Characterization of the putative type III secretion ATPase CdsN (Cpn0707) of Chlamydophila pneumoniae

Journal of Bacteriology

Volumn 190, Issue 20, 2008, Pages 6580-6588

  Stone, Chris B ^a   Johnson, Dustin L ^a   Bulir, David C ^a   Gilchrist, Jodi D ^a   Mahony, James B ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b ST JOSEPH S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BACTERIAL ENZYME; CDSD ADENOSINE TRIPHOSPHATASE; CDSN ADENOSINE TRIPHOSPHATASE; CDSQ ADENOSINE TRIPHOSPHATASE; CHAPERONE; COPN ADENOSINE TRIPHOSPHATASE; GLUTATHIONE TRANSFERASE; OLIGOMER; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL MEMBRANE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TYPE III SECRETION SYSTEM;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CHLAMYDOPHILA PNEUMONIAE; CLONING, MOLECULAR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; GENE EXPRESSION; KINETICS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PHOSPHORUS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE DELETION;

BACTERIA (MICROORGANISMS); CHLAMYDOPHILA PNEUMONIAE; ESCHERICHIA COLI; NEGIBACTERIA;

EID: 53849145648     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.00761-08     Document Type: Article

References (41)

1. Akeda, Y., and J. Galan. 2005. Chaperone release and unfolding of substrates in type III secretion. Nature 437:911-915.
2. Akeda, Y., and J. Galan. 2004. Genetic analysis of the Salmonella enterica type III secretion-associated ATPase InvC defines discrete functional domains. J. Bacteriol. 186:2402-2412.
3. Andrade, A., J. Pardo, N. Espinosa, G. Perez-Hernandez, and B. Gonzalez-Pedrajo. 2007. Enzymatic characterization of the enteropathogenic Escherichia coli type III secretion ATPase EscN. Arch. Biochem. Biophys. 468:121-127.
4. Betts, H., L. Twiggs, M. Sal, P. Wyrick, and K. Fields. 2008. Bioinformatic and biochemical evidence for the identification of the type III secretion system Needle protein of Chlamydia trachomatis. J. Bacteriol. 190:1680-1690.
5. Blaylock, B., K. Riordan, D. Missiakas, and O. Schneewind. 2006. Characterization of the Yersinia enterocolitica type III secretion ATPase YscN and its regulator, YscL. J. Bacteriol. 188:3525-3534.
6. Carabeo, R., S. Grieshaber, A. Hasenkrug, C. Dooley, and T. Hackstadt. 2004. Requirement for the Rac GTPase in Chlamydia trachomatis invasion of non-phagocytic cells. Traffic 5:418-425.
7. Clifton, D., K. Fields, S. Grieshaber, C. Dooley, E. Fischer, D. Mead, R. Carabeo, and T. Hackstadt. 2004. A chlamydial type III translocated protein is tyrosine-phosphorylated at the site of entry and associated with recruitment of actin. Proc. Natl. Acad. Sci. USA 101:10166-10171.
8. Coombes, B., and J. Mahony. 2002. Identification of MEK- and phosphoinositide-3-kinase-dependant signaling as essential events during Chlamydia pneumoniae invasion of HEp2 cells. Cell. Microbiol. 4:447-460.
9. Cornelis, G. 2006. The type III secretion injectisome. Nat. Rev. Microbiol. 4:811-825.
10. Fields, K., and T. Hackstadt. 2000. Evidence for the secretion of Chlamydia trachomatis CopN by a type III secretion mechanism. Mol. Microbiol. 38:1048-1060.
11. Fields, K., D. Mead, C. Dooley, and T. Hackstadt. 2003. Chlamydia trachomatis type III secretion: evidence for a functional apparatus during earlycycle development. Mol. Microbiol. 48:671-683.
12. Galan, J., and A. Collmer. 1999. Type III secretion machines: bacterial devices for protein delivery into host cells. Science 284:1322-1328.
13. Galan, J., and H. Wolf-Watz. 2006. Protein delivery into eukaryotic cells by type III secretion machines. Nature 444:567-573.
14. Gauthier, A., and B. Finlay. 2003. Translocated intimin receptor and its chaperone interact with ATPase of the type III secretion apparatus of enteropathogenic Escherichia coli. J. Bacteriol. 185:6747-6755.
15. Ghosh, P. 2004. Process of protein transport by the type III secretion system. Microbiol. Mol. Biol. Rev. 68:771-795.
16. Hefty, P., and R. Stephens. 2007. Chlamydial type III secretion system is encoded on ten operons preceded by sigma 70-like promoter elements. J. Bacteriol. 189:198-206.
17. Herrmann, M., A. Schuhmacher, I. Muhldorfer, K. Melchers, C. Prothmann, and S. Dammeier. 2006. Identification and characterization of secreted effector proteins of Chlamydophila pneumoniae TW183. Res. Microbiol. 157:513-524.
18. Hoare, A., P. Timms, P. Bavoil, and D. Wilson. 2008. Spatial constraints within the chlamydial host cell inclusion predict interrupted development and persistence. BMC Microbiol. 8:5.
19. Hsia, R., Y. Pannekoek, E. Ingerowski, and P. Bavoil. 1997. Type III secretion genes identify a putative virulence locus of Chlamydia. Mol. Microbiol. 23:351-359.
20. Hueck, C. 1998. Type III secretion systems in bacterial pathogens of animals and plants. Microbiol. Mol. Biol. Rev. 62:379-433.
21. Hybiske, K., and R. Stephens. 2007. Mechanisms of host cell exit by the intracellular bacterium Chlamydia. Proc. Natl. Acad. Sci. USA 104:11430-11435.
22. Johnson, D., and J. Mahony. 2007. Chlamydophila pneumoniae PknD exhibits dual amino acid specificity and phosphorylates Cpn0712, a putative type III secretion YscD homolog. J. Bacteriol. 189:7549-7555.
23. Johnson, D., C. Stone, and J. Mahony. 2008. Interactions between CdsD, CdsQ, and CdsL, three putative Chlamydophila pneumoniae type III secretion proteins. J. Bacteriol. 190:2972-2980.
24. Journet, L., C. Agrain, P. Broz, and G. Cornelis. 2003. The needle length of bacterial injectisomes is determined by a molecular ruler. Science 302:1757-1760.
25. Karimova, G., N. Dautin, and D. Ladant. 2005. Interaction network among Escherichia coli membrane proteins involved in cell division as revealed by bacterial two-hybrid analysis. J. Bacteriol. 187:2233-2243.
26. Lane, B., C. Mutchler, S. Khodor, S. Grieshaber, and R. Carabeo. 2008. Chlamydial entry involves TARP binding of guanine nucleotide exchange factors. PLoS Pathog. 4:1-11.
27. Lugert, R., M. Kuhns, T. Polch, and U. Gross. 2004. Expression and localization of type III secretion-related proteins of Chlamydia pneumoniae. Med. Microbiol. Immunol. 193:163-171.
28. Minamino, T., and M. Macnab. 2000. FliH, a soluble component of the type III flagellar export apparatus of Salmonella, forms a complex with FliI and inhibits ATPase activity. Mol. Microbiol. 37:1494-1503.
29. Moulder, J. 1991. Interaction of chlamydiae and host cells in vitro. Microbiol. Rev. 55:143-190.
30. Muller, S., C. Pozidis, R. Stone, C. Meesters, M. Chami, A. Engel, A. Economou, and H. Stahlberg. 2006. Double hexameric ring assembly of the type III protein translocase ATPase HrcN. Mol. Microbiol. 61:119-125.
31. Pallen, M., C. Bailey, and S. Beatson. 2006. Evolutionary links between FliH/YscL-like proteins from bacterial type III secretion systems and second-stalk components of the F0F1 and vacuolar ATPases. Protein Sci. 15:935-940.
32. Peters, J., J. Wilson, G. Myers, P. Timms, and P. Bavoil. 2007. Type III secretion a la Chlamydia. Trends Microbiol. 15:241-251.
33. Pozidis, C., A. Chalkiadaki, A. Gomez-Serrano, H. Stahlberg, I. Brown, A. Tampakaki, et al. 2003. Type III protein translocase: HrcN is a peripheral ATPase that is activated by oligomerization. J. Biol. Chem. 278:25816-25824.
34. Scidmore, M., and T. Hackstadt. 2001. Mammalian 14-3-3beta associates with the Chlamydia trachomatis inclusion membrane via its interaction with IncG. Mol. Microbiol. 39:1638-1650.
35. Sorg, J., B. Blaylock, and O. Schneewind. 2006. Secretion signal recognition by YscN, the Yersinia type III secretion ATPase. Proc. Natl. Acad. Sci. USA 103:16490-16495.
36. Stephens, R., S. Kalman, C. Lammel, J. Fan, R. Marathe, L. Aravind, W. Mitchell, L. Olinger, R. Tatusov, Q. Zhao, E. Koonin, and R. Davis. 1998. Genome sequencing of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science 282:754-759.
37. Su, H., F. McClarty, G. Dong, Z. Hatch, K. Pan, and G. Zhong. 2004. Activation of Raf/Mek/Erk/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids. J. Biol. Chem. 279:9409-9416.
38. Subtil, A., B. Wyplosz, M. Balana, and A. Dautry-Varsat. 2004. Analysis of Chlamydia caviae entry sites and involvement of Cdc42 and Rac activity. J. Cell Sci. 117:3923-3933.
39. Thomas, J., G. Stafford, and C. Hughes. 2004. Docking of cytosolic chaperone-substrate complexes at the membrane ATPase during flagellar type III protein export. Proc. Natl. Acad. Sci. USA 101:3945-3950.
40. Woestyn, S., A. Allaoui, P. Wattiau, and G. Cornelis. 1994. YscN, the putative energizer of the Yersinia Yop secretion machinery. J. Bacteriol. 176:1561-1569.
41. Zarivach, R., M. Vuckovic, W. Deng, B. Finlay, and N. Strynadka. 2007. Structural analysis of a prototypical ATPase from the type III secretion system. Nat. Struct. Mol. Biol. 14:131-137.