Synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer

Synthesis

Volumn , Issue 19, 2008, Pages 3061-3064

  Bhaskar, Gopishetti ^a   Kumar, Anchoori Ravi ^a   Ramu, Errabelli ^a   Rao, Batchu Venkateswara ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

HIV AIDS; Peptidomimetic aspartyl protease inhibitors; Regioselective epoxide opening

Indexed keywords

DIPEPTIDE ISOSTERE; HIV-AIDS; HIV-PROTEASE INHIBITORS; PEPTIDOMIMETIC ASPARTYL PROTEASE INHIBITORS; REGIOSELECTIVE EPOXIDE OPENING; SYNTHESIS OF;

2,5 BIS[(TERT BUTOXYCARBONYL)AMINO] 1,6 DIPHENYLHEXAN 3 OL; ALUVIRAN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; EPOXIDE; HYDROXYETHYLENE DIPEPTIDE ISOSTERE; LOPINAVIR; PROTEINASE INHIBITOR; RITONAVIR; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; DIASTEREOISOMER; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PROTEINASE INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

EID: 53949115072     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1067252     Document Type: Article

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