Discovery of a phosphatidylserine-recognizing peptide and its utility in molecular imaging of tumour apoptosis

Journal of Cellular and Molecular Medicine

Volumn 12, Issue 5A, 2008, Pages 1649-1660

  Thapa, Narendra ^a   Kim, Soyoun ^a   So, In Sup ^a   Lee, Byung Heon ^a   Kwon, Ick Chan ^b   Choi, Kuiwon ^b   Kim, In San ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

Annexin V; Apoptosis; Peptide; Phage display; Phosphatidylserine

Indexed keywords

PEPTIDE; PHOSPHATIDYLSERINE;

AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; ARTICLE; BACTERIOPHAGE M13; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; GENETICS; MALE; METABOLISM; MOUSE; NEOPLASM; NUCLEIC ACID DATABASE; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BACTERIOPHAGE M13; CELL LINE, TUMOR; DATABASES, NUCLEIC ACID; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS; PEPTIDES; PHOSPHATIDYLSERINES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA; MUS MUSCULUS;

EID: 54049124091     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00305.x     Document Type: Article

References (29)

1. Yamaji-Hasegawa A, Tsujimoto M. Asymmetric distribution of phospholipids in biomembranes. Biol Pharm Bull. 2006 29 : 1547 53.
2. Zwaal RF, Comfurius P, Bevers EM. Surface exposure of phosphatidylserine in pathological cells. Cell Mol Life Sci. 2005 62 : 971 88.
3. Dasgupta SK, Guchhait P, Thiagarajan P. Lactoadherin binding and phosphatidylserine expression on cell surface-comparison with annexin A5. Transl Res. 2006 148 : 19 25.
4. Ran S, He J, Huang X, Soares M, Scothorn D, Thorpe PE. Antitumor effects of a monoclonal antibody that binds anion-ic phospholipids on the surface of tumor blood vessels in mice. Clin Cancer Res. 2005 11 : 1551 62.
5. Ran S, Downes A, Thorpe PE. Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res. 2000 62 : 6132 40.
6. Corsten MF, Hofstra L, Narula J, Reutelingsperger C P. Counting heads in the war against cancer: defining the role of annexin A5 imaging in cancer. Cancer Res. 2006 66 : 1255 60.
7. Zhao M, Zhu X, Ji S, Zhou J, Ozker KS, Fang W, Molthen RC, Hellman RS. 99mTc -labeled C2A domain of synaptotagmin I as a target-specific molecular probe for noninvansive imaging of acute myocardial infarction. J Nucl Med. 2006 47 : 1367 74.
8. Lampl Y, Lorberboym M, Blankenberg FG, Sadeh M, Gilad R. Annexin V SPECT imaging of phosphatidylserine expression in patients with dementia. Neurobiology. 2006 66 : 1253 64.
9. Ran S, Downes A, Thorpe PE. Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res. 2002 62 : 6132 40.
10. Kuriyama S, Taguchi Y, Nishimura K, Mizuguchi K, Kobayashi K, Katayama Y, Yanagibashi K, Niidome T. Peptide vector for gene delivery with high affinity for phosphatidylserine. J Pept Sci. 2006 12 : 626 32.
11. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis, flow cytometry detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled annexin V. J Immunol Methods. 1995 184 : 39 51.
12. DiVittorio KM, Johnson JR, Johansson E, Reynolds AJ, Jolliffe KA, Smith BD. Synthetic peptides with selective affinity for apoptotic cells. Org Biomol Chem. 2006 4 : 1966 76.
13. Laakko T, King L, Fraker P. Versatility of merocyanine 540 for the flow cytometric detection of apoptosis in human and murine cells. J Immunol Methods. 2002 261 : 129 39.
14. Hanshaw RG, Lakshmi C, Lambert TN, Johnson JR, Smith BD. Fluorescent detection of apoptotic cells by using zinc coordination complexes with a selective affinity for membrane surfaces enriched with phosphatidylserine. Chem Bio Chem. 2005 6 : 2214 20.
15. Bose S, Tuunainen I, Parry M, Medina OP, Mancini G, Kinnunen PK. Binding of cationic liposomes to apoptotic cells. Analy Biochem. 2004 331 : 385 94.
16. Quinti L, Weissleder R, Tung C-H. A fluorescent nanosensor for apoptotic cells. Nano Let. 2006 6 : 488 90.
17. Laumonier C, Segers J, Laurent S, Michel A, Coppee F, Belayew A, Elst LV, Muller R. A new peptidic vector for molecular imaging of apoptosis, identified by phage display technology. J Biomol Screening. 2006 11 : 537 45.
18. Shi J, Shi Y, Waehrens LN, Rasmussen JT, Heegard CW, Gilbert GE. Lactadherin detects early phosphatidylserine exposure on immobilized leukemia cells undergoing programmed cell death. Cytometry Part A. 2007 69A : 1193 201.
19. Jung HI, Kettunen MI, Davletov B, Brindle KM. Detection of apoptosis using the C2A domain of synaptotagmin I. Bioconjug Chem. 2004 15 : 983 7.
20. Signore A, Annovazzi A, Chianelli M, Corsetti F, van de Wiele C, Watherhouse RN. Peptide radiopharmaceuticals for diagnosis and therapy. Eur J Nucl Med. 2001 28 : 1555 65.
21. Kimura T. Human opioid peptide metenkephalin binds to anionic phosphatidylserine in high preference to zwitterionic phosphatidylchoine: natural-abundance 13C NMR study on the binding state in large unilamellar vesicles. Biochemistry. 2006 45 : 15601 9.
22. Nakai Y, Nomura Y, Sato T, Shiratsuchi A, Nakanishi Y. Isolation of a Drosophila gene coding for a protein containing a novel phosphatidylserine- binding motif. J Biochem. 2005 137 : 593 9.
23. Corsten MF, Hofstra L, Narula J, Reutelingsperger CPM. Counting heads in the war against cancer: defining the role of annexin V imaging in cancer treatment and surveillance. Cancer Res. 2006 66 : 1255 60.
24. Neves AA, Brindle KM. Assessing responses to cancer therapy using molecular imaging. Biochim Biophys Acta. 2006 1766 : 242 61.
25. Blankenberg FG, Katsikis PD, Tait J F, Davis RE, Raumovski L, Ohtsuki K, Kopiwoda S, Abrams MJ, Daekes M, Robbins RC, Maecker HT, Strauss HW. In vivo detection and imaging of phosphatidylserine expression during programmed cell death. Proc Natl Acad Sci USA. 1998 95 : 6349 54.
26. Arap W, Pasqualini R, Ruoslahati. Cancer treatment by targeted drugs delivery to tumor vasculature in a mouse model. Science. 1998 279 : 377 80.
27. Shao R, Xiong C, Wen X, Gelovani JG, Li C. Targeting phosphatidylserine on apoptotic cells with phages and peptides selected from a bacteriophage display library. Mol Imaging. 2007 6 : 417 26.
28. Segers J, Laumonier C, Burtea C, Laurent S, Elst LV, Muller RN. From phage display to magnetophage, a new tool for magnetic resonance molecular imaging. Bioconjugate Chem. 2007 18 : 1251 8.
29. Stach CM, Turnay X, Voll RE, Kern PM, Kolowos W, Beyer TD, Kalden JR, Herrmann M. Treatment with annexin V increases immunogenicity of apoptotic human T-cells in balb/c mice. Cell Death Differ. 2000 7 : 911 5.