Oxacyclododecindione, a novel inhibitor of IL-4 signaling from Exserohilum rostratum

Journal of Antibiotics

Volumn 61, Issue 5, 2008, Pages 285-290

  Erkel, Gerhard ^a   Belahmer, Hanane ^a   Serwe, Annegret ^a   Anke, Timm ^a   Kunz, Horst ^b   Kolshorn, Heinz ^b   Liermann, Johannes ^c   Opatz, Till ^c  

^a University of Koblenz Landau   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Exserohilum; Inhibitor; Interleukin 4 signaling; New metabolite

Indexed keywords

ALKALINE PHOSPHATASE; INTERLEUKIN 4; MACROLIDE; OXACYCLODODECINDIONE; STAT6 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; MACROCYCLIC COMPOUND;

ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING SITE; BIOLOGICAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG INHIBITION; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; EXSEROHILUM ROSTRATUM; FUNGUS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION; SPECTROSCOPY; CHEMISTRY; DEUTEROMYCETES; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; FERMENTATION; GENE EXPRESSION; GENETIC TRANSFECTION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; WESTERN BLOTTING;

EXSEROHILUM; EXSEROHILUM ROSTRATUM; FUNGI;

BLOTTING, WESTERN; CELL LINE, TUMOR; FERMENTATION; GENE EXPRESSION; HUMANS; INTERLEUKIN-4; MACROCYCLIC COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; MITOSPORIC FUNGI; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STAT6 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 54049101141     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2008.40     Document Type: Article

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