Central A1-receptor activation associated with onset of torpor protects the heart against low temperature in the Syrian hamster

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 3, 2008, Pages

  Miyazawa, Seiji ^a   Shimizu, Yasutake ^a   Shiina, Takahiko ^a   Hirayama, Haruko ^a   Morita, Hironobu ^a   Takewaki, Tadashi ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

Arrhythmia; Electrocardiogram; Hypothermia; J wave; Torpor

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; PENTOBARBITAL; ADENOSINE; DRUG DERIVATIVE; HYPNOTIC SEDATIVE AGENT; N(6) CYCLOHEXYLADENOSINE; N(6)-CYCLOHEXYLADENOSINE;

ACCLIMATIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATRIOVENTRICULAR BLOCK; BODY TEMPERATURE; CONTROLLED STUDY; COOLING; CRYOANESTHESIA; ELECTROCARDIOGRAM; FEMALE; HEART; HEART MUSCLE INJURY; HIBERNATION; HYPOTHERMIA; LOW TEMPERATURE; MALE; NONHUMAN; PRIORITY JOURNAL; SYRIAN HAMSTER; ADAPTATION; ANIMAL; COLD; DRUG POTENTIATION; ELECTROCARDIOGRAPHY; HAMSTER; PATHOPHYSIOLOGY; PHODOPUS; PHYSIOLOGY; SEASON;

ACCLIMATIZATION; ADENOSINE; ANIMALS; COLD; CRICETINAE; ELECTROCARDIOGRAPHY; ESTIVATION; HEART; HIBERNATION; HYPNOTICS AND SEDATIVES; HYPOTHERMIA; PENTOBARBITAL; PHODOPUS; RECEPTOR, ADENOSINE A1; SEASONS;

EID: 54049103596     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00142.2008     Document Type: Article

References (38)

1. Alekseev AE, Markevich NI, Korystova AF, Terzic A, Kokoz YM. Comparative analysis of the kinetic characteristics of L-type calcium channels in cardiac cells of hibernators. Biophys J 70: 786-797, 1996.
2. Belke DD, Milner RE, Wang LC. Seasonal variations in the rate and capacity of cardiac SR calcium accumulation in a hibernating species. Cryobiology 28: 354-363, 1991.
3. Brauch KM, Dhruv ND, Hanse EA, Andrews MT. Digital transcriptome analysis indicates adaptive mechanisms in the heart of a hibernating mammal. Physiol Genomics 23: 227-234, 2005.
4. Brunson CE, Abbud E, Osman K, Skelton TN, Markov AK. Osborn (J) wave appearance on the electrocardiogram in relation to potassium transfer and myocardial metabolism during hypothermia. J Investig Med 53: 434-437, 2005.
5. Caprette DR, Senturia JB. Isovolumetric performance of isolated ground squirrel and rat hearts at low temperature. Am J Physiol Regul Integr Comp Physiol 247: R722-R727, 1984.
6. Carey HV, Andrews MT, Martin SL. Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature. Physiol Rev 83: 1153-1181, 2003.
7. Dibb KM, Hagarty CL, Loudon AS, Trafford AW. Photoperioddependent modulation of cardiac excitation contraction coupling in the Siberian hamster. Am J Physiol Regul Integr Comp Physiol 288: R607-R614, 2005.
8. Duker GD, Olsson SO, Hecht NH, Senturia JB, Johansson BW. Ventricular fibrillation in hibernators and nonhibernators. Cryobiology 20: 407-420, 1983.
9. Fedorov VV, Li L, Glukhov A, Shishkina I, Aliev RR, Mikheeva T, Nikolski VP, Rosenshtraukh LV, Efimov IR. Hibernator Citellus undulatus maintains safe cardiac conduction and is protected against tachyarrhythmias during extreme hypothermia: possible role of Cx43 and Cx45 up-regulation. Heart Rhythm 2: 966-975, 2005.
10. Geiser F. Reduction of metabolism during hibernation and daily torpor in mammals and birds: temperature effect or physiological inhibition? J Comp Physiol 158: 25-37, 1988.
11. Ghelardoni S, Carnicelli V, Frascarelli S, Lankford A, Masala I, Ronca-Testoni S, Matherne GP, Zucchi R. Effects of A1 adenosine receptor stimulation on the expression of genes involved in calcium homeostasis. J Mol Cell Cardiol 39: 964-971, 2005.
12. Grant RJ, Clarke PB. Susceptibility of ascending dopamine projections to 6-hydroxydopamine in rats: effect of hypothermia. Neuroscience 115: 1281-1294, 2002.
13. Gussak I, Bjerregaard P, Egan TM, Chaitman BR. ECG phenomenon called the J wave. History, pathophysiology, and clinical significance. J Electrocardiol 28: 49-58, 1995.
14. Harris MB, Milsom WK. Parasympathetic influence on heart rate in euthermic and hibernating ground squirrels. J Exp Biol 198: 931-937, 1995.
15. Johansson BW. The hibernator heart-nature's model of resistance to ventricular fibrillation. Cardiovasc Res 31: 826-832, 1996.
16. Kiyatkin EA. Brain temperature fluctuations during physiological and pathological conditions. Eur J Appl Physiol 101: 3-17, 2007.
17. Kondo N. Excitation-contraction coupling in myocardium of nonhibernating and hibernating chipmunks: effects of isoprenaline, a high calcium medium, and ryanodine. Circ Res 59: 221-228, 1986.
18. Kondo N. Identification of a pre-hibernating state in myocardium from nonhibernating chipmunks. Experientia 43: 873-875, 1987.
19. Kondo N, Kondo J. Identification of novel blood proteins specific for mammalian hibernation. J Biol Chem 267: 473-478, 1992.
20. Kondo N, Shibata S. Calcium source for excitation-contraction coupling in myocardium of nonhibernating and hibernating chipmunks. Science 225: 641-643, 1984.
21. Lee HH, Koh HC, Chae SL, Kang JS, Lee CH, Paik DJ, Shin IC. Modification of cardiovascular responses to adenosine A1 receptor stimulation in the posterior hypothalamus of anaesthetized rats by cAMP and by GABA(B) receptor blockade. J Auton Pharmacol 21: 249-254, 2001.
22. Mattu A, Brady WJ, Perron AD. Electrocardiographic manifestations of hypothermia. Am J Emerg Med 20: 314-326, 2002.
23. Mertens A, Stiedl O, Steinlechner S, Meyer M. Cardiac dynamics during daily torpor in the Djungarian hamster (Phodopus sungorus). Am J Physiol Regul Integr Comp Physiol 294: R639-R650, 2008.
24. Miller EJ, Li J, Leng L, McDonald C, Atsumi T, Bucala R, Young LH. Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature 451: 578-582, 2008.
25. Milsom WK, Burlington RF, Burleson ML. Vagal influence on heart rate in hibernating ground squirrels. J Exp Biol 185: 25-32, 1993.
26. Milsom WK, Zimmer MB, Harris MB. Regulation of cardiac rhythm in hibernating mammals. Comp Biochem Physiol A 124: 383-391, 1999.
27. Morin LP, Wood PI. A Stereotaxic Atlas of the Golden Hamster Brain. San Diego, CA: Academic, 2001.
28. Morrison RR, Teng B, Oldenburg PJ, Katwa LC, Schnermann JB, Mustafa SJ. Effects of targeted deletion of A1 adenosine receptors on postischemic cardiac function and expression of adenosine receptor subtypes. Am J Physiol Heart Circ Physiol 291: H1875-H1882, 2006.
29. Osborn JJ. Experimental hypothermia; respiratory and blood pH changes in relation to cardiac function. Am J Physiol 175: 389-398, 1953.
30. Saito H, Thapaliya S, Matsuyama H, Nishimura M, Unno T, Komori S, Takewaki T. Reversible impairment of endothelium-dependent relaxation in golden hamster carotid arteries during hibernation. J Physiol 540: 285-294, 2002.
31. Saitongdee P, Milner P, Becker DL, Knight GE, Burnstock G. Increased connexin43 gap junction protein in hamster cardiomyocytes during cold acclimatization and hibernation. Cardiovasc Res 47: 108-115, 2000.
32. Scislo TJ, O'Leary DS. Purinergic mechanisms of the nucleus of the solitary tract and neural cardiovascular control. Neurol Res 27: 182-194, 2005.
33. Shimizu Y, Saito M. Activation of brown adipose tissue thermogenesis in recovery from anesthetic hypothermia in rats. Am J Physiol Regul Integr Comp Physiol 261: R301-R304, 1991.
34. Solomon A, Barish RA, Browne B, Tso E. The electrocardiographic features of hypothermia. J Emerg Med 7: 169-173, 1989.
35. Tamura Y, Shintani M, Nakamura A, Monden M, Shiomi H. Phase-specific central regulatory systems of hibernation in Syrian hamsters. Brain Res 1045: 88-96, 2005.
36. Tseng CJ, Ger LP, Lin HC, Tung CS. Attenuated cardiovascular response to adenosine in the brain stem nuclei of spontaneously hypertensive rats. Hypertension 25: 278-282, 1995.
37. Wang SQ, Lakatta EG, Cheng H, Zhou ZQ. Adaptive mechanisms of intracellular calcium homeostasis in mammalian hibernators. J Exp Biol 205: 2957-2962, 2002.
38. 2+ handling in myocardium of true hibernating mammals. Am J Physiol Heart Circ Physiol 286: H2219-H2228, 2004.