Renal expression and localization of SLC9A3 sodium/hydrogen exchanger and its possible role in acid-base regulation in freshwater rainbow trout (Oncorhynchus mykiss)

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 3, 2008, Pages

  Ivanis, Goran ^a   Braun, Marvin ^a   Perry, Steve F ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Acidosis; Bicarbonate reabsorption; Cortisol; Kidney; Proximal tubule; SLC9; Sodium hydrogen exchange; Sodium hydrogen exchanger

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BICARBONATE; HYDROCORTISONE; MESSENGER RNA; SODIUM PROTON EXCHANGE PROTEIN 2; SODIUM PROTON EXCHANGE PROTEIN 3; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); HYDROGEN; SODIUM; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER 3;

ACID BASE BALANCE; ADULT ANIMAL; APICAL MEMBRANE; ARTICLE; CONTROLLED STUDY; HISTOLOGY; HYDROCORTISONE BLOOD LEVEL; HYPERCAPNIA; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY; KIDNEY TUBULE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAINBOW TROUT; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING; ACIDOSIS; ANIMAL; BLOOD; GENE EXPRESSION; GENETICS; KIDNEY PROXIMAL TUBULE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACID-BASE EQUILIBRIUM; ACIDOSIS; ANIMALS; BICARBONATES; GENE EXPRESSION; HYDROCORTISONE; HYDROGEN; HYPERCAPNIA; KIDNEY TUBULES, PROXIMAL; ONCORHYNCHUS MYKISS; RNA, MESSENGER; SODIUM; SODIUM-HYDROGEN ANTIPORTER; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 54049101493     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90328.2008     Document Type: Article

References (48)

1. Aronson PS. Ion exchangers mediating NaCl transport in the renal proximal tubule. Cell Biochem Biophys 36: 147-153, 2002.
2. Avella M, Bornancin M. A new analysis of ammonia and sodium transport through the gills of the freshwater rainbow trout (Salmo gairdneri). J Exp Biol 142: 155-175, 1989.
3. + antiporter in OKP cells. Am J Physiol Renal Fluid Electrolyte Physiol 264: F1027-F1031, 1993.
4. Baum M, Quigley R. Glucocorticoids stimulate rabbit proximal convoluted tubule acidification. J Clin Invest 91: 110-114, 1993.
5. Cameron JN. Branchial ion uptake in Arctic grayling: resting values and the effects of acid-base disturbance. J Exp Biol 64: 711-725, 1976.
6. Cameron JN. Regulation of blood pH in teleost fish. Respir Physiol 33: 129-144, 1978.
7. Cameron JN. Body fluid pools, kidney function, and acid-base regulation in the freshwater catfish Ictalurus punctatus. J Exp Biol 86: 171-185, 1980.
8. Cameron JN, Kormanik GA. The acid-base responses of gills and kidneys to infused acid and base loads in the channel catfish, Ictalurus punctatus. J Exp Biol 99: 143-160, 1982.
9. Crocker CE, Farrell AP, Gamperl AK, Cech JJ Jr. Cardiorespiratory responses of white sturgeon to environmental hypercapnia. Am J Physiol Regul Integr Comp Physiol 279: R617-R628, 2000.
10. + buffering and excretion in response to acute hypercapnia in the dogfish Squalus acanthias. Am J Physiol 216: 440-452, 1969.
11. Esbaugh A, Perry SF, Bayaa M, Georgalis T, Nickerson JG, Tufts BL, Gilmour KM. Cytoplasmic carbonic anhydrase isozymes in rainbow trout Oncorhynchus mykiss: comparative physiology and molecular evolution. J Exp Biol 208: 1951-1961, 2005.
12. Evans DH. Mechanisms of acid extrusion by two marine fishes; the teleost, Opsanus beta, and the elasmobranch, Squalus acanthias. J Exp Zool 97: 289-299, 1982.
13. Evans DH, Piermarini PM, Choe KP. The multifunctional fish gill: dominant site of gas exchange, osmoregulation, acid-base regulation, and excretion of nitrogenous waste. Physiol Rev 85: 97-177, 2005.
14. Fenton RA, Knepper MA. Mouse models and the urinary concentrating mechanism in the new millennium. Physiol Rev 87: 1083-1112, 2007.
15. Fivelstad S, Olsen AB, Kloften H, Ski H, Stefansson S. Effects of carbon dioxide on Atlantic salmon (Salmo salar L.) smolts at constant pH in bicarbonate rich freshwater. Aquaculture 178: 171-187, 1999.
16. Georgalis T, Yorston J, Gilmour KM, Perry SF. The roles of cytosolic and membrane bound carbonic anhydrase in the renal control of acid-base balance in rainbow trout, Oncorhynchus mykiss. Am J Physiol Renal Physiol 291: F407-F421, 2006.
17. Goss GG, Perry SF. Physiological and morphological regulation of acid-base status during hypercapnia in rainbow trout (Oncorhynchus mykiss). Can J Zool 71: 1673-1680, 1993.
18. + exchangers. Ann NY Acad Sci 976: 248-258, 2002.
19. Hirata T, Kaneko T, Ono T, Nakazato T, Furukawa N, Hasegawa S, Wakabayashi S, Shigekawa M, Chang MH, Romero MF, Hirose S. Mechanism of acid adaptation of a fish living in a pH 3.5 lake. Am J Physiol Regul Integr Comp Physiol 284: R1199-R1212, 2003.
20. Ivanis G, Esbaugh AJ, Perry SF. Branchial expression and localization of SLC9A2 and SLC9A3 sodium/hydrogen exchangers and their possible role in acid-base regulation in freshwater rainbow trout (Oncorhynchus mykiss). J Exp Biol 211: 2467-2477, 2008.
21. + exchanger Nhe3 gene. J Biol Chem 271: 10551-10559, 1996.
22. Katoh F, Hyodo S, Kaneko T. Vacuolar-type proton pump in the basolateral plasma membrane energizes ion uptake in branchial mitochondria-rich cells of killifish Fundulus heteroclitus, adapted to a low ion environment. J Exp Biol 206: 793-803, 2003.
23. Knepper MA, Brooks HL. Regulation of the sodium transporters NHE3, NKCC2 and NCC in the kidney. Curr Opin Nephrol Hypertens 10: 655-659, 2001.
24. Kobayashi KA, Wood CM. The response of the kidney of the freshwater rainbow trout to true metabolic acidosis. J Exp Biol 84: 227-244, 1980.
25. Krogh A. The active absorption of ions in some freshwater animals. Z Vergl Physiol 25: 335-350, 1938.
26. Laghmani K, Preisig PA, Moe OW, Yanagisawa M, Alpern RJ. Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis. J Clin Invest 107: 1563-1569, 2001.
27. Li XC, Zhuo JL. Selective knockdown of AT1 receptors by RNA interference inhibits Val5-ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells. Am J Physiol Cell Physiol 293: C367-C378, 2007.
28. + excretion in the marine teleost, Parophrys vetulus. J Exp Biol 98: 403-414, 1982.
29. McDonald DG, Wood CM. Branchial and renal acid and ion fluxes in the rainbow trout, Salmo gairdneri, at low environmental pH. J Exp Biol 93: 101-118, 1981.
30. Mckenzie DJ, Taylor EW, Dalla Valle AZ, Steffensen JF. Tolerance of acute hypercapnic acidosis by the European eel (Anguilla anguilla). J Comp Physiol [B] 172: 339-346, 2002.
31. Nakhoul NL, Hamm LL. Vacuolar H(+)-ATPase in the kidney. J Nephrol 15, Suppl 5: S22-S31, 2002.
32. +-ATPase B subunit. J Exp Biol 203: 459-470, 2000.
33. Perry SF, Fryer JN. Proton pumps in the fish gill and kidney. Fish Physiol Biochem 17: 363-369, 1997.
34. +-ATPases in the fish gill and kidney during respiratory acidosis. Biochem Biophys Acta 1618: 175-184, 2003.
35. 2 excretion in fish: unanswered questions and emerging models. Respir Physiol Neurobiol 154: 199-215, 2006.
36. Perry SF, Malone S, Ewing D. Hypercapnic acidosis in rainbow trout (Salmo gairdneri). II. Renal ionic fluxes. Can J Zool 65: 896-902, 1987.
37. Perry SF, Malone S, Ewing D. Hypercapnic acidosis in the rainbow trout (Salmo gairdneri). I. Branchial ionic fluxes and blood acid-base status. Can J Zool 65: 888-895, 1987.
38. Perry SF, Shahsavarani A, Georgalis T, Bayaa M, Furimsky M, Thomas SLY. Channels, pumps and exchangers in the gill and kidney of freshwater fishes: their role in ionic and acid-base regulation. J Exp Zool 300: 53-62, 2003.
39. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: 2002-2007, 2001.
40. - cotransporters: cloning and physiology. Annu Rev Physiol 61: 699-723, 1999.
41. Schwartz GJ. Physiology and molecular biology of renal carbonic anhydrase. J Nephrol 15, Suppl 5: S61-S74, 2002.
42. +-ATPase. Physiol Rev 84: 1263-1314, 2004.
43. Wheatly MG, Hobe H, Wood CM. The mechanisms of acid-base and ionoregulation in the freshwater rainbow trout during environmental hyperoxia and subsequent normoxia. II. The role of the kidney. Respir Physiol 55: 155-173, 1984.
44. Winkler CA, Kittelberger AM, Schwartz GJ. Expression of carbonic anhydrase IV mRNA in rabbit kidney: stimulation by metabolic acidosis. Am J Physiol 272 (Renal Physiol 41): F551-F560, 1997.
45. Wood CM, Caldwell FH. Renal regulation of acid-base balance in a freshwater fish. J Exp Zool 205: 301-307, 1978.
46. Wood CM, Jackson EB. Blood acid-base regulation during environmental hyperoxia in the rainbow trout (Salmo gairdneri). Respir Physiol 42: 351-372, 1980.
47. Wood CM, Milligan CL, Walsh PJ. Renal responses of trout to chronic respiratory and metabolic acidoses and metabolic alkalosis. Am J Physiol Regul Integr Comp Physiol 277: R482-R492, 1999.
48. + exchange-adaptation to metabolic acidosis. J Biol Chem 271: 32749-32752, 1996.