Testosterone has potent, selective effects on the morphology of pelvic autonomic neurons which control the bladder, lower bowel and internal reproductive organs of the male rat

Neuroscience

Volumn 85, Issue 2, 1998, Pages 543-556

  Keast, J R ^a   Saunders, R J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Androgen receptors; Autonomic nervous system; Parasympathetic; Pelvic ganglia; Puberty; Sympathetic

Indexed keywords

ANDROGEN; TESTOSTERONE;

ADRENERGIC SYSTEM; ARTICLE; AUTONOMIC INNERVATION; CASTRATION; CHOLINERGIC SYSTEM; HORMONE SUBSTITUTION; NERVE CELL; NERVE CONDUCTION; PRIORITY JOURNAL; PUBERTY; TESTOSTERONE RELEASE;

AGING; ANIMALS; AUTONOMIC NERVOUS SYSTEM; CHOLINERGIC FIBERS; COLON; GENITALIA, MALE; MALE; NEURONS, AFFERENT; NEUROPEPTIDE Y; NOREPINEPHRINE; ORCHIECTOMY; PELVIS; RATS; RATS, WISTAR; TESTOSTERONE; URINARY BLADDER; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0032495865     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00631-3     Document Type: Article

References (51)

1. Anderson G. F., Navarro S. P. The response of autonomic receptors to castration and testosterone in the urinary bladder of the rabbit. J. Urol. 140:1988;885-889.
2. Arnold A. P., Gorski R. A. Gonadal steroid induction of structural sex differences in the central nervous system. A. Rev. Neurosci. 7:1984;413-442.
3. Breedlove S. M. Sexual dimorphism in the vertebrate nervous system. J. Neurosci. 12:1992;4133-4142.
4. Bustamante D., Lara H., Belmar J. Changes of norepinephrine levels, tyrosine hydroxylase and dopamine-beta-hydroxylase activities after castration and testosterone treatment in vas deferens of adult rats. Biol. Reprod. 40:1989;541-548.
5. Chamness S. L., Ricker D. D., Crone J. K., Dembeck C. L., Maguire M. P., Burnett A. L., Chang T. S. K. The effect of androgen on nitric oxide synthase in the male reproductive tract of the rat. Fert. Steril. 63:1995;1101-1107.
6. Dail W. G. (1993) Autonomic innervation of male genitalia. In Nervous Control of the Urogenital System (ed. Maggi C. A.), pp. 69-102. Harwood Academic Publishers, Chur, Switzerland.
7. Dail W. G., Evan A. P., Eason H. R. The major ganglion in the pelvic plexus of the male rat: a histochemical and ultrastructural study. Cell Tiss. Res. 159:1975;49-62.
8. Dail W. G., Moll M. A., Weber K. Localization of vasoactive intestinal polypeptide in penile erectile tissue and in the major pelvic ganglion of the rat. Neuroscience. 10:1983;1379-1386.
9. Eika B., Levin R. M., Longhurst P. A. Modulation of urinary bladder function by sex hormones in streptozotocin-diabetic rats. J. Urol. 152:1994;537-543.
10. Freeman L. M., Breedlove S. M. Motoneurons innervating guinea pig perineal muscles are sexually dimorphic in size but not number. Brain Res. 690:1995;1-7.
11. Freeman L. M., Padgett B. A., Prins G. S., Breedlove S. M. Distribution of androgen receptor immunoreactivitiy in the spinal cord of wild-type, androgen-insensitive and gonadectomized male rats. J. Neurobiol. 27:1994;51-59.
12. Garban H., Marquez D., Cai L., Rajfer J., Gonzalez-Cadavid N. F. Restoration of normal adult penile erectile response in aged rats by long-term treatment with androgens. Biol. Reprod. 53:1995;1365-1372.
13. García-Segura L. M., Chowen J. A., Párducz A., Naftolin N. Gonadal hormones as promoters of structural synaptic plasticity: cellular mechanisms. Prog. Neurobiol. 44:1994;279-307.
14. Giuliano F., Rampin O., Schirar A., Jardin A., Rousseau J.-P. Autonomic control of penile erection: modulation by testosterone in the rat. J. Neuroendocrinol. 5:1993;677-683.
15. Greenwood D., Coggeshall R. E., Hulsebosch C. E. Sexual dimorphism in the numbers of neurons in the pelvic ganglia of adult rats. Brain Res. 340:1985;160-162.
16. Hamill R. W., Earley C. J., Guernsey L. A. Hormonal regulation of adult sympathetic neurons: the effects of castration on tyrosine hydroxylase activity. Brain Res. 299:1984;331-337.
17. Hamill R. W., Guernsey L. A. Hormonal regulation of sympathetic neuron development: the effects of neonatal castration. Devl Brain Res. 11:1983;303-307.
18. Hamill R. W., Schroeder B. Hormonal regulation of adult sympathetic neurons: the effects of castration on neuropeptide Y, norepinephrine, and tyrosine hydroxylase activity. J. Neurobiol. 21:1990;731-742.
19. Hart B. J. Testosterone regulation of sexual reflexes in spinal male rats. Science. 155:1967;1283-1284.
20. Heaton J. P. W., Varrin S. J. Effects of castration and exogenous testosterone supplementation in an animal model of penile erection. J. Urol. 151:1994;797-800.
21. Holmquist F., Persson K., Bødker A., Andersson K.-E. Some pre- and postjunctional effects of castration in rabbit isolated corpus cavernosum and urethra. J. Urol. 152:1994;1011-1016.
22. Iqbal J., Swanson J. J., Prins G. S., Jacobson C. D. Androgen receptor-like immunoreactivity in the Brazilian opossum brain and pituitary: distribution and effects of castration and testosterone replacement in the adult male. Brain Res. 703:1995;1-18.
23. Kawata M. Roles of steroid hormones and their receptors in structural organization in the nervous system. Neurosci. Res. 24:1995;1-46.
24. Keast J. R. Patterns of co-existence of peptides and differences of nerve fibre types associated with noradrenergic and non-noradrenergic (putative cholinergic) neurons in the major pelvic ganglion of the male rat. Cell Tiss. Res. 266:1991;405-415.
25. Keast J. R. Location and peptide content of pelvic neurons supplying the muscle and lamina propria of the rat vas deferens. J. auton. nerv. Syst. 40:1992;1-12.
26. Keast J. R. Neuropeptide-containing axon terminals in the male rat major pelvic ganglion are primarily of sacral origin. J. auton. nerv. Syst. 47:1994;151-158.
27. Keast J. R. Visualization and immunohistochemical characterization of sympathetic and parasympathetic neurons in the male rat major pelvic ganglion. Neuroscience. 66:1995;655-662.
28. Keast J. R., Booth A. M., de Groat W. C. Distribution of neurons in the major pelvic ganglion of the rat which supply the bladder, colon or penis. Cell Tiss. Res. 256:1989;105-112.
29. Keast J. R., de Groat W. C. Immunohistochemical characterization of pelvic neurons which project to the bladder, colon, or penis in rats. J. comp. Neurol. 288:1989;387-400.
30. Keast J. R., Furness J. B., Costa M. Origins of peptide and norepinephrine nerves in the mucosa of the guinea-pig small intestine. Gastroenterology. 86:1984;637-644.
31. Keast J. R., Luckensmeyer G. B., Schemann M. All pelvic neurons in male rats contain synthetic enzymes for either noradrenaline or acetylcholine. Neurosci. Lett. 196:1995;209-212.
32. Kepper M., Keast J. R. Location, immunohistochemical properties and spinal connections of pelvic autonomic neurons which innervate the rat prostate gland. Cell Tiss. Res. 281:1995;533-542.
33. Kolbeck S. C., Steers W. D. Origin of neurons supplying the vas deferens of the rat. J. Urol. 149:1993;918-921.
34. Lin A. T.-L., Chen M.-T., Chiang C. H., Yange C.-H., Chang L. S. Effect of orchiectomy on the alpha adrenergic contractile response of dog prostate. J. Urol. 154:1995;1930-1933.
35. Luckensmeyer G. B., Keast J. R. Projections from the prevertebral and major pelvic ganglia to the ileum and large intestine of the rat. J. auton. nerv. Syst. 49:1994;247-259.
36. Luckensmeyer G. B., Keast J. R. Immunohistochemical characterisation of sympathetic and parasympathetic pelvic neurons which project to the large intestine in the male rat. Cell Tiss. Res. 281:1995;551-559.
37. Melvin J. E., Hamill R. W. The major pelvic ganglion: androgen control of postnatal development. J. Neurosci. 7:1987;1607-1612.
38. Melvin J. E., Hamill R. W. Hypogastric ganglion perinatal development: evidence for androgen specificity via androgen receptors. Brain Res. 485:1989;11-19.
39. Melvin J. E., McNeill T. H., Hamill R. W. Biochemical and morphological effects of castration on the postorganizational development of the hypogastric ganglion. Devl Brain Res. 38:1988;131-139.
40. Melvin J. E., McNeill T. H., Hervonen A., Hamill R. W. Organizational role of testosterone on the biochemical and morphological development of the hypogastric ganglion. Brain Res. 485:1989;1-10.
41. Mills T. M., Wiedmeier V. T., Stopper V. S. Androgen maintenance of erectile function in the rat penis. Biol. Reprod. 46:1992;342-348.
42. Morita T., Tsuchiya N., Tsujii T., Kondo S. Changes of autonomic receptors following castration and estrogen administration in the male rabbit urethral smooth muscle. Tohoku J. exp. Med. 166:1992;403-405.
43. Papka R. E., Srinivasan B., Miller K. E., Hayashi S. Localization of estrogen receptor protein and estrogen receptor messenger RNA in peripheral autonomic and sensory neurons. Neuroscience. 79:1997;1153-1163.
44. Penson D. F., Ng C., Cai L., Rajfer J., González-Cadavid N. F. Androgen and pituitary control of penile nitric oxide synthase and erectile function in the rat. Biol. Reprod. 55:1996;567-574.
45. Prins G. S., Birch L., Greene G. L. Androgen receptor localization in different cell types of the adult rat prostate. Endocrinology. 129:1991;3187-3199.
46. Purinton P. T., Fletcher T. F., Bradley W. E. Gross and light microscopic features of the pelvic plexus in the rat. Anat. Rec. 175:1973;697-706.
47. Schroder F. H. Endocrine therapy: where do we stand and where are we going? Cancer Surv. 11:1991;177-194.
48. Sjöstrand N. O., Swedin G. Influence of age, growth, castration and testosterone treatment on the noradrenaline levels of the ductus deferens and the auxiliary male reproductive glands in the rat. Acta physiol. scand. 98:1976;323-338.
49. Smith G. T. Use of PG-21 immunocytochemistry to detect androgen receptors in the songbird brain. J. Histochem. Cytochem. 44:1996;1075-1080.
50. Tabatabai M., Booth A. M., de Groat W. C. Morphological and electrophysiological properties of pelvic ganglion cells in the rat. Brain Res. 382:1986;61-70.
51. Takeda H., Chodak G., Mutchnik S., Nakamoto T., Chang C. Immunohistochemical localization of androgen receptors with mono- and polyclonal antibodies to androgen receptor. J. Endocrinol. 126:1990;1-25.