Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells

British Journal of Cancer

Volumn 99, Issue 8, 2008, Pages 1246-1250

  Treeck, O ^a   Lattrich, C ^a   Juhasz Boess, I ^a   Buchholz, S ^a   Pfeiler, G ^a   Ortmann, O ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Adiponectin; Breast cancer cell line; Gene regulation; Mammary epithelial cell

Indexed keywords

ADIPONECTIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; INTERLEUKIN 1BETA CONVERTING ENZYME;

ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

ADIPONECTIN; BREAST NEOPLASMS; CELL LINE; CELL PROLIFERATION; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; MAMMARY GLANDS, HUMAN; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 53849120899     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604692     Document Type: Article

References (29)

1. Abbasi F, Chu J, Lamendola C, McLaughlin T, Hayden J, Reaven G, Reaven P (2004) Discrimination Between Obesity and Insulin Resistance in the Relationship With Adiponectin. Diabetes 53: 585-590
2. Arditi JD, Venihaki M, Karalis KP, Chrousos GP (2007) Antiproliferative effect of adiponectin on MCF7 breast cancer cells: a potential hormonal link between obesity and cancer. Horm Metab Res 39: 9-13
3. Brakenhielm E, Veitonmaki N, Cao R, Kihara S, Matsuzawa Y, Zhivotovsky B, Funahashi T, Cao Y (2004) Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci USA 101: 2476-2481
4. Deng S, Zhou H, Xiong R, Lu Y, Yan D, Xing T, Dong L, Tang E, Yang H (2007) Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics. Breast Cancer Res Treat 104: 21-30
5. Dieudonne MN, Bussiere M, Dos Santos E, Leneveu MC, Giudicelli Y, Pecquery R (2006) Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. Biochem Biophys Res Commun 345: 271-279
6. Fujiwara T, Saito A, Suzuki M, Shinomiya H, Suzuki T, Takahashi E, Tanigami A, Ichiyama A, Chung CH, Nakamura Y, Tanaka K (1998) Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease. Genomics 54: 155-158
7. Grossmann ME, Nkhata KJ, Mizuno NK, Ray A, Cleary MP (2008) Effects of adiponectin on breast cancer cell growth and signaling. Br J Cancer 98: 370-379
8. Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (2002) Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor. J Biol Chem 277: 33571-33579
9. Kang JH, Lee YY, Yu BY, Yang BS, Cho KH, Yoon DK, Roh YK (2005) Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell. Arch Pharm Res 28: 1263-1269
10. Kang JH, Yu BY, Youn DS (2007) Relationship of serum adiponectin and resistin levels with breast cancer risk. J Korean Med Sci 22: 117-121
11. Lee CH, Wei LN (2000) Characterization of the mouse nuclear orphan receptor TR2-11 gene promoter and its potential role in retinoic acid-induced P19 apoptosis. Biochem Pharmacol 60: 127-136
12. Leygue E, Dotzlaw H, Watson PH, Murphy LC (1998) Altered estrogen receptor alpha and beta messenger RNA expression during human breast tumorigenesis. Cancer Res 58: 3197-3201
13. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408
14. Mantzoros C, Petridou E, Dessypris N, Chavelas C, Dalamaga M, Alexe D, Papadiamantis Y, Markopoulos C, Spanos E, Chrousos G, Trichopoulos D (2004) Adiponectin and breast cancer risk. J Clin Endocrinol Metab 89: 1102-1107
15. Matsuzawa Y, Funahashi T, Nakamura T (1999) Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann N Y Acad Sci 892: 146-154
16. Miyoshi Y, Funahashi T, Kihara S, Taguchi T, Tamaki Y, Matsuzawa Y, Noguchi S (2003) Association of serum adiponectin levels with breast cancer risk. Clin Cancer Res 9: 5699-5704
17. Nakayama S, Miyoshi Y, Ishihara H, Noguchi S (2007) Growth-inhibitory effect of adiponectin via adiponectin receptor 1 on human breast cancer cells through inhibition of S-phase entry without inducing apoptosis. Breast Cancer Res Treat [Epub ahead of print]
18. Neumeier M, Weigert J, Schaffler A, Wehrwein G, Muller-Ladner U, Scholmerich J, Wrede C, Buechler C (2006) Different effects of adiponectin isoforms in human monocytic cells. J Leukoc Biol 79: 803-808
19. Park SW, Hu X, Gupta P, Lin YP, Ha SG, Wei LN (2007) SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. Nat Struct Mol Biol 14: 68-75
20. Peng B, Lu B, Leygue E, Murphy LC (2003) Putative functional characteristics of human estrogen receptor-beta isoforms. J Mol Endocrinol 30: 13-29
21. Pfeiler GH, Buechler C, Neumeier M, Schäffler A, Schmitz G, Ortmann O, Treeck O (2008) Adiponectin effects on human breast cancer cells are dependent on 17-beta estradiol. Oncol Rep 19: 787-793
22. Roger P, Sahla ME, Makela S, Gustafsson JA, Baldet P, Rochefort H (2001) Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors. Cancer Res 61: 2537-2541
23. Shaw JA, Udokang K, Mosquera JM, Chauhan H, Jones JL, Walker RA (2002) Oestrogen receptors alpha and beta differ in normal human breast and breast carcinomas. J Pathol 198: 450-457
24. Skliris GP, Munot K, Bell SM, Carder PJ, Lane S, Horgan K, Lansdown MR, Parkes AT, Hanby AM, Markham AF, Speirs V (2003) Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model. J Pathol 201: 213-220
25. Speirs V, Adams IP, Walton DS, Atkin SL (2000) Identification of wild-type and exon 5 deletion variants of estrogen receptor beta in normal human mammary gland. J Clin Endocrinol Metab 85: 1601-1605
26. Speirs V, Skliris GP, Burdall SE, Carder PJ (2002) Distinct expression patterns of ER alpha and ER beta in normal human mammary gland. J Clin Pathol 55: 371-374
27. Stahlberg A, Aman P, Ridell B, Mostad P, Kubista M (2003) Quantitative real-time PCR method for detection of B-lymphocyte monoclonality by comparison of kappa and lambda immunoglobulin light chain expression. Clin Chem 49: 51-59
28. Takahata C, Miyoshi Y, Irahara N, Taguchi T, Tamaki Y, Noguchi S (2007) Demonstration of adiponectin receptors 1 and 2 mRNA expression in human breast cancer cells. Cancer Lett 250: 229-236
29. Treeck O, Juhasz-Boess I, Lattrich C, Horn F, Goerse R, Ortmann O (2008) Effects of exon-deleted estrogen receptor beta transcript variants on growth, apoptosis and gene expression of human breast cancer cell lines. Breast Cancer Res Treat 110: 507-520