Antibodies to ribosomal P proteins: A potential serologic marker for lupus membranous glomerulonephritis

Arthritis and Rheumatism

Volumn 54, Issue 5, 2006, Pages 1568-1572

  Do Nascimento, Ana Patrícia ^a   Viana, Vilma Dos Santos Trindade ^a   Testagrossa, Leonardo De Abreu ^a   Leon, Elaine Pires ^a   Borba, Eduardo Ferreira ^a   Barros, Rui Toledo ^a   Bonfá, Eloísa ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; DOUBLE STRANDED DNA ANTIBODY; PROTEIN ANTIBODY; RIBOSOME PROTEIN P ANTIBODY; UNCLASSIFIED DRUG;

ADULT; ANTIBODY DETECTION; ANTIBODY ISOLATION; ANTIBODY TITER; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DEMOGRAPHY; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; KIDNEY BIOPSY; KIDNEY FUNCTION; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEINURIA; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AUTOANTIBODIES; BIOLOGICAL MARKERS; FEMALE; GLOMERULONEPHRITIS, MEMBRANOUS; HUMANS; LUPUS NEPHRITIS; MALE; RIBOSOMAL PROTEINS;

EID: 33646489304     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.21875     Document Type: Article

References (15)

1. Hulsey M, Goldstein R, Scully L, Surbeck W, Reichlin M. Anti-ribosomal P antibodies in systemic lupus erythematosus: a case-control study correlating hepatic and renal disease. Clin Immunol Immunopathol 1995;74:252-6.
2. Chindalore V, Neas B, Reichlin M. The association between anti-ribosomal P antibodies and active nephritis in systemic lupus erythematosus. Clin Immunol Immunopathol 1998;87:292-6.
3. Martin AL, Reichlin M. Fluctuations of antibody to ribosomal P proteins correlate with appearance and remission of nephritis in SLE. Lupus 1996;5:22-9.
4. Reichlin M, Wolfson-Reichlin M. Evidence for the participation of anti-ribosomal P antibodies in lupus nephritis. Arthritis Rheum 1999;42:2728-9.
5. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus [letter]. Arthritis Rheum 1997;40:1725.
6. Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int 2004;65:521-30.
7. Magsaam J, Gharavi AE, Parnassa AP, Weissbach H, Brot N, Elkon KB. Quantification of lupus anti-ribosome P antibodies using a recombinant P2 fusion protein and determination of the predicted amino acid sequence of the autoantigen in patients' mononuclear cells. Clin Exp Immunol 1989;76:165-71.
8. Bonfa E, Golombek SJ, Kaufman LD, Skelly S, Weissbach H, Brot N, et al. Association between lupus psychosis and anti-ribosomal P protein antibodies. N Engl J Med 1987;317:26.
9. Isenberg DA, Maddison PJ. Detection of antibodies to double stranded DNA and extractable nuclear antigen. J Clin Pathol 1987;40:1374-81.
10. Austin HA, Illei GG. Membranous lupus nephritis. Lupus 2005;14:65-71.
11. Ravirajan CT, Rowse L, MacGowan JR, Isenberg DA. An analysis of clinical disease activity and nephritis-associated serum autoantibody profiles in patients with systemic lupus erythematosus: a cross-sectional study. Rheumatology (Oxford) 2001;40:1405-12.
12. Ronco P, Debiec H. Molecular pathomechanisms of membranous nephropathy: from Heymann nephritis to alloimmunization. J Am Soc Nephrol 2005;16:1205-13.
13. Van Bruggen MC, Kramers C, Walgreen B, Elema JD, Kallenberg CG, van den Born J, et al. Nucleosomes and histones are present in glomerular deposits in human lupus nephritis. Nephrol Dial Transplant 1997;12:57-66.
14. Sun KH, Liu WT, Tsai CY, Tang SJ, Han SH, Yu CL. Anti-dsDNA antibodies cross-react with ribosomal P proteins expressed on the surface of glomerular mesangial cells to exert a cytostatic effect. Immunology 1995;85:262-9.
15. Koscec M, Koren E, Wolfson-Reichlin M, Fugate RD, Trieu E, Targoff IN, et al. Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture. J Immunol 1997;159:2033-41.