Safety and efficacy of intramuscular propofol administration in rats

Veterinary Anaesthesia and Analgesia

Volumn 35, Issue 6, 2008, Pages 495-500

  McKune, Carolyn M ^a   Brosnan, Robert J ^a   Dark, Michael J ^b,c   Haldorson, Gary J ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c Washington Animal Disease Diagnostic Laboratory   (United States)

Author keywords

2,6 diisopropylphenol; Dimethyl sulfoxide; Solubility; Sulfinylbismethane

Indexed keywords

ANIMALIA; RATTUS;

EID: 54049089546     PISSN: 14672987     EISSN: 14672995     Source Type: Journal    
DOI: 10.1111/j.1467-2995.2008.00418.x     Document Type: Article

References (13)

1. Adam HK, Glen JB, Hoyle PA (1980) Pharmacokinetics in laboratory animals of ICI 35 868, a new i.v. anaesthetic agent. Br J Anaesth 52, 743 746.
2. Ecke GG, Kolka AJ (1966) 2,6-Diisopropylphenol 3271314, US Patent Office. pp. 1 4.
3. Glen JB, Hunter SC (1984) Pharmacology of an emulsion formulation of ICI 35 868. Br J Anaesth 56, 617 626.
4. Hucker HB, Ahmad PM, Miller EA (1966) Absorption, distribution and metabolism of dimethylsulfoxide in the rat, rabbit and guinea pig. J Pharmacol Exp Ther 154, 176 184.
5. Mackenzie N, Grant IS 1987) Propofol for intravenous sedation. Anaesthesia 42, 3 6.
6. Mama KR, Steffey EP, Pascoe PJ (1995) Evaluation of propofol as a general anesthetic for horses. Vet Surg 24, 188 194.
7. Mather LE, Selby DG, Runciman WB et al. (1989) Propofol: assay and regional mass balance in the sheep. Xenobiotica 19, 1337 1347.
8. Roth W, Eschertzhuber S, Gardetto A et al. (2006) Extravasation of propofol is associated with tissue necrosis in small children. Paediatr Anaesth 16, 887 889.
9. Schywalsky M, Ihmsen H, Tzabazis A et al. (2003) Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats. Eur J Anaesthesiol 20, 182 190.
10. Short CE, Bufalari A (1999) Propofol anesthesia. Vet Clin North Am Small Anim Pract 29, 747 778.
11. Tokumine J, Sugahara K, Tomori T et al. (2002) Tissue necrosis caused by extravasated propofol. J Anesth 16, 358 359.
12. Trapani A, Laquintana V, Lopedota A et al. (2004) Evaluation of new propofol aqueous solutions for intravenous anesthesia. Int J Pharm 278, 91 98.
13. Zhou JX, Luo NF, Liang XM et al. (2006) The efficacy and safety of intravenous emulsified isoflurane in rats. Anesth Analg 102, 129 134.