메뉴 건너뛰기




Volumn 118, Issue 11, 2008, Pages 1120-1122

Editorial: Inhibition of lipoprotein-associated phospholipase activity by darapladib shifting gears in cardiovascular drug development: are antiinflammatory drugs the next frontier?

Author keywords

Atherosclerosis; Drugs; Editorials; Inflammation; Lipids

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ATORVASTATIN; C REACTIVE PROTEIN; DARAPLADIB; GELATINASE B; INTERLEUKIN 6; MYELOPEROXIDASE; PLACEBO; ANTIINFLAMMATORY AGENT; BENZALDEHYDE DERIVATIVE; CARDIOVASCULAR AGENT; ENZYME INHIBITOR; OXIME;

EID: 54049108847     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.108.795195     Document Type: Editorial
Times cited : (13)

References (22)
  • 2
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group
    • Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344:1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 4
    • 38949210220 scopus 로고    scopus 로고
    • Effect of a mul- tifactorial intervention on mortality in type 2 diabetes
    • Gaede P, Lund-Andersen H, Parving HH, Pedersen O. Effect of a mul- tifactorial intervention on mortality in type 2 diabetes. N Engl J Med.2008;358:580-591.
    • (2008) N Engl J Med , vol.358 , pp. 580-591
    • Gaede, P.1    Lund-Andersen, H.2    Parving, H.H.3    Pedersen, O.4
  • 6
    • 43849103005 scopus 로고    scopus 로고
    • Effects of succinobucol (AGI-1067) after an acute coronary syndrome: A randomised, double-blind, placebo-controlled trial
    • for the Aggressive Reduction of Inflammation Stops Events (ARISE) Trial Investigators
    • Tardif JC, McMurray JJ, Klug E, Small R, Schumi J, Choi J, Cooper J,Scott R, Lewis EF, L'Allier PL, Pfeffer MA, for the Aggressive Reduction of Inflammation Stops Events (ARISE) Trial Investigators. Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial. Lancet. 2008;371:1761-1768.
    • (2008) Lancet , vol.371 , pp. 1761-1768
    • Tardif, J.C.1    McMurray, J.J.2    Klug, E.3    Small, R.4    Schumi, J.5    Choi, J.6    Cooper, J.7    Scott, R.8    Lewis, E.F.9    L'Allier, P.L.10    Pfeffer, M.A.11
  • 7
    • 18244373708 scopus 로고    scopus 로고
    • Role of lipoprotein-associated phospholipase A2 in atherosclerosis
    • Zalewski A, Macphee C. Role of lipoprotein-associated phospholipase A2 in atherosclerosis. Arterioscler Thromb Vasc Biol. 2005;25:923-931.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 923-931
    • Zalewski, A.1    Macphee, C.2
  • 9
    • 0035929246 scopus 로고    scopus 로고
    • Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages
    • Carpenter KL, Dennis IF, Challis IR, Osborn DP, Macphee CH, Leake DS, Arends MJ, Mitchinson MJ. Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages. FEBS Lett. 2001;505:357-363.
    • (2001) FEBS Lett , vol.505 , pp. 357-363
    • Carpenter, K.L.1    Dennis, I.F.2    Challis, I.R.3    Osborn, D.P.4    Macphee, C.H.5    Leake, D.S.6    Arends, M.J.7    Mitchinson, M.J.8
  • 10
    • 0035933117 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of human platelet- activating factor-acetylhydrolase prevents injury-induced neointima for-mation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice
    • Quarck R, De Geest B, Stengel D, Mertens A, Lox M, Theilmeier G,Michiels C, Raes M, Bult H, Collen D, Van Veldhoven P, Ninio E, Holvoet P. Adenovirus-mediated gene transfer of human platelet- activating factor-acetylhydrolase prevents injury-induced neointima for-mation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2001;103:2495-2500.
    • (2001) Circulation , vol.103 , pp. 2495-2500
    • Quarck, R.1    De Geest, B.2    Stengel, D.3    Mertens, A.4    Lox, M.5    Theilmeier, G.6    Michiels, C.7    Raes, M.8    Bult, H.9    Collen, D.10    Van Veldhoven, P.11    Ninio, E.12    Holvoet, P.13
  • 11
    • 35148848559 scopus 로고    scopus 로고
    • New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease
    • Tsimikas S, Tsironis LD, Tselepis AD. New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. Arterioscler Thromb Vasc Biol.2007;27:2094-2099.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2094-2099
    • Tsimikas, S.1    Tsironis, L.D.2    Tselepis, A.D.3
  • 12
    • 2642567931 scopus 로고    scopus 로고
    • Platelet-activating factor acetylhydrolase: Is it good or bad for you?
    • Chen CH. Platelet-activating factor acetylhydrolase: is it good or bad for you? Curr Opin Lipidol. 2004;15:337-341.
    • (2004) Curr Opin Lipidol , vol.15 , pp. 337-341
    • Chen, C.H.1
  • 14
    • 33745965348 scopus 로고    scopus 로고
    • Lipoprotein- associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stress
    • Koenig W, Twardella D, Brenner H, Rothenbacher D. Lipoprotein- associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stress. Arterioscler Thromb Vasc Biol. 2006;26:1586-1593.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1586-1593
    • Koenig, W.1    Twardella, D.2    Brenner, H.3    Rothenbacher, D.4
  • 15
    • 33646685941 scopus 로고    scopus 로고
    • Lipoprotein-associated phospholipase A2 and its association with cardiovascular outcomes in patients with acute coronary syndromes in the PROVE IT-TIMI 22 (Pravastatin or Atorva- statin Evaluation and Infection Therapy-Thrombolysis In MyocardialInfarction) trial
    • O'Donoghue M, Morrow DA, Sabatine MS, Murphy SA, McCabe CH, Cannon CP, Braunwald E. Lipoprotein-associated phospholipase A2 and its association with cardiovascular outcomes in patients with acute coronary syndromes in the PROVE IT-TIMI 22 (Pravastatin or Atorva- statin Evaluation and Infection Therapy-Thrombolysis In MyocardialInfarction) trial. Circulation. 2006;113:1745-1752.
    • (2006) Circulation , vol.113 , pp. 1745-1752
    • O'Donoghue, M.1    Morrow, D.A.2    Sabatine, M.S.3    Murphy, S.A.4    McCabe, C.H.5    Cannon, C.P.6    Braunwald, E.7
  • 16
    • 43049122963 scopus 로고    scopus 로고
    • The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk equivalent: The results of a multi- center, randomized, double-blind, placebo-controlled study
    • for the Darapladib Investigators
    • Mohler ER, Ballantyne CM, Davidson MH, Hanefeld M, Ruilope LM, Johnson JL, Zalewski A, for the Darapladib Investigators. The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk equivalent: the results of a multi- center, randomized, double-blind, placebo-controlled study. J Am CollCardiol. 2008;51:1632-1641.
    • (2008) J Am CollCardiol , vol.51 , pp. 1632-1641
    • Mohler, E.R.1    Ballantyne, C.M.2    Davidson, M.H.3    Hanefeld, M.4    Ruilope, L.M.5    Johnson, J.L.6    Zalewski, A.7
  • 17
    • 54049152760 scopus 로고    scopus 로고
    • B0tker HE, von Birgelen C, D'Amico D, Hutchinson T, Zambanini A, Mastik F, van Es G-A, van der Steen AFW, Vince DG, Ganz P, Hamm CW, Wijns W, Zalewski A, for the Integrated Biomarker and Imaging Study-2 Investigators. Effects of the direct lipoprotein-associated phospholipase A2 inhibitor darapladib on human coronary atherosclerotic plaque
    • Serruys PW, Garcia-Garcia HM, Buszman P, Erne P, Verheye S, Aschermann M, Duckers H, Bleie O, Dudek D, B0tker HE, von Birgelen C, D'Amico D, Hutchinson T, Zambanini A, Mastik F, van Es G-A, van der Steen AFW, Vince DG, Ganz P, Hamm CW, Wijns W, Zalewski A, for the Integrated Biomarker and Imaging Study-2 Investigators. Effects of the direct lipoprotein-associated phospholipase A2 inhibitor darapladib on human coronary atherosclerotic plaque. Circulation. 2008;118:1172-1182.
    • (2008) Circulation , vol.118 , pp. 1172-1182
    • Serruys, P.W.1    Garcia-Garcia, H.M.2    Buszman, P.3    Erne, P.4    Verheye, S.5    Aschermann, M.6    Duckers, H.7    Bleie, O.8    Dudek, D.9
  • 18
    • 0034622623 scopus 로고    scopus 로고
    • Characterization of plaque components with intravascular ultrasound elastography in human femoral and coronary arteries in vitro
    • de Korte CL, Pasterkamp G, van der Steen AF, Woutman HA, Born N. Characterization of plaque components with intravascular ultrasound elastography in human femoral and coronary arteries in vitro. Circulation.2000;102: 617-623.
    • (2000) Circulation , vol.102 , pp. 617-623
    • de Korte, C.L.1    Pasterkamp, G.2    van der Steen, A.F.3    Woutman, H.A.4    Born, N.5
  • 21
    • 34548438881 scopus 로고    scopus 로고
    • Comparison of virtual histology to intravascular ultrasound of culprit coronary lesions in acute coronary syndrome and target coronary lesions in stable angina pectoris
    • Hong MK, Mintz GS, Lee CW, Suh J, Kim JH, Park DW, Lee SW, Kim YH, Cheong SS, Kim JJ, Park SW, Park SJ. Comparison of virtual histology to intravascular ultrasound of culprit coronary lesions in acute coronary syndrome and target coronary lesions in stable angina pectoris. Am J Cardiol. 2007;100:953-959.
    • (2007) Am J Cardiol , vol.100 , pp. 953-959
    • Hong, M.K.1    Mintz, G.S.2    Lee, C.W.3    Suh, J.4    Kim, J.H.5    Park, D.W.6    Lee, S.W.7    Kim, Y.H.8    Cheong, S.S.9    Kim, J.J.10    Park, S.W.11    Park, S.J.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.