Synthesis and testing of peptides for anti-prion activity

European Journal of Medicinal Chemistry

Volumn 43, Issue 11, 2008, Pages 2418-2427

  Sellarajah, Shane ^a,b   Boussard, Cyrille ^a   Lekishvili, Tamuna ^c   Brown, David R ^c   Gilbert, Ian H ^a,b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c University of Bath   (United Kingdom)

Author keywords

Peptide; Prion; Transmissible spongiform encephalopathy

Indexed keywords

ALANYLALANYLGLYCYLALANYLALANYLALANYLALANYLGLYCINE; ALANYLALANYLGLYCYLALANYLALANYLALANYLALANYLGLYCYLALANYLVALYLVALINE; ALANYLALANYLGLYCYLALANYLALANYLALANYLALANYLPROLYLGLYCYLALANYLVALYLVALINE; ALANYLALANYLGLYCYLALANYLALANYLALANYLPROLYLGLYCINE; ALANYLALANYLGLYCYLALANYLALANYLALANYLPROLYLGLYCYLALANYLVALYLVALINE; ALANYLALANYLGLYCYLALANYLALANYLALANYLPROLYLGLYCYLPROLINE; ALANYLALANYLPROLYLALANYLALANYLALANYLALANINE; ALANYLALANYLPROLYLALANYLALANYLALANYLALANYLGLYCYLALANYLVALINE; ALANYLALANYLPROLYLALANYLALANYLALANYLALANYLGLYCYLALANYLVALYLVALINE; ALANYLALANYLPROLYLALANYLALANYLALANYLPROLYLGLYCYLALANINE; ALANYLALANYLPROLYLGLYCINE; ALANYLALANYLPROPYLALANYLALANYLALANYLALANYLGLYCINE; ALANYLPROLYLGLYCYLALANYLALANYLALANYLPROLYLGLYCYLALANINE; GLYCYLALANYLALANYLALANYLPROLYLGLYCINE; GLYCYLALANYLALANYLALANYLPROLYLPROLINE; GLYCYLALANYLALANYLPROLYLPROLYLGLYCINE; GLYCYLALANYLPROLYLALANYLPROLYLGLYCINE; GLYCYLPROLYLALANYLALANYLPROLYLGLYCINE; HISTIDYLALANYLALANYLGLYCYLALANYLALANYLALANYLALANYLGLYCYLALANINE; HISTIDYLALANYLALANYLGLYCYLALANYLALANYLALANYLPROLYLGLYCYLALANINE; HISTIDYLALANYLALANYLGLYCYLALANYLALANYLALANYLPROLYLGLYCYLALANYLVALINE; HISTIDYLPROLYLALANYLGLYCYLALANYLALANYLALANYLALANYLGLYCYLALANINE; LYSYLHISTIDYLALANYLALANYLGLYCYLALANYLALANYLALANYLPROLYLGLYCYLALANYLVALYLVALINE; LYSYLHISTIDYLALANYLALANYLPROLYLALANYLALANYLALANYLALANYLGLYCYLALANYLVALYLVALINE; LYSYLHISTIDYLPROLYLALANYLGLYCYLALANYLALANYLALANYLALANYLGLYCYLALANINE; PEPTIDE; PRION PROTEIN; PROLYLALANYLGLYCYLALANYLALANYLALANYLALANYLGLYCINE; PROLYLALANYLGLYCYLALANYLALANYLALANYLALANYLGLYCYLALANYLVALYLVALINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; MOLECULAR MODEL; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; CONSERVED SEQUENCE; CRICETINAE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PRIONS; PROTEIN DENATURATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 54049098830     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.01.041     Document Type: Article

References (32)

1. Bounias M., and Purdey M. Sci. Total Environ. 297 (2002) 1
2. McKintosh E., Tabrizi S.J., and Collinge J. J. Neurovirol. 9 (2003) 183-193
3. Hansen N.J.D. Endoscopy 29 (1997) 584-592
4. Dobson C.M. Protein Pept. Lett. 13 (2006) 219-227
5. Masel J., and Jansen V.A.A. Biophys. Chem. 88 (2000) 47-59
6. Mallucci G., and Collinge J. Nat. Rev. Neurosci. 6 (2005) 23-34
7. Wisniewski T., Brown D.R., and Sigurdsson E.M. Biochem. Soc. Trans. 30 (2002) 574-578
8. Dealler S., and Rainov N.G. IDrugs 6 (2003) 470-478
9. Shirabe S., Satoh K., and Eguchi K.J. Pharmacol. Sci. 91 (2003) 49P
10. Caughey B., Ernst D., and Race R.E. J. Virol. 67 (1993) 6270-6272
11. Caughey B., Brown K., Raymond G.J., Katzenstein G.E., and Thresher W. J. Virol. 68 (1994) 2135-2141
12. Ingrosso L., Ladogana A., and Pocchiari M. J. Virol. 69 (1995) 506-508
13. Rudyk H., Vasiljevic S., Hennion R.M., Birkett C.R., Hope J., and Gilbert I.H. J. Gen. Virol. 81 (2000) 1155-1164
14. Sellarajah S., Lekishvili T., Bowring C., Thompsett A.R., Rudyk H., Birkett C.R., Brown D.R., and Gilbert I.H. J. Med. Chem. 47 (2004) 5515-5534
15. Caughey W.S., Raymond L.D., Horiuchi M., and Caughey B. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 12117-12122
16. Adjou K.T., Deslys J.P., Lasmezas C.I., Demaimay R., Dormont D., and Seman M. Med. Sci. 13 (1997) 892-897
17. Hartsel S.C., and Weiland T.R. Biochemistry 42 (2003) 6228-6233
18. Supattapone S., Nguyen H.O.B., Cohen F.E., Prusiner S.B., and Scott M.R. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 14529-14534
19. Tagliavini F., McArthur R.A., Canciani B., Giaccone G., Porro M., Bugiani M., Lievens P.M.J., Bugiani O., Peri E., DallAra P., Rocchi M., Poli G., Forloni G., Bandiera T., Varasi M., Suarato A., Cassutti P., Cervini M.A., Lansen J., Salmona M., and Post C. Science 276 (1997) 1119-1122
20. Pritchard M.C., Raphy J., and Singh L. Exp. Opin. Invest. Drugs 6 (1997) 349-365
21. Chabry J., Caughey B., and Chesebro B. J. Biol. Chem. 273 (1998) 13203-13207
22. Chabry J., Priola S.A., Wehrly K., Nishio J., Hope J., and Chesebro B. J. Virol. 73 (1999) 6245-6250
23. Yehiely F., Bamborough P., DaCosta M., Perry B.J., Thinakaran G., Cohen F.E., Carlson G.A., and Prusiner S.B. Neurobiol. Dis. 3 (1997) 339-355
24. Lee K.S., Linden R., Prado M.A.M., Brentani R.R., and Martins V.R. Rev. Med. Virol. 13 (2003) 399-408
25. Chenna R., Sugawara H., Koike T., Lopez R., Gibson T.J., Higgins D.G., and Thompson J.D. Nucleic Acids Res. (2003) 497-500
26. Soto C., Kascsak R.J., Saborio G.P., Aucouturier P., Wisniewski T., Prelli F., Kascsak R., Mendez E., Harris D.A., Ironside J., Tagliavini F., Carp R.I., and Frangione B. Lancet 355 (2000) 192-197
27. Martin J.A., Redshaw S., and Thomas G.J. In: Ellis G.P., and Luscombe D.K. (Eds). Progress in Medicinal Chemistry vol. 32 (1995), Elsevier, Amsterdam pp. 239-287
28. Roberts N.A., Martin J.A., Kinchington D., Broadhurst A.V., Craig J.C., Duncan I.B., Galpin S.A., Handa B.K., Kay J., Krohn A., et al. Science 248 (20 April 1990) 358-361
29. Knor S., Khrenov A.V., Laufer B., Saenko E.L., Hauser C.A.E., and Kessler H. J. Med. Chem. 50 (2007) 4329-4339
30. Brown D.R. Biochem. J. 352 (2000) 511-518
31. Brown D.R., Hafiz F., Glasssmith L.L., Wong B.S., Jones I.M., Clive C., and Haswell S.J. EMBO J. 19 (2000) 1180-1186
32. Wong B.S., Wang H., Brown D.R., and Jones I.M. Biochem. Biophys. Res. Commun. 259 (1999) 352-355