Effects of methadone, alone or in combination with acepromazine or xylazine, on sedation and physiologic values in dogs

Veterinary Anaesthesia and Analgesia

Volumn 35, Issue 6, 2008, Pages 519-527

  Monteiro, Eduardo R ^a,c   Figueroa, Christian D N ^a   Choma, Jeison C ^a   Campagnol, Daniela ^b   Bettini, Carlos M ^a  

^a Aperfeiçoamento em Osteopatia em andamento na Escuela de Osteopatia de Madrid   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c Cesumar Hospital Veterinário   (Brazil)

Author keywords

Acepromazine; Dog; Methadone; Sedation; Xylazine

Indexed keywords

ANIMALIA; CANIS FAMILIARIS;

EID: 54049106868     PISSN: 14672987     EISSN: 14672995     Source Type: Journal    
DOI: 10.1111/j.1467-2995.2008.00412.x     Document Type: Article

References (33)

1. Ansah OB, Raekallio M, Vainio O (1998) Comparison of three doses of dexmedetomidine with medetomidine in cats following intramuscular administration. J Vet Pharmacol Ther 21, 380 387.
2. Blancquaert JP, Lefebvre RA, Willems JL (1986) Emetic and antiemetic effects of opioids in the dog. Eur J Pharmacol 128, 143 150.
3. Cornick JL, Hartsfield SM (1992) Cardiopulmonary and behavioral effects of combinations of acepromazine/butorphanol and acepromazine/oxymorphone in dogs. J Am Vet Med Assoc 200, 1952 1956.
4. Dyson D, Pettifer G (1997) Evaluation of the arrhythmogenicity of a low dose of acepromazine: comparison with xylazine. Can J Vet Res 61, 241 245.
5. England GC, Hammond R (1997) Dose-sparing effects of romifidine premedication for thiopentone and halothane anaesthesia in the dog. J Small Anim Pract 38, 141 146.
6. Ewing KK, Mohammed HO, Scarlett JM et al. (1993) Reduction of isoflurane anesthetic requirement by medetomidine and its restoration by atipamezole in dogs. Am J Vet Res 54, 294 299.
7. 2-adrenergic agonists, and related agents. In : Veterinary Pharmacology and Therapeutics 8th edn). Adams HR (ed University Press, Ames, IA, USA. pp. 299 342.
8. Gutstein HB, Akil H (2001) Opioid analgesics. In : Goodman & Gilman's: The Pharmacological Basis of Therapeutics 10th edn). Hardman JG, Limbird LE (eds). McGraw-Hill, New York, USA. pp. 569 619.
9. Hall LW, Clarke KW, Trim CM (eds 2001a) Anaesthesia of the dog. In : Veterinary Anaesthesia 10th edn). WB Saunders, London, UK. pp. 385 439.
10. Hall LW, Clarke KW, Trim CM (eds 2001b) Principles of sedation, analgesia and premedication. In : Veterinary Anaesthesia 10th edn). WB Saunders, London, UK. pp. 75 112.
11. Haskins SC (1996) Monitoring the anesthetized patient. In : Lumb & Jones' Veterinary Anesthesia 3rd edn). Thurmon JC, Tranquilli WJ, Benson GJ (eds). Lippincott Williams & Wilkins, Philadelphia, PA, USA. pp. 409 424.
12. Haskins SC, Patz JD, Farver TB (1986) Xylazine and xylazine-ketamine in dogs. Am J Vet Res 47, 636 641.
13. Heard DJ, Webb AI, Daniels RT (1986) Effect of acepromazine on the anesthetic requirement of halothane in the dog. Am J Vet Res 47, 2113 2115.
14. Hsu WH, Lu ZX, Hembrough FB (1985) Effect of xylazine on heart rate and arterial blood pressure in conscious dogs, as influenced by atropine, 4-aminopyridine, doxapram, and yohimbine. J Am Vet Med Assoc 186, 153 156.
15. Klide AM, Calderwood HW, Soma LR (1975) Cardiopulmonary effects of xylazine in dogs. Am J Vet Res 36, 931 935.
16. Kramer S, Nolte I, Jochle W (1996) Clinical comparison of medetomidine with xylazine/l-methadone in dogs. Vet Rec 138, 128 133.
17. Lemke KA (2004) Perioperative use of selective alpha-2 agonists and antagonists in small animals. Can Vet J 45, 475 480.
18. Ludders JW, Reitan JA, Martucci R et al. (1983) Blood pressure response to phenylephrine infusion in halothane-anesthetized dogs given acetylpromazine maleate. Am J Vet Res 44, 996 999.
19. Monteiro ER, Teixeira Neto FJ, Castro VB et al. (2007) Effects of acepromazine on the cardiovascular actions of dopamine in anesthetized dogs. Vet Anaesth Analg 34, 312 321.
20. Popovic NA, Mullane JF, Yhap EO (1972) Effects of acetylpromazine maleate on certain cardiorespiratory responses in dogs. Am J Vet Res 33, 1819 1824.
21. Pypendop BH, Verstegen JP (1998) Hemodynamic effects of medetomidine in the dog: a dose titration study. Vet Surg 27, 612 622.
22. Pypendop BH, Verstegen JP (2001) Cardiovascular effects of romifidine in dogs. Am J Vet Res 62, 490 495.
23. Robinson EP, Faggella AM, Henry DP et al. (1988) Comparison of histamine release induced by morphine and oxymorphone administration in dogs. Am J Vet Res 49, 1699 1701.
24. Sano T, Nishimura R, Mochizuki M et al. (2003) Effects of midazolam-butorphanol, acepromazine-butorphanol and medetomidine on an induction dose of propofol and their compatibility in dogs. J Vet Med Sci 65, 1141 1143.
25. Smith LJ, Yu JKA, Bjorling DE et al. (2001) Effects of hydromorphone or oxymorphone, with or without acepromazine, on preanesthetic sedation, physiologic values, and histamine release in dogs. J Am Vet Med Assoc 218, 1101 1105.
26. Stanley TH, Liu WS, Webster LR et al. (1980) Haemodynamic effects of intravenous methadone anaesthesia in dogs. Can Anaesth Soc J 27, 52 57.
27. Stepien RL, Bonagura JD, Bednarski RM et al. (1995) Cardiorespiratory effects of acepromazine maleate and buprenorphine hydrochloride in clinically normal dogs. Am J Vet Res 56, 78 84.
28. Thurmon JC, Tranquilli WJ, Benson GJ (eds 1996) Preanesthetics and anesthetic adjuncts. In : Lumb & Jones' Veterinary Anesthesia 3rd edn). Lippincott Williams & Wilkins, Philadelphia, PA, USA. pp. 183 209.
29. Tranquilli WJ, Thurmon JC, Corbin JE et al. (1984) Halothane-sparing effect of xylazine in dogs and subsequent reversal with tolazoline. J Vet Pharmacol Ther 7, 23 28.
30. Turner DM, Ilkiw JE, Rose RJ et al. (1974) Respiratory and cardiovascular effects of five drugs used as sedatives in the dog. Aust Vet J 50, 260 265.
31. Valverde A, Cantwell S, Hernández J et al. (2004) Effects of acepromazine on the incidence of vomiting associated with opioid administration in dogs. Vet Anaesth Analg 31, 40 45.
32. Virtanen R (1989) Pharmacological profiles of medetomidine and its antagonist, atipamezole. Acta Vet Scand 85 (Suppl. 29 37.
33. Wagner AE (2002) Opioids. In : Veterinary Pain Management 1st edn). Gaynor JS, Muir WW (eds). Mosby, St. Louis, MO, USA. pp. 164 183.