Comparison of three doses of dexmedetomidine with medetomidine in cats following intramuscular administration

Journal of Veterinary Pharmacology and Therapeutics

Volumn 21, Issue 5, 1998, Pages 380-387

  Ansah, O B ^a   Raekallio, M ^a   Vainio, O ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b ORION CORPORATION   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

DEXMEDETOMIDINE; MEDETOMIDINE;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; BREATHING RATE; CAT; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HEART RATE; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; MUSCLE RELAXATION; NONHUMAN; PRIORITY JOURNAL; RECTUM TEMPERATURE; SEDATION;

ANALGESICS, NON-NARCOTIC; ANIMALS; CATS; CONSCIOUS SEDATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; IMIDAZOLES; INJECTIONS, INTRAMUSCULAR; MALE; MEDETOMIDINE; MOTOR ACTIVITY; MUSCLE RELAXATION; RESPIRATION;

ANIMALIA; FELIS CATUS;

EID: 0031793111     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.1998.00155.x     Document Type: Article

References (28)

1. Baggot, J.D. (1991) Mechanisms of drug action. In Veterinary Pharmacology and Therapeutics. 6th edn. Eds Booth, N.H. & McDonald L.E. pp. 25-37. Iowa State University Press, Ames.
2. Baggot, J.D. (1995) Pharmacokinetics: Disposition and fate of drugs in the body. In Veterinary Pharmacology and Therapeutics. 7th edn. Ed. Adams H.R. pp. 18-52. Iowa State University Press, Ames.
3. Chow, S-C. & Liu, J-P. (1995) Current issues in bioequivalence trials. Drug Information Journal, 29, 795-804.
4. 2-receptors in the CNS: Studies with mianserin. Archives Internationales de Pharmacodynamie et de Thérapie, 242, 59-76.
5. Doze, V.A., Chen, B-X. & Maze, M. (1989) Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors. Anesthesiology, 71, 75-79.
6. 2 adrenoceptor agonist. Anesthesiology, 75, 252-256.
7. Jones, B., Jarvis, P., Lewis, J.A. & Ebbutt, A.F. (1996) Trials to assess equivalence: the importance of rigorous methods. British Medical Journal, 313, 36-39.
8. Kharasch, E.D., Hill, H.F. & Eddy, A.C. (1991) Influence of dexmedetomidine and clonidine on human liver alfentanil metabolism. Anesthesiology, 75, 520-524.
9. Kharasch, E.D., Hermann, S. & Labroo, R. (1992) Ketamine as a probe for medetomidine stereoisomer inhibition of human liver microsomal drug metabolism. Anesthesiology, 77, 1208-1214.
10. Kitchell, R.L. (1987) Problems in defining pain and the peripheral mechanisms of pain. Journal of the American Veterinary Medical Association, 191, 1195-1199.
11. MacDonald, E., Scheinin, H. & Scheinin, M. (1988) Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative. European Journal of Pharmacology, 158, 119-127.
12. MacDonald, E., Scheinin, M., Scheinin, H. & Virtanen, R. (1991) Comparison of the behavioural and neurochemical effects of the two optical enantiomers of medetomidine, a selective alpha-2-adrenoceptor agonist. Journal of Pharmacology and Experimental Therapeutics, 259, 848-854.
13. Pelkonen, O., Puurunen, J., Arvela, P. & Lammintausta, R. (1991) Comparative effects of medetomidine on in vitro and in vivo microsomal drug metabolism. Pharmacology and Toxicology, 69, 189-194.
14. 2-adrenoceptor agonist in various pain tests. European Journal of Pharmacology, 179, 323-528.
15. Pertovaara, A., Kauppila, T., Jyväsjärvi, E. & Kalso, E. (1991) Involvement of supraspinal and spinal segmental alpha-2-adrenergic mechanisms in the medetomidine-induced antinociception. Neuroscience, 44, 705-714.
16. Sabbe, M.B., Penning, J.P., Ozaki, G.T. & Yaksh, T.L. (1994) Spinal and systemic action of the alpha-2-receptor agonist dexmedetomidine in dogs. Antinociception and carbon dioxide response. Anesthesiology, 80, 1057-1072.
17. Salonen, J.S. (1989) Pharmacokinetics of medetomidine. Acta Veterinaria Scandinavica, 85, 49-54.
18. 2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine. European Journal of Pharmacology, 195, 193-199.
19. Scheinin, H., Karhuvaara, S., Olkkola, K.T., Kallio, A., Anttila, M., Vuorilehto, L. & Scheinin, M. (1992) Pharmacodynamics and pharmacokinetics of intramuscular dexmedetomidine. Clinical Pharmacology and Therapeutics, 52, 537-546.
20. 2-adrenergic agonist medetomidine on systemic and coronary hemodynamics in conscious dogs. Anesthesiology, 75, 499-511.
21. Schwinn, D.A., Correa-Sales, C., Page, S.O., & Maze, M. (1991) Functional effects of activation of alpha-1 adrenoceptors by dexmedetomidine: In vivo and in vitro studies. Journal of Pharmacology and Experimental Therapeutics, 259, 1147-1152.
22. Segal, I.S., Vickery, R.G., Walton, J.K., Doze, V.A. & Maze, M. (1988) Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha-2-adrenergic receptor. Anesthesiology, 69, 818-823.
23. Stenberg, D. (1986) The role of alpha-adrenoceptors in the regulation of vigilance and pain. Acta Veterinaria Scandinavica, 82, 29-34.
24. 2-adrenoceptors in the regulation of vigilance and pain: effects of medetomidine. Acta Veterinaria Scandinavica, 85, 21-28.
25. Vainio, O., Palmu, L., Virtanen, R. & Wecksell, J. (1986/7) Medetomidine, a new sedative and analgesic drug for dogs and cats. Journal of the Association of Veterinary Anaesthetists, 14, 53-55.
26. Vainio, O., Vähä-Vahe, T. & Palmu, L. (1989) Sedative and analgesic effects of medetomidine in dogs. Journal of Veterinary Pharmacology and Therapeutics, 12, 225-231.
27. Vickery, R.G. & Maze, M. (1989) Action of the stereoisomers of medetomidine in halothane-anesthetized dogs. Acta Veterinaria Scandinavica, 85, 71-76.
28. 2-adrenoceptor agonist. European Journal of Pharmacology, 150, 9-14.