Enantioselective analysis of oxybutynin and N-desethyloxybutynin with application to an in vitro biotransformation study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 875, Issue 1, 2008, Pages 161-167

  da Fonseca, Patrícia ^a   de Freitas, Luis Alexandre Pedro ^a   Pinto, Luis Felipe Ribeiro ^b   Pestana, Cezar Rangel ^a   Bonato, Pierina Sueli ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Biotransformation; Enantioseparation; N Desethyloxybutynin; Oxybutynin

Indexed keywords

EXTRACTION; LIVER; SOLVENT EXTRACTION;

BIOTRANSFORMATION; ENANTIOSELECTIVE; ENANTIOSELECTIVE ANALYSES; ENANTIOSEPARATION; EXTRACTION CONDITIONS; HPLC ANALYSES; IN VITRO; N-DESETHYLOXYBUTYNIN; OPTIMIZED USING; OXYBUTYNIN; RAT LIVERS; VALIDATED METHODS;

BIOCONVERSION;

CHOLINERGIC RECEPTOR BLOCKING AGENT; N DESETHYLOXYBUTYNIN; OXYBUTYNIN; UNCLASSIFIED DRUG;

ACCURACY; ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CHIRALITY; DRUG DETERMINATION; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG TRANSFORMATION; ENANTIOSELECTIVITY; FACTORIAL DESIGN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIQUID PHASE MICROEXTRACTION; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; RAT; VALIDATION STUDY;

ANIMALS; BIOTRANSFORMATION; CHEMICAL FRACTIONATION; MALE; MANDELIC ACIDS; MICROSOMES, LIVER; RATS; RATS, WISTAR; STEREOISOMERISM;

RATTUS;

EID: 54049087365     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.05.023     Document Type: Article

References (30)

1. Kim H., and Han S.B. J. Pharm. Biomed. Anal. 31 (2003) 341
2. Miyamoto E., Demizu Y., Murata Y., Yamada Y., and Kawashima S. J. Chromatogr. A 653 (1993) 135
3. Massoud R., Federici G., Casciani S., Di Stasi S.M., Fucci G., Giannantoni A., and Cortese C. J. Chromatogr. B 734 (1999) 163
4. Lukkari E., Taavitsainen P., Juhakoski A., and Pelkonen O. Pharmacol. Toxicol. 82 (1998) 161
5. Zobrist R.H., Schmid B., Feick A., Quan D., and Sanders S.W. Pharm. Res. 18 (2001) 1029
6. Zobrist R.H., Quan D., Thomas H.M., Stanworth S., and Sanders S.W. Pharm. Res. 20 (2003) 103
7. Woolfson A.D., Malcolm R.K., and Gallagher R.J. J. Control. Release 91 (2003) 465
8. Shibukawa A., Ishizawa N., Kimura T., Sakamoto Y., Ogita K., Matsuo Y., Kuroda Y., Matayatsuk C., Nakagawa T., and Wainer I.W. J. Chromatogr. B 768 (2002) 177
9. Mizushima H., Takanaka K., Abe K., Fukazawa I., and Ishizuka H. Xenobiotica 37 (2007) 59
10. Lukkari E., Taavitsainen P., Juhakoski A., and Pelkonen O. Pharmacol. Toxicol. 84 (1998) 161
11. Yaich M., Popon M., Medard Y., and Aigrain E.J. Pharmacogenetics 8 (1998) 449
12. Alebic-Kolbach T., and Zavitsanos A.P. J. Chromatogr. A 759 (1997) 65
13. Pedersen-Bjergaard S., and Rasmussen K.E. J. Chromatogr. B 817 (2005) 3
14. Ho T.S., Reubsaet J.L.E., Anthonsen H.S., Pedersen-Bjergaard S., and Rasmussen K.E. J. Chromatogr. A 1072 (2005) 29
15. Psillakis E., and Kalogerakis N. Trends Anal. Chem. 22 (2003) 565
16. Rasmussen K.E., Pedersen-Bjergaard S., Krogh M., Ugland H.G., and Gronhaug T. J. Chromatogr. A 873 (2000) 3
17. Rasmussen K.E., and Pedersen-Bjergaard S. Trends Anal. Chem. 23 (2004) 1
18. Ferreira S.L.C., Bruns R.E., Silva E.G.P., Santos W.N.L., Quintella C.M., David J.M., Andrade J.B., Breitkreitz M.C., Jardim I.C.S.F., and Neto B.B. J. Chromatogr. A 1158 (2007) 2
19. Neto B.B., Scarminio I.S., and Bruns R.E. Quim. Nova 29 (2006) 1401
20. Mousavi M., Noroozian E., Jalali-Heravi M., and Mollahosseini A. Anal. Chim. Acta 581 (2007) 71
21. Sousa E.T., Rodrigues F.M., Martins C.C., Oliveira F.S., Pereira P.A.P., and Andrade J.B. Microchem. J. 82 (2006) 142
22. Ducharme J., and Farinotti R. J. Chromatogr. B 698 (1997) 243
23. Rosing H., Man W.Y., Doyle E., Bult A., and Beijnen J.H. J. Liq. Chromatogr. Relat. Technol. 23 (2000) 329
24. Lake B.G. In: Snell K., and Mullock B. (Eds). Biochemical Toxicology-A Practical Approach (1987), IRL Press, Oxford, Washington, DC 183
25. Shen G., and Lee H.K. Anal. Chem. 74 (2002) 648
26. Ugland H.G., Krogh M., and Reubsaet L. J. Chromatogr. B 798 (2003) 127
27. FDA, Guidance for Industry: Bioanalytical Methods Validation, May 2001.
28. Bresolle F., Bromet-Petit M., and Audran M. J. Chromatogr. B 686 (1996) 3
29. Causon R. J. Chromatogr. B 689 (1997) 175
30. Lord H., and Pawliszyn J. J. Chromatogr. A 902 (2000) 17