메뉴 건너뛰기




Volumn 4, Issue 9, 2008, Pages 634-640

The emerging therapeutic role of probiotics in inflammatory bowel disease

Author keywords

Crohn's disease; Inflammatory bowel disease; Pouchitis; Probiotics; Ulcerative colitis

Indexed keywords

AMINOSALICYLIC ACID; CIPROFLOXACIN; CORTICOSTEROID; MESALAZINE; METRONIDAZOLE; PLACEBO; PREDNISOLONE; PROBIOTIC AGENT; RIFAXIMIN; VSL3;

EID: 53849146401     PISSN: 15547914     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (8)

References (61)
  • 3
    • 33847215148 scopus 로고    scopus 로고
    • The role of probiotics in inflammatory bowel disease
    • Jones J, Foxx-Orenstein A. The role of probiotics in inflammatory bowel disease. Dig Dis Sci. 2007;52:607-611.
    • (2007) Dig Dis Sci , vol.52 , pp. 607-611
    • Jones, J.1    Foxx-Orenstein, A.2
  • 4
    • 0029586031 scopus 로고
    • Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
    • Duchmann R, Kaiser I, Hermann E, Mayet W, Ewe K, Meyer zum Büschenfelde KH. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol. 1995;102:448-455.
    • (1995) Clin Exp Immunol , vol.102 , pp. 448-455
    • Duchmann, R.1    Kaiser, I.2    Hermann, E.3    Mayet, W.4    Ewe, K.5    Meyer zum Büschenfelde, K.H.6
  • 5
    • 0029866466 scopus 로고    scopus 로고
    • Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria
    • Macpherson A, Khoo UY, Forgacs I, Philpott-Howard J, Bjarnason I. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut. 1996;38:365-375-
    • (1996) Gut , vol.38 , pp. 365-375
    • Macpherson, A.1    Khoo, U.Y.2    Forgacs, I.3    Philpott-Howard, J.4    Bjarnason, I.5
  • 6
    • 2442453484 scopus 로고    scopus 로고
    • Therapeutic manipulation of the enteric microflora in inflammatory bowel disease: Antibiotic, probiotics, and prebiotics
    • Sartor B. Therapeutic manipulation of the enteric microflora in inflammatory bowel disease: antibiotic, probiotics, and prebiotics. Gastroenterology. 2004;126:1620-1633.
    • (2004) Gastroenterology , vol.126 , pp. 1620-1633
    • Sartor, B.1
  • 9
    • 22644444207 scopus 로고    scopus 로고
    • Bacterial interaction with cells of the intestinal mucosa: Toll-like receptors and NOD2
    • Cario E. Bacterial interaction with cells of the intestinal mucosa: toll-like receptors and NOD2. Gut. 2005;54:1182-1193.
    • (2005) Gut , vol.54 , pp. 1182-1193
    • Cario, E.1
  • 10
    • 23344431535 scopus 로고    scopus 로고
    • Defects in mucosal immunity leading to Crohn's disease
    • Cobrin GM, Abreu MT. Defects in mucosal immunity leading to Crohn's disease. Immunol Rev. 2005;206:277-295.
    • (2005) Immunol Rev , vol.206 , pp. 277-295
    • Cobrin, G.M.1    Abreu, M.T.2
  • 11
    • 16444362736 scopus 로고    scopus 로고
    • Role of commensal enteric bacteria in the pathogenesis of immune-mediated intestinal inflammation: Lessons from animal models and implications for translational research
    • Sartor RB. Role of commensal enteric bacteria in the pathogenesis of immune-mediated intestinal inflammation: lessons from animal models and implications for translational research. J Pediatr Gastroenterol Nutr. 2005;40(suppl 1):S30-S31.
    • (2005) J Pediatr Gastroenterol Nutr , vol.40 , Issue.SUPPL. 1
    • Sartor, R.B.1
  • 12
    • 34247500287 scopus 로고    scopus 로고
    • High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
    • Kotlowski R, Bernstein CN, Sepehri S, Krause DO. High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease. Gut. 2007;56:669-675.
    • (2007) Gut , vol.56 , pp. 669-675
    • Kotlowski, R.1    Bernstein, C.N.2    Sepehri, S.3    Krause, D.O.4
  • 14
    • 33747050143 scopus 로고    scopus 로고
    • The bacteriology of biopsies differs between newly diagnosed, untreated, Crohn's disease and ulcerative colitis patients
    • Bibiloni R, Mangold M, Madsen KL, Fedorak RN, Tannock GW. The bacteriology of biopsies differs between newly diagnosed, untreated, Crohn's disease and ulcerative colitis patients. J Med Microbiol. 2006;55:1141-1149.
    • (2006) J Med Microbiol , vol.55 , pp. 1141-1149
    • Bibiloni, R.1    Mangold, M.2    Madsen, K.L.3    Fedorak, R.N.4    Tannock, G.W.5
  • 15
    • 0042344991 scopus 로고    scopus 로고
    • Inhibitory effect of probiotic Escherichia coli strain Nissle 1917 on adhesion to and invasion of intestinal epithelial cells by adherent-invasive E. coli strains from isolated patients with Crohn's disease
    • Boudeau J, Glasser AL, Julien S, Colombel JF, Darfeuille-Michaud A. Inhibitory effect of probiotic Escherichia coli strain Nissle 1917 on adhesion to and invasion of intestinal epithelial cells by adherent-invasive E. coli strains from isolated patients with Crohn's disease. Aliment Pharmacol Ther. 2003;18:45-56.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 45-56
    • Boudeau, J.1    Glasser, A.L.2    Julien, S.3    Colombel, J.F.4    Darfeuille-Michaud, A.5
  • 16
    • 0031667561 scopus 로고    scopus 로고
    • Probiotics and dietary fiber: The clinical coming of age of intestinal microecology
    • Floch MH, Moussa K. Probiotics and dietary fiber: the clinical coming of age of intestinal microecology. J Clin Gastroenterol. 1998;27:99-100.
    • (1998) J Clin Gastroenterol , vol.27 , pp. 99-100
    • Floch, M.H.1    Moussa, K.2
  • 17
    • 0025151725 scopus 로고
    • Soluble dietary fiber and short-chain fatty acids: An advance in understanding the human bacterial flora
    • Floch MH. Soluble dietary fiber and short-chain fatty acids: an advance in understanding the human bacterial flora. Am J Gastroenterol. 1990;85:1313-1314.
    • (1990) Am J Gastroenterol , vol.85 , pp. 1313-1314
    • Floch, M.H.1
  • 18
    • 2142810997 scopus 로고    scopus 로고
    • DNA from probiotic bacteria modulates murine and human epithelial and immune function
    • Jijon H, Backer J, Diaz H, Yeung H, Thiel D, et al. DNA from probiotic bacteria modulates murine and human epithelial and immune function. Gastroenterology. 2004;126:1358-1373.
    • (2004) Gastroenterology , vol.126 , pp. 1358-1373
    • Jijon, H.1    Backer, J.2    Diaz, H.3    Yeung, H.4    Thiel, D.5
  • 19
    • 0037185020 scopus 로고    scopus 로고
    • Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells
    • Yan F, Polk DB. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J Biol Chem. 2002;277:50959-50965.
    • (2002) J Biol Chem , vol.277 , pp. 50959-50965
    • Yan, F.1    Polk, D.B.2
  • 20
    • 0032815979 scopus 로고    scopus 로고
    • Impact on the composition of the faecal flora by a new probiotic preparation: Preliminary data on maintenance treatment of patients with ulcerative colitis
    • Venturi A, Gionchetti P, Rizzello F, Johansson R, Zucconi E, et al. Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis. Aliment Pharmacol Ther. 1999;13:1103-1108.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 1103-1108
    • Venturi, A.1    Gionchetti, P.2    Rizzello, F.3    Johansson, R.4    Zucconi, E.5
  • 21
    • 0037309595 scopus 로고    scopus 로고
    • Randomized controlled trial of the effect of Bifidobacteria-fermented milk on ulcerative colitis
    • Ishikawa H, Akedo I, Umesaki Y, Tanaka R, Imaoka A, Otani T. Randomized controlled trial of the effect of Bifidobacteria-fermented milk on ulcerative colitis. J Am Coll Nutr. 2003;22:56-63.
    • (2003) J Am Coll Nutr , vol.22 , pp. 56-63
    • Ishikawa, H.1    Akedo, I.2    Umesaki, Y.3    Tanaka, R.4    Imaoka, A.5    Otani, T.6
  • 23
    • 4644239296 scopus 로고    scopus 로고
    • Maintaining remission of ulcerative colitis with the probiotic Escherichia cols Nissle 1917 is as effective as with standard mesalazine
    • Kruis W, Fric P, Pokrotnieks J, Lukas M, Fixa B, et al. Maintaining remission of ulcerative colitis with the probiotic Escherichia cols Nissle 1917 is as effective as with standard mesalazine. Gut. 2004;53:1617-1623.
    • (2004) Gut , vol.53 , pp. 1617-1623
    • Kruis, W.1    Fric, P.2    Pokrotnieks, J.3    Lukas, M.4    Fixa, B.5
  • 24
    • 0033592203 scopus 로고    scopus 로고
    • Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: A randomized trial
    • Rembacken BJ, Snelling AM, Hawkey PM, Chalmers DM, Axon AT. Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomized trial. Lancet. 1999;354:635-639.
    • (1999) Lancet , vol.354 , pp. 635-639
    • Rembacken, B.J.1    Snelling, A.M.2    Hawkey, P.M.3    Chalmers, D.M.4    Axon, A.T.5
  • 25
  • 26
    • 10644296437 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial assessing the effect of Bifidobacteria-fermented milk on active ulcerative colitis
    • Kato K, Mizuno S, Umesaki Y, Ishii Y, Sugitani M, et al. Randomized placebo-controlled trial assessing the effect of Bifidobacteria-fermented milk on active ulcerative colitis. Aliment Pharmacol Ther. 2004;20:1133-1141.
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 1133-1141
    • Kato, K.1    Mizuno, S.2    Umesaki, Y.3    Ishii, Y.4    Sugitani, M.5
  • 27
    • 0031767090 scopus 로고    scopus 로고
    • Prebiotics and synbiotics: Concepts and nutritional properties
    • Roberfroid M. Prebiotics and synbiotics: concepts and nutritional properties. Br J Nutr. 1998;80:S197-S202.
    • (1998) Br J Nutr , vol.80
    • Roberfroid, M.1
  • 28
    • 12344249654 scopus 로고    scopus 로고
    • Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: A randomized controlled pilot trial
    • Furrie E, Macfarlane S, Kennedy A, Cummings JH, Walsh SV, et al. Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomized controlled pilot trial. Gut. 2005;54:242-249.
    • (2005) Gut , vol.54 , pp. 242-249
    • Furrie, E.1    Macfarlane, S.2    Kennedy, A.3    Cummings, J.H.4    Walsh, S.V.5
  • 29
    • 0027986925 scopus 로고
    • Pouchitis following ileal pouch-anal anastomosis: Definition, pathogenesis and treatment
    • Sandborn WJ. Pouchitis following ileal pouch-anal anastomosis: definition, pathogenesis and treatment. Gastroenterology. 1994;107:1856-1860.
    • (1994) Gastroenterology , vol.107 , pp. 1856-1860
    • Sandborn, W.J.1
  • 31
    • 0033860601 scopus 로고    scopus 로고
    • Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial
    • Gionchetti P, Rizzello F, Venturi A, Brigidi P, Matteuzzi D, et al. Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gastroenterology. 2000;119:305-309.
    • (2000) Gastroenterology , vol.119 , pp. 305-309
    • Gionchetti, P.1    Rizzello, F.2    Venturi, A.3    Brigidi, P.4    Matteuzzi, D.5
  • 32
    • 0024498334 scopus 로고
    • Ileal ecology after pouch-anal anastomosis or ileostomy. A study of mucosal morphology, fecal bacteriology, fecal volatile fatty acids, and their interrelationship
    • Nasmyth DG, Godwin PG, Dixon MF, Williams NS, Johnston D. Ileal ecology after pouch-anal anastomosis or ileostomy. A study of mucosal morphology, fecal bacteriology, fecal volatile fatty acids, and their interrelationship. Gastroenterology. 1989;96:817-824.
    • (1989) Gastroenterology , vol.96 , pp. 817-824
    • Nasmyth, D.G.1    Godwin, P.G.2    Dixon, M.F.3    Williams, N.S.4    Johnston, D.5
  • 33
    • 0026577123 scopus 로고
    • Comparison of triplicated (S) and quadruplicated (W) pelvic ileal reservoirs. Studies on manovolumetry, fecal bacteriology, fecal volatile fatty acids, mucosal morphology and functions results
    • Sagar PM, Holdsworth PJ, Godwin PG, Quirke P, Smith AN, Johnston D. Comparison of triplicated (S) and quadruplicated (W) pelvic ileal reservoirs. Studies on manovolumetry, fecal bacteriology, fecal volatile fatty acids, mucosal morphology and functions results. Gastroenterology. 1992;102:520-528.
    • (1992) Gastroenterology , vol.102 , pp. 520-528
    • Sagar, P.M.1    Holdsworth, P.J.2    Godwin, P.G.3    Quirke, P.4    Smith, A.N.5    Johnston, D.6
  • 35
    • 9144254035 scopus 로고    scopus 로고
    • Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis
    • Mimura T, Rizzello F, Helwig U, Poggioli G, Schreiber S, et al. Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut. 2004;53:108-114.
    • (2004) Gut , vol.53 , pp. 108-114
    • Mimura, T.1    Rizzello, F.2    Helwig, U.3    Poggioli, G.4    Schreiber, S.5
  • 36
    • 0038185270 scopus 로고    scopus 로고
    • Prophylaxis of pouchitis onset with probiotic therapy: A double-blind, placebo-controlled trial
    • Gionchetti P, Rizzello F, Helwig U. Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology. 2003;124:1202-1209.
    • (2003) Gastroenterology , vol.124 , pp. 1202-1209
    • Gionchetti, P.1    Rizzello, F.2    Helwig, U.3
  • 37
    • 2542572614 scopus 로고    scopus 로고
    • Delay of the first onset of pouchitis by oral intake of the probiotic strain Lactobacillus rhamnosus GG
    • Gosselink MP, Schotiten W, van Lieshout L. Delay of the first onset of pouchitis by oral intake of the probiotic strain Lactobacillus rhamnosus GG. Dis Colon Rectum. 2004;47:876-884.
    • (2004) Dis Colon Rectum , vol.47 , pp. 876-884
    • Gosselink, M.P.1    Schotiten, W.2    van Lieshout, L.3
  • 39
    • 12444287916 scopus 로고    scopus 로고
    • Outcomes of four weeks' intervention with probiotics on symptoms and endoscopic appearance after surgical reconstruction with a J-configurated ileal pouch-analanastomosis in ulcerative colitis
    • Laake KO, Bjorneklett A, Aamodt G, Aabakken L, Jacobsen M, et al. Outcomes of four weeks' intervention with probiotics on symptoms and endoscopic appearance after surgical reconstruction with a J-configurated ileal pouch-analanastomosis in ulcerative colitis. Scand J Gastroenterol. 2005;40:43-51.
    • (2005) Scand J Gastroenterol , vol.40 , pp. 43-51
    • Laake, K.O.1    Bjorneklett, A.2    Aamodt, G.3    Aabakken, L.4    Jacobsen, M.5
  • 41
    • 0027502522 scopus 로고
    • Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease wirh special respect to chronic diarrhea - a pilot study
    • Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease wirh special respect to chronic diarrhea - a pilot study. Z Gastroenterol. 1993;31:129-134.
    • (1993) Z Gastroenterol , vol.31 , pp. 129-134
    • Plein, K.1    Hotz, J.2
  • 42
    • 0034828502 scopus 로고    scopus 로고
    • Expression of cytokines, inducible nitric oxide synthase and matrix metalloproteinases in pouchits: Effects of probiotic treatment
    • Ulisse S, Gionchetti P, D'Alo S, Russo FP, Pesce I, et al. Expression of cytokines, inducible nitric oxide synthase and matrix metalloproteinases in pouchits: effects of probiotic treatment. Am J Gastroenterol. 2001;96:2691-2699.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2691-2699
    • Ulisse, S.1    Gionchetti, P.2    D'Alo, S.3    Russo, F.P.4    Pesce, I.5
  • 43
    • 0037843521 scopus 로고    scopus 로고
    • Immunomodulatory consequences of oral administration of Lactobacillus rhamnosus strain GG (L. GG) in healthy volunteers
    • Schultz M, Linde HJ, Lehn N, Zimmermann K, Grossmann J, et al. Immunomodulatory consequences of oral administration of Lactobacillus rhamnosus strain GG (L. GG) in healthy volunteers. J Dairy Res. 2003;70:165-173.
    • (2003) J Dairy Res , vol.70 , pp. 165-173
    • Schultz, M.1    Linde, H.J.2    Lehn, N.3    Zimmermann, K.4    Grossmann, J.5
  • 45
    • 34547655340 scopus 로고    scopus 로고
    • High dose probiotic and prebiotic cotherapy for remission induction of active Crohn's disease
    • Fujimori S, Tatsuguchi A, Gudis K, Kishida T, Mitsui K, et al. High dose probiotic and prebiotic cotherapy for remission induction of active Crohn's disease. J Gastroenterol Hepatol. 2007;22:1199-1204.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1199-1204
    • Fujimori, S.1    Tatsuguchi, A.2    Gudis, K.3    Kishida, T.4    Mitsui, K.5
  • 46
    • 37849015933 scopus 로고    scopus 로고
    • Ecologic niche therapy for Crohn's disease with adjunctive rifaximin antibiotic treatment followed by Flora-Q probiotic maintenance therapy
    • Doman DB, Goldberg HJ, Golding MI. "Ecologic niche" therapy for Crohn's disease with adjunctive rifaximin antibiotic treatment followed by Flora-Q probiotic maintenance therapy. Am J Gastroenterol. 2008;103:251-252.
    • (2008) Am J Gastroenterol , vol.103 , pp. 251-252
    • Doman, D.B.1    Goldberg, H.J.2    Golding, M.I.3
  • 47
    • 0031443860 scopus 로고    scopus 로고
    • Crohn's disease and Escherichia coli. A new approach in therapy to maintain remission of colonic Crohn's disease?
    • Malchow HA. Crohn's disease and Escherichia coli. A new approach in therapy to maintain remission of colonic Crohn's disease? J Clin Gastroenterol 1997;25:653-658.
    • (1997) J Clin Gastroenterol , vol.25 , pp. 653-658
    • Malchow, H.A.1
  • 48
    • 0033870413 scopus 로고    scopus 로고
    • Saccharomyces boulardii in maintenance treatment of Crohn's disease
    • Guslandi M, Mezzi G, Sorghi M, Testoni PA. Saccharomyces boulardii in maintenance treatment of Crohn's disease. Dig Dis Sci. 2000;45:1462-1464.
    • (2000) Dig Dis Sci , vol.45 , pp. 1462-1464
    • Guslandi, M.1    Mezzi, G.2    Sorghi, M.3    Testoni, P.A.4
  • 50
  • 51
    • 0029079279 scopus 로고
    • Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection
    • Rutgeerts P, Hiele M, Geboes K, Peeters M, Penninckx F, et al. Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection. Gastroenterology. 1995;108:1617-1621.
    • (1995) Gastroenterology , vol.108 , pp. 1617-1621
    • Rutgeerts, P.1    Hiele, M.2    Geboes, K.3    Peeters, M.4    Penninckx, F.5
  • 52
    • 20244388832 scopus 로고    scopus 로고
    • Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: A randomized, double-blind, placebo-controlled trial
    • Rutgeerts P, Van Assche G, Vermeire S, D'Haens G, Baert F, et al. Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology. 2005;128:856-861.
    • (2005) Gastroenterology , vol.128 , pp. 856-861
    • Rutgeerts, P.1    Van Assche, G.2    Vermeire, S.3    D'Haens, G.4    Baert, F.5
  • 53
    • 0001528953 scopus 로고    scopus 로고
    • Combination of antibiotic and probiotic treatment is efficacious in prophylaxis of post-operative recurrence of Crohn's disease: A randomized controlled study vs mesalamine
    • Campieri M, Rizzello F, Venturi A, Poggioli G, Ugolini F, et al. Combination of antibiotic and probiotic treatment is efficacious in prophylaxis of post-operative recurrence of Crohn's disease: a randomized controlled study vs mesalamine. Gastroenterology. 2000;118:A781.
    • (2000) Gastroenterology , vol.118
    • Campieri, M.1    Rizzello, F.2    Venturi, A.3    Poggioli, G.4    Ugolini, F.5
  • 54
    • 0036716855 scopus 로고    scopus 로고
    • Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: A randomized controlled trial with Lactobacillus GG
    • Prantera C, Scribano ML, Falasco G, Andreoli A, Luzi C. Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomized controlled trial with Lactobacillus GG. Gut. 2002;51:405-409.
    • (2002) Gut , vol.51 , pp. 405-409
    • Prantera, C.1    Scribano, M.L.2    Falasco, G.3    Andreoli, A.4    Luzi, C.5
  • 55
    • 33646756180 scopus 로고    scopus 로고
    • Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn's disease: A randomised, double blind, placebo controlled GETAID trial
    • Marteau P, Lemann M, Seksik P, Laharie D, Colombel JF, et al. Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn's disease: a randomised, double blind, placebo controlled GETAID trial. Gut. 2006;55:842-847.
    • (2006) Gut , vol.55 , pp. 842-847
    • Marteau, P.1    Lemann, M.2    Seksik, P.3    Laharie, D.4    Colombel, J.F.5
  • 56
    • 34249341111 scopus 로고    scopus 로고
    • Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after Ileo-caecal resection
    • Van Gossum A, Dewit O, Louis E, de Hertogh G, Baert F, et al. Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after Ileo-caecal resection. Inflamm Bowel Dis. 2007;13:135-142.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 135-142
    • Van Gossum, A.1    Dewit, O.2    Louis, E.3    de Hertogh, G.4    Baert, F.5
  • 57
    • 2342434737 scopus 로고    scopus 로고
    • Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis
    • Sheil B, McCarthy J, O'Mahony L, Bennett MW, Ryan P, et al. Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis. Gut. 2004;53:694-700.
    • (2004) Gut , vol.53 , pp. 694-700
    • Sheil, B.1    McCarthy, J.2    O'Mahony, L.3    Bennett, M.W.4    Ryan, P.5
  • 58
    • 36049010630 scopus 로고    scopus 로고
    • Differential immunomodulatory properties of Bifidobacterium logum strains: Relevance to probiotic selection and clinical applications
    • Medina M, Izquierdo E, Ennahar S, Sanz Y. Differential immunomodulatory properties of Bifidobacterium logum strains: relevance to probiotic selection and clinical applications. Clin Exp Immunol. 2007;150:531-538.
    • (2007) Clin Exp Immunol , vol.150 , pp. 531-538
    • Medina, M.1    Izquierdo, E.2    Ennahar, S.3    Sanz, Y.4
  • 59
    • 0038796312 scopus 로고    scopus 로고
    • In situ delivery of therapeutic proteins by recombinant Lactococcus lactis
    • Steidler L, Neirynck S. In situ delivery of therapeutic proteins by recombinant Lactococcus lactis. J Microbiol. 2003;41:63-72.
    • (2003) J Microbiol , vol.41 , pp. 63-72
    • Steidler, L.1    Neirynck, S.2
  • 61
    • 0036709732 scopus 로고    scopus 로고
    • Probiotics and inflammatory bowel disease: From fads and fantasy to facts and future
    • Shanahan F. Probiotics and inflammatory bowel disease: from fads and fantasy to facts and future. Br J Nutr. 2002;88(suppl 1):S5-9.
    • (2002) Br J Nutr , vol.88 , Issue.SUPPL. 1
    • Shanahan, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.