Pentoxifylline-supplemented resuscitation attenuates both early and late mediators of hepatic inflammation after hemorrhagic shock

Journal of Organ Dysfunction

Volumn 4, Issue 3, 2008, Pages 177-183

  Deree, Jessica ^a   Loomis, William H ^a   Putnam, James G ^a   Wolf, Paul ^a   Coimbra, Raul ^a  

^a UCSD MEDICAL CENTER   (United States)

Author keywords

Hepatic injury; High mobility group box 1; Inflammation; Ischemia reperfusion; Nitric oxide; Pentoxifylline

Indexed keywords

CYTOKINE; HIGH MOBILITY GROUP B1 PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; PENTOXIFYLLINE; RINGER LACTATE SOLUTION; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOWN REGULATION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMORRHAGIC SHOCK; HYPOTENSION; HYPOVOLEMIC SHOCK; INFLAMMATION; LIVER HISTOLOGY; LIVER INJURY; MALE; MEDIATOR; NONHUMAN; PRIORITY JOURNAL; RAT; RESUSCITATION; SPRAGUE DAWLEY RAT; SUPPLEMENTATION; WESTERN BLOTTING;

RATTUS;

EID: 53949109640     PISSN: 17471060     EISSN: 17471079     Source Type: Journal    
DOI: 10.1080/17471060801931641     Document Type: Article

References (44)

1. Vincent JL. Prevention and therapy of multiple organ failure. World J Surg 1996;20:465-70.
2. Deitch EA. Multiple organ failure: pathophysiology and potential future therapy. Ann Surg 1992;216:117-34.
3. Donelly SC, Robertson C. Mediators, mechanism, and mortality in major trauma. Resuscitation 1994;28:87-92.
4. Roumen RM, Redl H, Schlag G, Zilow G, Sandtner W, Koller W, et al. Inflammatory mediators in relation to the development of multiple organ failure in patients after severe blunt trauma. Crit Care Med 1995;23:474-80.
5. Moore FA. The role of the gastrointestinal tract in postinjury multiple organ failure. Am J Surg 1999;178:449-53.
6. Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW, Moore FA. Post-injury multiple organ failure: the role of the gut. Shock 2001;15:1-10.
7. Pastores SM, Katz DP, Kvetan V. Splanchnic ischemia and gut mucosal injury in sepsis and multiple organ dysfunction syndrome. Am J Gastroenterol 1996;91:1697-710.
8. Swank GM, Deitch EA. Role of the gut in multiple organ failure: bacterial translocation and permeability changes. World J Surg 1996;20:411-7.
9. Taylor BS, Alarcon LH, Billiar TR. Inducible nitric oxide synthase in the liver: regulation and function. Biochemistry 1998;63:766-81.
10. Menezes JM, Hierholzer C, Watkins SC, Billiar TR, Peitzman AB, Harbrecht BG. The modulation of hepatic injury and heat shock expression by inhibition of nitric oxide synthase after hemorrhagic shock. Shock 2002;17:13-8.
11. Hierholzer C, Harbrecht B, Menezes JM, Kane J, MacMicking J, Nathan CF, et al. Essential role of inducible nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med 1998;187:917-28.
12. Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol 2003;284:G15-26.
13. Jaeschke H, Lemasters JJ. Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology 2003;125:1246-57.
14. Wang H, Yang H, Tracey KJ. Extracellular role of HMGB1 in inflammation and sepsis. J Int Med 2004;255:320-31.
15. Erlandsson H, Andersson U. The nuclear protein HMGB1 as a proinflammatory mediator. Eur J Immunol 2004;34:1503-12.
16. Masuno T, Moore EE, Cheng AM, Sarin EL, Banerjee A. Bioactivity of post-shock mesenteric lymph depends on the depth and duration of hemorrhagic shock. Shock 2006;26:285-9.
17. Alam HB, Stanton K, Koustova E, Burris D, Rich N, Rhee P. Effect of different resuscitation strategies on neutrophil activation in a swine model of hemorrhagic shock. Resuscitation 2004;60:91-9.
18. Alam HB, Sun L, Ruff P, Austin B, Burris D, Rhee P. E- and P-selectin expression depends on the resuscitation fluid used in hemorrhaged rats. J Surg Res 2000;94:145-52.
19. Savage SA, Fitzpatrick CM, Kashyap V, Clouse WD, Kerby JD. Endothelial dysfunction after lactated Ringer's solution resuscitation for hemorrhagic shock. J Trauma 2005;59:284-90.
20. Ayuste EC, Chen H, Koustova E, Rhee P, Ahuja N, Chen Z, et al. Hepatic and pulmonary apoptosis after hemorrhagic shock in swine can be reduced through modifications in conventional Ringer's solution. J Trauma 2006;60:52-63.
21. Porter JM, Cutler BS, Le BY. Pentoxifylline efficacy in the treatment of intermittent claudication: multicenter controlled double-blind trial with objective assessment of chronic occlusive arterial disease patients. Am J Heart 1982;104:66-72.
22. Coimbra R, Melbostad H, Hoyt DB. Effects of phosphodiesterase inhibition on the inflammatory response after shock: role of pentoxifylline. J Trauma 2004;56:442-9.
23. Satapathy SK, Garg S, Chauhan R, Sakhuja P, Malhotra V, Sharma BC, et al. Beneficial effects of TNF-α inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2004;99:1946-52.
24. Adams LA, Zein CO, Angulo P, Lindor KD. A pilot trial of pentoxifylline in nonalcoholic steatohepatitis. Am J Gastroenterol 2004;99:2365-8.
25. Wattanasirichaigoon S, Menconi MJ, Fink MP. Lisophylline ameliorates intestinal and hepatic injury induced by hemorrhage and resuscitation in rats. Crit Care Med 2000;28:1540-9.
26. Fabia R, Travis DL, Levy MF, Husberg BS, Goldstein RM, Klintmalm GB. Effect of pentoxifylline on hepatic ischemia and reperfusion injury. Surgery 1997;121:520-5.
27. Coimbra R, Melbostad H, Loomis WH, Porcides R, Wolf P, Tobar M, et al. LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on pro-inflammatory mediators, metalloproteinases, NF-κB, and ICAM-1 expression. J Trauma 2006;60:115-25.
28. Sneed RA, Grimes SD, Schultze AE, Brown AP, Ganey PE. Bacterial endotoxin enhances the hepatotoxicity of allyl alcohol. Toxicol Appl Pharmacol 1997;144:77-87.
29. Kirkeboen KA, Strand OA. The role of nitric oxide in sepsis - an overview. Acta Anaesthesiol Scand 1999;43:275-88.
30. Tsung A, Sahai R, Tanaka H, Nakao A, Fink MP, Lotze MT, et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 2005;210:1135-43.
31. Heckbert SR, Vedder NB, Hoffmann W, Winn RK, Hudson LD, Jurkovich GJ, et al. Outcome after hemorrhagic shock in trauma patients. Am J Physiol 1998;45:545-9.
32. Helling TS. The liver and hemorrhagic shock. J Am Coll Surg 2005;201:774-83.
33. Levy RM, Prince JM, Billiar TM. Nitric oxide: a clinical primer. Crit Care Med 2005;33:S492-5.
34. Takamatsu Y, Shimada K, Yamaguchi K, Kuroki S, Chijiiwa K, Tanaka M. Inhibition of inducible nitric oxide synthase prevents hepatic, but not pulmonary, injury following ischemia-reperfusion injury of rat liver. Dig Dis Sci 2006;51:571-9.
35. Ulloa L, Messmer D. High mobility group box 1 protein: friend and foe. Cytokine Growth Factor Rev 2006;17:189-201.
36. Chen G, Ward MF, Sama AE, Wang H. Extracellular HMGB1 as a proinflammatory cytokine. J Interferon Cytokine Res 2004;24:329-33.
37. Ren D, Sun R, Wang S. Role of inducible nitric oxide synthase expressed by alveolar macrophages in high mobility group box 1-induced acute lung injury. Inflamm Res 2006;55:207-15.
38. Deree J, Loomis WH, Putnam JG, Wolf P, Coimbra R. Phosphodiesterase inhibition downregulates intestinal injury and iNOS activity after hemorrhagic shock. J Org Dysfunct 2008; In press.
39. Deree J, Martins JO, de Campos T, Putnam JG, Loomis WH, Wolf P, et al. Pentoxifylline attenuates lung injury and modulates transcription factor activity in hemorrhagic shock. J Surg Res 2007;143:99-108.
40. Alam HB, Stegalkina S, Rhee P, Koustova E. cDNA array analysis of gene expression following hemorrhagic shock and resuscitation in rats. Resuscitation 2002;54:195-206.
41. Koustova E, Stanton K, Gushchin V, Alam HB, Stegalkina S, Rhee P. Effects of lactated Ringer's solutions on human leukocytes. J Trauma 2002;52:872-8.
42. Cruz RJ, Yada-Langui MM, de Figueiredo LF, Sinosaki S, Roche e Silva M. The synergistic effects of pentoxifylline on systemic and regional perfusion after hemorrhage and hypertonic resuscitation. Anesth Analg 2006;102:1518-24.
43. Miyazaki Y, Saga S, Kondoh Y, Taniguchi H, Taki F, Takagi K, et al. Higher concentrations of matrix metalloproteinases in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 1997;155:43-6.
44. Abdelrahman M, Mazzon E, Bauer M, Bauer I, Delbosc S, Cristol JP, et al. Inhibitors of the NADPH oxidase reduce the organ injury in hemorrhagic shock. Shock 2005;23:107-14.