, M.A.4
  • 18
    • 0034102514 scopus 로고    scopus 로고
    • The effect of sodium lauryl sulphate, triclosan and zinc on the permeability of normal oral mucosa
    • Healy CM, Cruchley AT, Thornhill MH, Williams DM (2000). The effect of sodium lauryl sulphate, triclosan and zinc on the permeability of normal oral mucosa. Oral Dis 6 : 118 123.
    • (2000) Oral Dis , vol.6 , pp. 118-123
    • Healy, C.M.1    Cruchley, A.T.2    Thornhill, M.H.3    Williams, D.M.4
  • 19
    • 0020983675 scopus 로고
    • Secretion rate and buffer effect of resting and stimulated whole saliva as a function of age and sex
    • Heintze U, Birkhed D, Bjorn H (1983). Secretion rate and buffer effect of resting and stimulated whole saliva as a function of age and sex. Swed Dent J 7 : 227 238.
    • (1983) Swed Dent J , vol.7 , pp. 227-238
    • Heintze, U.1    Birkhed, D.2    Bjorn, H.3
  • 20
    • 41149164824 scopus 로고    scopus 로고
    • Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl) -N'-4-[4-(2,3-dihydroxypropoxy) phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease
    • Hirsh AJ, Zhang J, Zamurs A et al (2008). Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy) phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease. J Pharmacol Exp Ther 325 : 77 88.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 77-88
    • Hirsh, A.J.1    Zhang, J.2    Zamurs, A.3    Al, E.4
  • 21
    • 0034214249 scopus 로고    scopus 로고
    • Post-radiation severe xerostomia relieved by pilocarpine: A prospective French cooperative study
    • Horiot JC, Lipinski F, Schraub S et al (2000). Post-radiation severe xerostomia relieved by pilocarpine: a prospective French cooperative study. Radiother Oncol 55 : 233 239.
    • (2000) Radiother Oncol , vol.55 , pp. 233-239
    • Horiot, J.C.1    Lipinski, F.2    Schraub, S.3    Al, E.4
  • 22
    • 0027497089 scopus 로고
    • The structural barrier of absorptive mucosae: Site difference of the permeability of fluorescein isothiocyanate-labelled dextran in rabbits
    • Hosoya K, Kubo H, Natsume H, Sugibayashi K, Morimoto Y, Yamashita S (1993). The structural barrier of absorptive mucosae: site difference of the permeability of fluorescein isothiocyanate-labelled dextran in rabbits. Biopharm Drug Dispos 14 : 685 695.
    • (1993) Biopharm Drug Dispos , vol.14 , pp. 685-695
    • Hosoya, K.1    Kubo, H.2    Natsume, H.3    Sugibayashi, K.4    Morimoto, Y.5    Yamashita, S.6
  • 24
    • 0027185013 scopus 로고
    • Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer
    • Johnson JT, Ferretti GA, Nethery WJ et al (1993). Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer. N Engl J Med 329 : 390 395.
    • (1993) N Engl J Med , vol.329 , pp. 390-395
    • Johnson, J.T.1    Ferretti, G.A.2    Nethery, W.J.3    Al, E.4
  • 25
    • 0016143547 scopus 로고
    • The permeability and barrier functions of the oral mucosa with respect to water and electrolytes. Studies of the transport of water, sodium and potassium through the human mucosal surface in vivo
    • Kaaber S (1974). The permeability and barrier functions of the oral mucosa with respect to water and electrolytes. Studies of the transport of water, sodium and potassium through the human mucosal surface in vivo. Acta Odontol Scand Suppl 32 : 3 47.
    • (1974) Acta Odontol Scand Suppl , vol.32 , pp. 3-47
    • Kaaber, S.1
  • 26
    • 54049144871 scopus 로고
    • Studies on the permeability of the oral mucosa. I. Permeability of inorganicions
    • Kawamura Y, Takata M (1960). Studies on the permeability of the oral mucosa. I. Permeability of inorganicions. J Dent Res 39 : 517 524.
    • (1960) J Dent Res , vol.39 , pp. 517-524
    • Kawamura, Y.1    Takata, M.2
  • 27
    • 0021433191 scopus 로고
    • The volume of saliva in the mouth before and after swallowing
    • Lagerlof F, Dawes C (1984). The volume of saliva in the mouth before and after swallowing. J Dent Res 63 : 618 621.
    • (1984) J Dent Res , vol.63 , pp. 618-621
    • Lagerlof, F.1    Dawes, C.2
  • 28
    • 46049111418 scopus 로고    scopus 로고
    • The Food and Drug Administration approves lubiprostone for irritable Bowel syndrome with constipation
    • Lang L (2008). The Food and Drug Administration approves lubiprostone for irritable Bowel syndrome with constipation. Gastroenterology 135 : 7.
    • (2008) Gastroenterology , vol.135 , pp. 7
    • Lang, L.1
  • 30
    • 0027273213 scopus 로고
    • A multicenter, randomized, double-blind, placebo-controlled, dose-titration study of oral pilocarpine for treatment of radiation-induced xerostomia in head and neck cancer patients
    • LeVeque FG, Montgomery M, Potter D et al (1993). A multicenter, randomized, double-blind, placebo-controlled, dose-titration study of oral pilocarpine for treatment of radiation-induced xerostomia in head and neck cancer patients. J Clin Oncol 11 : 1124 1131.
    • (1993) J Clin Oncol , vol.11 , pp. 1124-1131
    • Leveque, F.G.1    Montgomery, M.2    Potter, D.3    Al, E.4
  • 31
    • 0020985240 scopus 로고
    • Recent advances in oral mucosal research
    • Mackenzie IC, Binnie WH (1983). Recent advances in oral mucosal research. J Oral Pathol 12 : 389 415.
    • (1983) J Oral Pathol , vol.12 , pp. 389-415
    • MacKenzie, I.C.1    Binnie, W.H.2
  • 32
    • 2442718786 scopus 로고    scopus 로고
    • Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
    • Mall M, Grubb BR, Harkema JR, O'Neal WK, Boucher RC (2004). Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice. Nat Med 10 : 487 493.
    • (2004) Nat Med , vol.10 , pp. 487-493
    • Mall, M.1    Grubb, B.R.2    Harkema, J.R.3    O'Neal, W.K.4    Boucher, R.C.5
  • 33
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    • Matsui H, Grubb BR, Tarran R et al (1998). Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95 : 1005 1015.
    • (1998) Cell , vol.95 , pp. 1005-1015
    • Matsui, H.1    Grubb, B.R.2    Tarran, R.3    Al, E.4
  • 34
    • 0032868691 scopus 로고    scopus 로고
    • Water channel protein AQP3 is present in epithelia exposed to the environment of possible water loss
    • Matsuzaki T, Suzuki T, Koyama H, Tanaka S, Takata K (1999). Water channel protein AQP3 is present in epithelia exposed to the environment of possible water loss. J Histochem Cytochem 47 : 1275 1286.
    • (1999) J Histochem Cytochem , vol.47 , pp. 1275-1286
    • Matsuzaki, T.1    Suzuki, T.2    Koyama, H.3    Tanaka, S.4    Takata, K.5
  • 36
    • 84989558265 scopus 로고
    • Longitudinal study of stimulated whole saliva in an elderly population
    • Osterberg T, Birkhed D, Johansson C, Svanborg A (1992). Longitudinal study of stimulated whole saliva in an elderly population. Scand J Dent Res 100 : 340 345.
    • (1992) Scand J Dent Res , vol.100 , pp. 340-345
    • Osterberg, T.1    Birkhed, D.2    Johansson, C.3    Svanborg, A.4
  • 37
    • 0036185150 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled study of cevimeline in Sjogren's syndrome patients with xerostomia and keratoconjunctivitis sicca
    • Petrone D, Condemi JJ, Fife R, Gluck O, Cohen S, Dalgin P (2002). A double-blind, randomized, placebo-controlled study of cevimeline in Sjogren's syndrome patients with xerostomia and keratoconjunctivitis sicca. Arthritis Rheum 46 : 748 754.
    • (2002) Arthritis Rheum , vol.46 , pp. 748-754
    • Petrone, D.1    Condemi, J.J.2    Fife, R.3    Gluck, O.4    Cohen, S.5    Dalgin, P.6
  • 38
    • 0023445893 scopus 로고
    • A quantitative study of histological changes in the human parotid gland occurring with adult age
    • Scott J, Flower EA, Burns J (1987). A quantitative study of histological changes in the human parotid gland occurring with adult age. J Oral Pathol 16 : 505 510.
    • (1987) J Oral Pathol , vol.16 , pp. 505-510
    • Scott, J.1    Flower, E.A.2    Burns, J.3
  • 39
    • 0035407825 scopus 로고    scopus 로고
    • Permeability barrier properties of oral keratinocyte cultures: A model of intact human oral mucosa
    • Selvaratnam L, Cruchley AT, Navsaria H et al (2001). Permeability barrier properties of oral keratinocyte cultures: a model of intact human oral mucosa. Oral Dis 7 : 252 258.
    • (2001) Oral Dis , vol.7 , pp. 252-258
    • Selvaratnam, L.1    Cruchley, A.T.2    Navsaria, H.3    Al, E.4
  • 40
    • 0026127279 scopus 로고
    • How much saliva is enough? 'Normal' function defined
    • Ship JA, Fox PC, Baum BJ (1991). How much saliva is enough? 'Normal' function defined. J Am Dent Assoc 122 : 63 69.
    • (1991) J Am Dent Assoc , vol.122 , pp. 63-69
    • Ship, J.A.1    Fox, P.C.2    Baum, B.J.3
  • 43
    • 54049155522 scopus 로고    scopus 로고
    • Use of sodium channel blocker to relieve dryness in Sjögren's (Abstract No. 0553)
    • Singh ML, Papas AS, Fox PC et al (2008). Use of sodium channel blocker to relieve dryness in Sjögren's (Abstract No. 0553). J Dent Res 87 (Special Issue A 101150.
    • (2008) J Dent Res , vol.87 , Issue.101-150
    • Singh, M.L.1    Papas, A.S.2    Fox, P.C.3    Al, E.4
  • 44
    • 0023284203 scopus 로고
    • Overview of Sjogren's syndrome
    • Talal N (1987). Overview of Sjogren's syndrome. J Dent Res 66 (Special No. 672 674.
    • (1987) J Dent Res , vol.66 , pp. 672-674
    • Talal, N.1
  • 45
    • 0034885663 scopus 로고    scopus 로고
    • The CF salt controversy: In vivo observations and therapeutic approaches
    • Tarran R, Grubb BR, Parsons D et al (2001). The CF salt controversy: in vivo observations and therapeutic approaches. Mol Cell 8 : 149 158.
    • (2001) Mol Cell , vol.8 , pp. 149-158
    • Tarran, R.1    Grubb, B.R.2    Parsons, D.3    Al, E.4
  • 46
    • 34250887562 scopus 로고    scopus 로고
    • Rationale for hypertonic saline therapy for cystic fibrosis lung disease
    • Tarran R, Donaldson S, Boucher RC (2007). Rationale for hypertonic saline therapy for cystic fibrosis lung disease. Semin Respir Crit Care Med 28 : 295 302.
    • (2007) Semin Respir Crit Care Med , vol.28 , pp. 295-302
    • Tarran, R.1    Donaldson, S.2    Boucher, R.C.3
  • 47
    • 7444243225 scopus 로고    scopus 로고
    • Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye
    • Tauber J, Davitt WF, Bokosky JE et al (2004). Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye. Cornea 23 : 784 792.
    • (2004) Cornea , vol.23 , pp. 784-792
    • Tauber, J.1    Davitt, W.F.2    Bokosky, J.E.3    Al, E.4
  • 48
    • 34248354789 scopus 로고    scopus 로고
    • The epithelium as a target for therapy in cystic fibrosis
    • Thelin WR, Boucher RC (2007). The epithelium as a target for therapy in cystic fibrosis. Curr Opin Pharmacol 7 : 290 295.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 290-295
    • Thelin, W.R.1    Boucher, R.C.2
  • 49
    • 34748884549 scopus 로고    scopus 로고
    • Dry mouth and its effects on the oral health of elderly people
    • Turner MD, Ship JA (2007). Dry mouth and its effects on the oral health of elderly people. J Am Dent Assoc 138 (Suppl. 15S 20S.
    • (2007) J Am Dent Assoc , vol.138
    • Turner, M.D.1    Ship, J.A.2
  • 50
    • 0033601774 scopus 로고    scopus 로고
    • Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjogren syndrome: A randomized, placebo-controlled, fixed-dose, multicenter trial. P92-01 Study Group
    • Vivino FB, Al-Hashimi I, Khan Z et al (1999). Pilocarpine tablets for the treatment of dry mouth and dry eye symptoms in patients with Sjogren syndrome: a randomized, placebo-controlled, fixed-dose, multicenter trial. P92-01 Study Group. Arch Intern Med 159 : 174 181.
    • (1999) Arch Intern Med , vol.159 , pp. 174-181
    • Vivino, F.B.1    Al-Hashimi, I.2    Khan, Z.3    Al, E.4
  • 51
    • 0032102814 scopus 로고    scopus 로고
    • Oral mucosal wetness in hypo- and normosalivators
    • Wolff M, Kleinberg I (1998). Oral mucosal wetness in hypo- and normosalivators. Arch Oral Biol 43 : 455 462.
    • (1998) Arch Oral Biol , vol.43 , pp. 455-462
    • Wolff, M.1    Kleinberg, I.2
  • 52
    • 0033082254 scopus 로고    scopus 로고
    • The effect of ammonium glycopyrrolate (Robinul)-induced xerostomia on oral mucosal wetness and flow of gingival crevicular fluid in humans
    • Wolff MS, Kleinberg I (1999). The effect of ammonium glycopyrrolate (Robinul)-induced xerostomia on oral mucosal wetness and flow of gingival crevicular fluid in humans. Arch Oral Biol 44 : 97 102.
    • (1999) Arch Oral Biol , vol.44 , pp. 97-102
    • Wolff, M.S.1    Kleinberg, I.2


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