Models and mechanisms of energy balance regulation in the young

Proceedings of the Nutrition Society

Volumn 67, Issue 4, 2008, Pages 327-333

  Mercer, Julian G ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Developmental origins; Diet; Diet induced obesity; Obesity

Indexed keywords

AGOUTI RELATED PROTEIN; AMPHETAMINE; COCAINE; DRUG VEHICLE; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN 4 RECEPTOR; NEUROPEPTIDE Y;

ANIMAL CELL; BODY COMPOSITION; BODY WEIGHT; CHILD NUTRITION; CONFERENCE PAPER; DIETARY INTAKE; DISEASE MODEL; ENERGY BALANCE; ENVIRONMENTAL FACTOR; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; HYPOTHALAMUS; MACRONUTRIENT; MOUSE; NEUROANATOMY; NONHUMAN; OBESITY; PHENOTYPE; PRENATAL DEVELOPMENT; RAT; REGULATORY MECHANISM; UNITED KINGDOM;

ADOLESCENT; AGE FACTORS; ANIMALS; BODY COMPOSITION; BODY WEIGHT; CHILD; ENERGY INTAKE; ENERGY METABOLISM; HUMANS; OBESITY; OVERWEIGHT;

ANIMALIA; RODENTIA;

EID: 53849141187     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665108008628     Document Type: Conference Paper

References (43)

1. Department of Health and Human Services, Centers for Disease Control and Prevention (2007) US obesity trends 1985-2006. http://www.cdc.gov/nccdphp/dnpa/ obesity/trend/maps/
2. International Obesity TaskForce (2007) Increasing obesity rates in Europe 1985-2005. http://www.iotf.org/database/TrendsEuropeanadultsthroughtimev3.htm
3. World Health Organization Europe (2007) Fact sheet no. 2.3: Prevalence of excess body weight and obesity in children and adolescents. http://www.euro.who.int/Document/EHI/ENHIS_Factsheet_2_3.pdf
4. Berthoud H-R (2002) Multiple neural systems controlling food intake and bodyweight. Neurosci Biobehav Rev 26, 393-428.
5. Friedman JM & Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395, 763-770.
6. Saper CB, Chou TC & Elmquist JK (2002) The need to feed: homeostatic and hedonic control of eating. Neuron 36, 199-211.
7. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ & Baskin DG (2000) Central nervous system control of food intake. Nature 404, 661-671.
8. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT & Trayhurn P (1996) Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Letters 387, 113-116.
9. Mercer JG, Moar KM, Rayner DV, Trayhurn P & Hoggard N (1997) Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice. FEBS Letters 402, 185-188.
10. Stellar E (1954) The physiology of motivation. Psychol Rev 61, 5-22.
11. Hahn TM, Breininger JF, Baskin DG & Schwartz MW (1998) Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci 1, 271-272.
12. Elias CF, Lee C, Kelly J, Aschkenasi C, Ahimaa RS, Couceyro PR, Kuhar MJ, Saper CB & Elmquist JK (1998) Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21, 1375-1385.
13. Hebebrand J, Friedel S, Schauble N, Geller F & Hinney A (2003) Perspectives: molecular genetic research in human obesity. Obes Rev 4, 139-146.
14. Zhang YY, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM (1994) Positional cloning of the mouse obese gene and its human homolog. Nature 372, 425-432.
15. Montague CT, Farooqi IS, Whitehead JP et al. (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903-908.
16. Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA & O'Rahilly S (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 341, 879-884.
17. Farouqi IS & O'Rahilly S (2006) Genetics of obesity in humans. Endocr Rev 27, 710-718.
18. Tartaglia LA, Dembski M, Weng X et al. (1995) Identification and expression cloning of a leptin receptor Ob-R. Cell 83, 1263-1271.
19. Clement K, Vaisse C, Lahlou N et al. (1998) Mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398-401.
20. Krude H, Biebermann H, Luck W, Horn R, Brabant G & Gruters A (1998) Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19, 155-157.
21. Balthasar N (2006) Genetic dissection of neuronal pathways controlling energy homeostasis. Obesity 14, 222S-227S.
22. Swinburn B, Egger G & Raza F (1999) Dissecting obesogenic environments: The development and application of a framework for identifying and prioritising environmental interventions for obesity. Prev Med 29, 563-570.
23. Poston WSC II & Foreyt JP (1999) Obesity is an environmental issue. Atherosclerosis 146, 201-209.
24. Buettner R, Scholmerich J & Bollheimer LC (2007) High-fat diets: Modeling the metabolic disorders of human obesity in rodents. Obesity 15, 798-808.
25. Mercer JG & Archer ZA (2008) Putting the diet back into diet-induced obesity: diet-induced hypothalamic gene expression. Eur J Pharmacol (In the Press).
26. Archer ZA, Rayner DV & Mercer JG (2004) Hypothalamic gene expression is altered in underweight but obese juvenile male Sprague-Dawley rats fed a high energy diet. J Nutr 134, 1369-1374.
27. Archer ZA, Courneloup D, Rayner DV, Barrett P, Moar KM & Mercer JG (2007) Solid and liquid obesogenic diets induce obesity and counter-regulatory changes in hypothalamic gene expression in juvenile Sprague-Dawley rats. J Nutr 137, 1483-1490.
28. Ainslie DA, Proietto J, Fam BC & Thorburn AW (2000) Short-term, high-fat diets lower circulating leptin concentrations in rats. Am J Clin Nutr 71, 438-442.
29. Archer ZA & Mercer JG (2007) Brain responses to obesogenic diets and diet-induced obesity. Proc Nutr Soc 66, 124-130.
30. Archer ZA, Rayner DV, Barrett P, Balik A, Duncan JS, Moar KM & Mercer JG (2005) Hypothalamic energy balance gene responses in the Sprague-Dawley rat to supplementation of high-energy diet with liquid Ensure and subsequent transfer to chow. J Neuroendocrinol 17, 711-719.
31. Guan XM, Yu H, Trumbauer M, Frazier E, Van der Ploeg LH & Chen H (1998) Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice. Neuroreport 9, 3415-3419.
32. Lin S, Storlien LH & Huang XF (2000) Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain. Brain Res 875, 89-95.
33. Taylor PD & Poston L (2007) Developmental programming of obesity in mammals. Exp Physiol 92, 287-298.
34. Danielzik S, Langnase K, Mast M, Spethmann C & Muller MJ (2002) Impact of parental BMI on the manifestation of overweight 5-7 year old children. Eur J Nutr 41, 132-138.
35. Grove KL, Grayson BE, Glavas MM, Xiao XQ & Smith MS (2005) Development of metabolic systems. Physiol Behav 86, 646-660.
36. Grove KL, Allen S, Grayson BE & Smith MS (2003) Postnatal development of the hypothalamic neuropeptide Y system. Neuroscience 116, 393-406.
37. Ahima RS, Prabakaran D & Flier JS (1998) Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. J Clin Invest 101, 1020-1027.
38. Bouret SG, Draper SJ & Simerly RB (2004) Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304, 108-110.
39. McMillen C, Adam CL & Muhlhausler BS (2005) Early origins of obesity: programming the appetite regulatory system. J Physiol 565, 9-17.
40. Plagemann A (2005) Perinatal programming and functional teratogenesis: Impact on body weight regulation and obesity. Physiol Behav 86, 661-668.
41. Gallou-Kabani C, Vige A, Gross M-S, Boileau C, Rabes J-P, Fruchart-Najib J, Jais J-P & Junien C (2007) Resistance to high-fat diet in the female progeny of obese mice fed a control diet during the periconceptual, gestation, and lactation periods. Am J Physiol Endocrinol Metab 292, E1095-E1100.
42. Shankar K, Harrell A, Liu X, Gilchrist JM, Ronis MJJ & Badger TM (2008) Maternal obesity at conception programs obesity in the offspring. Am J Physiol Regul Integr Comp Physiol 294, R528-R538.
43. Kozak R, Richy S & Beck B (2005) Persistent alterations in neuropeptide Y release in the paraventricular nucleus of rats subjected to dietary manipulation during early life. Eur J Neurosci 21, 2887-2892.