메뉴 건너뛰기




Volumn 1239, Issue , 2008, Pages 207-215

The mode of death of epilepsy-induced "dark" neurons is neither necrosis nor apoptosis: An electron-microscopic study

Author keywords

4 aminopyridine; Brain cortex; Electron microscopy; Rat; Silver staining

Indexed keywords

4 AMINOPYRIDINE;

EID: 54049142822     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.08.069     Document Type: Article
Times cited : (32)

References (33)
  • 1
    • 0020661170 scopus 로고
    • Pathogenesis of brain lesions caused by experimental epilepsy. Light and electron-microscopic changes in the rat hippocampus following bicucculine-induced status epilepticus
    • Attilio A., Söderfeldt B., Kalimo H., Olsson Y., and Siesjö B.K. Pathogenesis of brain lesions caused by experimental epilepsy. Light and electron-microscopic changes in the rat hippocampus following bicucculine-induced status epilepticus. Acta Neuropathol. 59 (1983) 11-24
    • (1983) Acta Neuropathol. , vol.59 , pp. 11-24
    • Attilio, A.1    Söderfeldt, B.2    Kalimo, H.3    Olsson, Y.4    Siesjö, B.K.5
  • 2
    • 0024204729 scopus 로고
    • Biological differences between ischemia, hypoglycemia and epilepsy
    • Auer R.N., and Siesjö B.K. Biological differences between ischemia, hypoglycemia and epilepsy. Ann. Neurol. 24 (1988) 699-707
    • (1988) Ann. Neurol. , vol.24 , pp. 699-707
    • Auer, R.N.1    Siesjö, B.K.2
  • 3
    • 0022263019 scopus 로고
    • The temporal evolution of hypoglycemic brain damage. I. Light- and electron-microscopic findings in the rat cerebral cortex
    • Auer R.N., Kalimo H., Olsson Y., and Siesjö B.K. The temporal evolution of hypoglycemic brain damage. I. Light- and electron-microscopic findings in the rat cerebral cortex. Acta Neuropathol. 67 (1985) 13-24
    • (1985) Acta Neuropathol. , vol.67 , pp. 13-24
    • Auer, R.N.1    Kalimo, H.2    Olsson, Y.3    Siesjö, B.K.4
  • 4
    • 0002647395 scopus 로고    scopus 로고
    • Hypoxia and related conditions
    • Love S., Louis D.N., and Ellison D.W. (Eds), Arnold, London
    • Auer R.N., Dunn J.F., and Sutherland G.R. Hypoxia and related conditions. In: Love S., Louis D.N., and Ellison D.W. (Eds). Greenfield's Neuropathology (2008), Arnold, London 63-105
    • (2008) Greenfield's Neuropathology , pp. 63-105
    • Auer, R.N.1    Dunn, J.F.2    Sutherland, G.R.3
  • 5
    • 54049126237 scopus 로고    scopus 로고
    • Baracskay, P., Szepesy, Z.S., Orbán, G., Juhász, G., Czurkó, A., in press. Gneralization of seizures parallels the formation of "dark" neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat. Brain Res.
    • Baracskay, P., Szepesy, Z.S., Orbán, G., Juhász, G., Czurkó, A., in press. Gneralization of seizures parallels the formation of "dark" neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat. Brain Res.
  • 6
    • 0001251845 scopus 로고
    • The post mortem origin and mechanism of neuronal hyperchromatosis and nuclear pycnosis
    • Cammermeyer J. The post mortem origin and mechanism of neuronal hyperchromatosis and nuclear pycnosis. Exp. Neurol. 2 (1960) 399-405
    • (1960) Exp. Neurol. , vol.2 , pp. 399-405
    • Cammermeyer, J.1
  • 7
    • 0036190852 scopus 로고    scopus 로고
    • Glycogen-rich and glycogen-depleted astrocytes in the oedematous human cerebral cortex associated with brain trauma, tumours and congenital malformations: an electron microscopy study
    • Castejon O.J., Diaz M., Castejon H.V., and Castellano A. Glycogen-rich and glycogen-depleted astrocytes in the oedematous human cerebral cortex associated with brain trauma, tumours and congenital malformations: an electron microscopy study. Brain Inj. 16 (2002) 109-132
    • (2002) Brain Inj. , vol.16 , pp. 109-132
    • Castejon, O.J.1    Diaz, M.2    Castejon, H.V.3    Castellano, A.4
  • 8
    • 0033982064 scopus 로고    scopus 로고
    • Temporal profile of neuronal injury following pilocarpine or kainic acid-induced status epilepticus
    • Covolan L., and Mello L.E. Temporal profile of neuronal injury following pilocarpine or kainic acid-induced status epilepticus. Epilepsy Res. 39 (2000) 133-152
    • (2000) Epilepsy Res. , vol.39 , pp. 133-152
    • Covolan, L.1    Mello, L.E.2
  • 9
    • 0038082233 scopus 로고    scopus 로고
    • Recovery versus death of "dark" (compacted) neurons in non-impaired parenchymal environment
    • Csordás A., Mázló M., and Gallyas F. Recovery versus death of "dark" (compacted) neurons in non-impaired parenchymal environment. Acta Neuropathol. 106 (2003) 37-49
    • (2003) Acta Neuropathol. , vol.106 , pp. 37-49
    • Csordás, A.1    Mázló, M.2    Gallyas, F.3
  • 10
    • 34547397897 scopus 로고    scopus 로고
    • Novel cell-biological ideas deducible from morphological observations on "dark" neurons revisited
    • Gallyas F. Novel cell-biological ideas deducible from morphological observations on "dark" neurons revisited. Ideggyogy. Szle. 60 (2007) 212-222
    • (2007) Ideggyogy. Szle. , vol.60 , pp. 212-222
    • Gallyas, F.1
  • 11
    • 0025337139 scopus 로고
    • Golgi-like domonstration of "dark" neurons with an argyrophil III method for experimental neuropathology
    • Gallyas F., Güldner F.H., Zoltay G., and Wolff J.R. Golgi-like domonstration of "dark" neurons with an argyrophil III method for experimental neuropathology. Acta Neuropathol. 79 (1990) 620-628
    • (1990) Acta Neuropathol. , vol.79 , pp. 620-628
    • Gallyas, F.1    Güldner, F.H.2    Zoltay, G.3    Wolff, J.R.4
  • 12
    • 0027141379 scopus 로고
    • Four modified silver methods for thick sections of formaldehyde-fixed mammalian central nervous tissue: "dark" neurons, perikarya of all neurons, microglial cells and capillaries
    • Gallyas F., Hsu M., and Buzsáki G. Four modified silver methods for thick sections of formaldehyde-fixed mammalian central nervous tissue: "dark" neurons, perikarya of all neurons, microglial cells and capillaries. J. Neurosci. Methods 50 (1993) 159-164
    • (1993) J. Neurosci. Methods , vol.50 , pp. 159-164
    • Gallyas, F.1    Hsu, M.2    Buzsáki, G.3
  • 13
    • 0036943357 scopus 로고    scopus 로고
    • Traumatic compaction of the axonal cytoskeleton indiuces argyrophilia: histological and theoretical importance
    • Gallyas F., Farkas O., and Mázló M. Traumatic compaction of the axonal cytoskeleton indiuces argyrophilia: histological and theoretical importance. Acta Neuropathol. 103 (2002) 36-42
    • (2002) Acta Neuropathol. , vol.103 , pp. 36-42
    • Gallyas, F.1    Farkas, O.2    Mázló, M.3
  • 14
    • 2442539085 scopus 로고    scopus 로고
    • Gel-to-gel phase transition may occur in mammalian cells: mechanism of formation of "dark" (compacted) neurons
    • Gallyas F., Farkas O., and Mázló M. Gel-to-gel phase transition may occur in mammalian cells: mechanism of formation of "dark" (compacted) neurons. Biol. Cell 96 (2004) 313-324
    • (2004) Biol. Cell , vol.96 , pp. 313-324
    • Gallyas, F.1    Farkas, O.2    Mázló, M.3
  • 15
    • 12944322239 scopus 로고    scopus 로고
    • "Dark" (compacted) neurons may not die through the necrotic pathway
    • Gallyas F., Csordás A., Schwarcz A., and Mázló M. "Dark" (compacted) neurons may not die through the necrotic pathway. Exp. Brain Res. 160 (2005) 473-486
    • (2005) Exp. Brain Res. , vol.160 , pp. 473-486
    • Gallyas, F.1    Csordás, A.2    Schwarcz, A.3    Mázló, M.4
  • 16
    • 33748440200 scopus 로고    scopus 로고
    • Pathological circumstances impair the ability of "dark" neurons to undergo spontaneous recovery
    • Gallyas F., Gasz B., Sziget A., and Mázló M. Pathological circumstances impair the ability of "dark" neurons to undergo spontaneous recovery. Brain Res. 1110 (2006) 211-220
    • (2006) Brain Res. , vol.1110 , pp. 211-220
    • Gallyas, F.1    Gasz, B.2    Sziget, A.3    Mázló, M.4
  • 17
    • 0036019165 scopus 로고    scopus 로고
    • Mechanism of cell death in neurodegenerative diseases: fashion, fiction and facts
    • Graeber M.B., and Moran L.B. Mechanism of cell death in neurodegenerative diseases: fashion, fiction and facts. Brain Pathol. 12 (2002) 385-390
    • (2002) Brain Pathol. , vol.12 , pp. 385-390
    • Graeber, M.B.1    Moran, L.B.2
  • 18
    • 1042306482 scopus 로고    scopus 로고
    • Cellular pathology of the central nervous system
    • Graham D.I., and Lantos P.L. (Eds), Arnold, London
    • Graeber M.B., Blakemore W.F., and Kreutzberg G.W. Cellular pathology of the central nervous system. In: Graham D.I., and Lantos P.L. (Eds). Greenfield's Neuropathology (2002), Arnold, London 123-191
    • (2002) Greenfield's Neuropathology , pp. 123-191
    • Graeber, M.B.1    Blakemore, W.F.2    Kreutzberg, G.W.3
  • 19
    • 0023521813 scopus 로고
    • An ultrastructural study of spontaneous cell death in mouse mastocytoma with particular reference to dark cells
    • Harmon B.V. An ultrastructural study of spontaneous cell death in mouse mastocytoma with particular reference to dark cells. J. Pathol. 153 (1987) 345-355
    • (1987) J. Pathol. , vol.153 , pp. 345-355
    • Harmon, B.V.1
  • 20
    • 0023902887 scopus 로고
    • The nature and timing of excitotoxic neuronal injury in the cerebral cortex, hippocampus, thalamus due to flurothyl-induced status epilepticus
    • Ingvar M., Morgan P.F., and Auer R.N. The nature and timing of excitotoxic neuronal injury in the cerebral cortex, hippocampus, thalamus due to flurothyl-induced status epilepticus. Acta Neuropathol. 75 (1988) 362-369
    • (1988) Acta Neuropathol. , vol.75 , pp. 362-369
    • Ingvar, M.1    Morgan, P.F.2    Auer, R.N.3
  • 21
    • 0002204915 scopus 로고
    • Definition and incidence of apoptosis: an historical perspective
    • Tomel L.D., and Cope F.O. (Eds), Cold Spring Harbor Laboratory Press
    • Kerr J.F.R., and Harmon B.V. Definition and incidence of apoptosis: an historical perspective. In: Tomel L.D., and Cope F.O. (Eds). Apoptosis, the Molecular Basis of Cell Death (1991), Cold Spring Harbor Laboratory Press 5-29
    • (1991) Apoptosis, the Molecular Basis of Cell Death , pp. 5-29
    • Kerr, J.F.R.1    Harmon, B.V.2
  • 22
    • 32944480749 scopus 로고    scopus 로고
    • Electrically induced gel-to-gel phase-transition in neurons
    • Kellermayer R., Zsombok A., Auer T., and Gallyas F. Electrically induced gel-to-gel phase-transition in neurons. Cell Biol. Intern. 30 (2006) 175-182
    • (2006) Cell Biol. Intern. , vol.30 , pp. 175-182
    • Kellermayer, R.1    Zsombok, A.2    Auer, T.3    Gallyas, F.4
  • 23
    • 34547969966 scopus 로고    scopus 로고
    • Morphological effects of transcardially perfused SDS on the rat brain
    • Kovács B., Bukovics P., and Gallyas F. Morphological effects of transcardially perfused SDS on the rat brain. Biol. Cell 99 (2007) 425-432
    • (2007) Biol. Cell , vol.99 , pp. 425-432
    • Kovács, B.1    Bukovics, P.2    Gallyas, F.3
  • 24
    • 34247103522 scopus 로고    scopus 로고
    • The fate of "dark" neurons induced by transient focal cerebral ischemia in a non-necrotic and non-excitotoxic environment: neurobiological aspects
    • Kövesdi E., Pál J., and Gallyas F. The fate of "dark" neurons induced by transient focal cerebral ischemia in a non-necrotic and non-excitotoxic environment: neurobiological aspects. Brain Res. 1147 (2007) 472-483
    • (2007) Brain Res. , vol.1147 , pp. 472-483
    • Kövesdi, E.1    Pál, J.2    Gallyas, F.3
  • 25
    • 0037307212 scopus 로고    scopus 로고
    • To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways
    • Liou A.K., Clark L.S., Henshall D.C., Yin X.M., and Chen J. To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways. Prog. Neurobiol. 69 (2003) 103-142
    • (2003) Prog. Neurobiol. , vol.69 , pp. 103-142
    • Liou, A.K.1    Clark, L.S.2    Henshall, D.C.3    Yin, X.M.4    Chen, J.5
  • 26
    • 0031718713 scopus 로고    scopus 로고
    • Silver development in microscopy and bioanalysis: past and present. Review article
    • Newman G.R., and Jasani A.B. Silver development in microscopy and bioanalysis: past and present. Review article. J. Pathol. 186 (1998) 119-125
    • (1998) J. Pathol. , vol.186 , pp. 119-125
    • Newman, G.R.1    Jasani, A.B.2
  • 27
    • 0034669136 scopus 로고    scopus 로고
    • Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and ion channels
    • Pena F., and Tapia R. Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and ion channels. Neuroscience 101 (2000) 547-561
    • (2000) Neuroscience , vol.101 , pp. 547-561
    • Pena, F.1    Tapia, R.2
  • 28
    • 0021225723 scopus 로고
    • The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia
    • Smith M.L., Auer R.N., and Siesjö B.K. The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropathol. 64 (1984) 319-332
    • (1984) Acta Neuropathol. , vol.64 , pp. 319-332
    • Smith, M.L.1    Auer, R.N.2    Siesjö, B.K.3
  • 29
    • 0021053647 scopus 로고
    • Bicucculine-induced epileptic brain injury. Transient and persistent cell changes in rat cerebral cortex in the early recovery period
    • Söderfeldt B., Kalimo H., Olsson Y., and Siesjö B.K. Bicucculine-induced epileptic brain injury. Transient and persistent cell changes in rat cerebral cortex in the early recovery period. Acta Neuropathol. 62 (1983) 87-95
    • (1983) Acta Neuropathol. , vol.62 , pp. 87-95
    • Söderfeldt, B.1    Kalimo, H.2    Olsson, Y.3    Siesjö, B.K.4
  • 30
    • 77953060553 scopus 로고    scopus 로고
    • Love S., Louis D.N., and Ellison D.W. (Eds), Arnold, London
    • Thom M., Sisodiya S., and Najm I. Neuropathology of epilepsy. In: Love S., Louis D.N., and Ellison D.W. (Eds) (2008), Arnold, London 833-877
    • (2008) Neuropathology of epilepsy , pp. 833-877
    • Thom, M.1    Sisodiya, S.2    Najm, I.3
  • 31
    • 0023491915 scopus 로고
    • Apoptosis: cell death in tissue relations
    • Wyllie A.H. Apoptosis: cell death in tissue relations. J. Pathol. 153 (1987) 313-316
    • (1987) J. Pathol. , vol.153 , pp. 313-316
    • Wyllie, A.H.1
  • 32
  • 33
    • 12344279991 scopus 로고    scopus 로고
    • Basophilia, acidophilia and argyrophilia of "dark" (compacted) neurons in the course of their formation, recovery or death in an otherwise undamaged environment
    • Zsombok A., Tóth Z.S., and Gallyas F. Basophilia, acidophilia and argyrophilia of "dark" (compacted) neurons in the course of their formation, recovery or death in an otherwise undamaged environment. J. Neurosci. Methods 142 (2005) 145-152
    • (2005) J. Neurosci. Methods , vol.142 , pp. 145-152
    • Zsombok, A.1    Tóth, Z.S.2    Gallyas, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.