High-titer antichromatin antibody is associated with proliferative class IV of lupus nephritis

Clinical Rheumatology

Volumn 27, Issue 11, 2008, Pages 1417-1421

  Carvalho, J F ^a   Viana, V S T ^a   Borba, E F ^a   do Nascimento, A P ^a   Leon, E P ^a   Testagrossa, L A ^a   Barros, R T ^a   Bonfa E ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anti ds DNA; Antichromatin antibody; Antinucleosome antibody; Autoantibody; Lupus nephritis; Systemic lupus erythematosus

Indexed keywords

ALBUMIN; AUTOANTIBODY; BIOLOGICAL MARKER; CHROMATIN ANTIBODY; CREATININE; DOUBLE STRANDED DNA ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGE; ANTIBODY TITER; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FROZEN SECTION; HISTOPATHOLOGY; HUMAN; IMMUNOFLUORESCENCE; KIDNEY BIOPSY; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NEPHRITIS; PRIORITY JOURNAL; PROTEINURIA; SEX RATIO; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; ANTIBODIES, ANTINUCLEAR; BIOLOGICAL MARKERS; COHORT STUDIES; FEMALE; HUMANS; KIDNEY; KIDNEY FUNCTION TESTS; LUPUS NEPHRITIS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 53849120199     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-008-0939-4     Document Type: Article

References (30)

1. Kotzin BL (1996) Systemic lupus erythematosus. Cell 85:303-306
2. Koffler D, Schur PH, Kunkel HG (1967) Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med 126:607-624
3. Tan EM (1989) Antinuclear antibodies: Diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 44:93-151
4. Koffler D, Carr R, Agnello V, Thoburn R, Kunkel HG (1971) Antibodies to polynucleotides in human sera: Antigenic specificity and relation to disease. J Exp Med 134:294-312
5. Foster MH, Cizman B, Madaio MP (1993) Nephritogenic autoantibodies in systemic lupus erythematosus: Immunochemical properties, mechanisms of immune deposition, and genetic origins. Lab Invest 69:494-507
6. Reichlin M, Wolfson-Reichlin M (2003) Correlations of anti-dsDNA and anti-ribosomal P autoantibodies with lupus nephritis. Clin Immunol 108:69-72
7. Uwatoko S, Mannik M (1988) Low-molecular weight C1q-binding immunoglobulin G in patients with systemic lupus erythematosus consists of autoantibodies to the collagen-like region of C1q. J Clin Invest 82:816-824
8. Renaudineau Y, Croquefer S, Jousse S, Renaudineau E et al (2006) Association of alpha-actinin-binding anti-double-stranded DNA antibodies with lupus nephritis. Arthritis Rheum 54:2523-2532
9. Cervera R, Viñas O, Ramos-Casals M, Font J et al (2003) Anti-chromatin antibodies in systemic lupus erythematosus: A useful marker for lupus nephropathy. Ann Rheum Dis 62:431-434
10. Kalaaji M, Fenton KA, Mortensen ES, Olsen R et al (2007) Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis. Kidney Int 71:664-672
11. Sigal L (2007) Basic science for the clinician 42: Handling the corpses: apoptosis, necrosis, nucleosomes and (quite possibly) the immunopathogenesis of SLE. J Clin Rheumatol 13:44-48
12. Burlingame RW, Cervera R (2002) Anti-chromatin (anti-nucleosome) autoantibodies. Autoimmun Rev 1:321-328
13. Amoura Z, Koutouzov A, Chabre H, Cacoub P et al (2000) Presence of antinucleosome antibodies in a restricted set of connective tissue diseases. Arthritis Rheum 43:76-84
14. Min DJ, Kim SJ, Park SH, Seo YI et al (2002) Antinucleosome antibody: significance in lupus patients lacking anti-double-stranded DNA antibody. Clin Exp Rheumatol 20:13-18
15. Amoura Z, Chabre H, Koutouzov S, Lotton C et al (1994) Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria. Arthritis Rheum 37:1684-1688
16. Ng KP, Manson JJ, Rahman A, Isenberg DA (2006) Association of antinucleosome antibodies with disease flare in serologically active clinically quiescent patients with systemic lupus erythematosus. Arthritis Rheum 55:900-904
17. do Nascimento AP, Viana VST, Testagrossa LA, Leon EP et al (2006) Antibodies to ribosomal P proteins: A potential serologic marker for lupus membranous glomerulonephritis. Arthritis Rheum 54:1568-1572
18. Waldman M, Madaio MP (2005) Pathogenic autoantibodies in lupus nephritis. Lupus 14:19-24
19. Ravirajan CT, Rowse L, Macgowan JR, Isenberg DA (2001) An analysis of clinical disease activity and nephritis-associated serum autoantibody profiles in patients with systemic lupus erythematosus: A cross-sectional study. Rheumatology 40:1405-1412
20. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725
21. Weening JJ, D'Agati VD, Schwartz MM, Seshan SV et al (2004) The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int 65:521-530
22. Bombardier C, Gladman DD, Urowitz MB, Caron D et al (1992) Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35:630-640
23. Aarden LA, de Groot ER, Feltkamp TE (1975) Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique. Ann N Y Acad Sci 254:505-515
24. Mannik M, Merrill CE, Stamps LD, Wener MH (2003) Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus. J Rheumatol 30:1495-1504
25. Amoura Z, Piette JC, Bach JF, Koutouzov S (1999) The key role of nucleosomes in lupus. Arthritis Rheum 42:833-843
26. Tikly M, Gould T, Wadee AA, van der Westhuizen E, Mokgethwa BB (2007) Clinical and serological correlates of antinucleosome antibodies in South Africans with systemic lupus erythematosus. Clin Rheumatol 26:2121-2125
27. Saisoong S, Eiam-Ong S, Hanvivatvong O (2006) Correlations between antinucleosome antibodies and anti-double-stranded DNA antibodies, C3, C4, and clinical activity in lupus patients. Clin Exp Rheumatol 24:51-58
28. Grootscholten C, van Bruggen MC, van der Pijl JW, de Jong EM et al (2003) Deposition of nucleosomal antigens (histones and DNA) in the epidermal basement membrane in human lupus nephritis. Arthritis Rheum 48:1355-1362
29. Ghillani-Dalbin P, Amoura Z, Cacoub P, Charuel JL et al (2003) Testing for anti-nucleosome antibodies in daily practice: A monocentric evaluation in 1696 patients. Lupus 12:833-837
30. Stinton LM, Barr SG, Tibbles LA, Yimaz S et al (2007) Autoantibodies in lupus nephritis patients requiring renal transplantation. Lupus 15:394-400