Numerical simulations investigating the regional and overall deposition efficiency of the human nasal cavity

Inhalation Toxicology

Volumn 20, Issue 12, 2008, Pages 1093-1100

  Shanley, Kevin T ^a   Zamankhan, Parsa ^a   Ahmadi, Goodarz ^a   Hopke, Philip K ^a   Cheng, Yung Sung ^b  

^a Wallace H Coulter School of Engineering   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHM; ARTICLE; BREATHING MECHANICS; COMPUTER PROGRAM; COMPUTER SIMULATION; FLOW RATE; IMAGE ANALYSIS; INHALATION; INSPIRATORY CAPACITY; LAMINAR AIRFLOW; NOSE AIRFLOW; NOSE CAVITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; PRIORITY JOURNAL; STEADY STATE; THREE DIMENSIONAL IMAGING;

ADMINISTRATION, INHALATION; ADULT; COMPUTER SIMULATION; HUMANS; MALE; MODELS, ANATOMIC; NASAL CAVITY; PARTICLE SIZE; PULMONARY VENTILATION;

EID: 53849119850     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370802130379     Document Type: Article

References (25)

1. Cheng, Y. S. 2003. Aerosol deposition in the extrathoracic region. Aerosol Sci. Technol. 37:659-671.
2. Cheng, Y. S., Holmes, T. D., Gao, J., Guilmette, R. A., Li, S., Surakitbanharn, Y., and Rowlings, C. 2001. Characterization of nasal spray pumps and deposition pattern in a replica of the human nasal airway. J. Aerosol Med. 14(2):267-280.
3. Cheng, Y.S., Yeh, H. C., Guilmette, R. A., Simpson, S. Q., Cheng, K. H., and Swift, D. L. 2006. Nasal deposition of ultrafine particles in human volunteers and its relationship to airway geometry. Aerosol Sci. Technol. 25:274-291.
4. Churchill, S. E., Shackelford, L. L., Georgi, J. N., and Black, M. T. 2004. Morphological variation and airflow dynamics in the human nose. Am. J. Hum. Biol. 16(6):625-638.
5. Dai, Y. T., Juang, Y. J., Wu, Y. Y., Breysse, P. N., and Hsu, D. J. 2006. In vivo measurements of inhalability of ultralarge aerosol particles in calm air by humans. J. Aerosol Sci. 37:967-973.
6. Fluent User's Manual. 2007. Version 6.3.26. Lebanon, NH: Fluent, Inc.
7. Hahn, I., Scherer, P. W., and Mozell, M. M. 1993. Velocity profiles measured for airflow through a large-scale model of the human nasal cavity, J. Appl. Physiol. 75:2273-2287.
8. Hinds, W. C. 1982. Aerosol technology: Properties, behavior, and measurement of airborne particles. New York: John Wiley and Sons.
9. Janssens, H. M., De Jongste, J. C., Fokkens, W. J., Robben, S. G. F., Wouters, K., and Tiddens, H. A. W. M. 2001. The Sophia Anatomical Infant Nose Throat (SAINT) model: A valuable tool to study aerosol deposition in infants. J. Aerosol Med. 14(4):433-441.
10. Kelly, J. T., Asgharian, B., Kimbell, J. S., and Wong, B. A. 2004 Particle deposition in human nasal airway replicas manufactured by different methods. Part I: Inertial regime particles. Aerosol Sci. Technol. 38:1063-1071.
11. Kelly, J. T., Prasad, A. K., and Wexler, A. S. 2000. Detailed flow patterns in the nasal cavity. J. Appl. Physiol. 89:323-337.
12. Keyhani, K., Scherer, P. W., and Mozell, M. M. 1995. Numerical simulation of airflow in the human nasal cavity. J. Biomech. Eng. 117:429-441.
13. Kim, S. K., and Chung, S. K. 2004. An investigation on airflow in disordered nasal cavity and its corrected models by tomographic PIV. Meas. Sci. Technol. 15:1090-1096.
14. Liu, Y., Matida, E. A., Gu, J., and Johnson, M. R. 2007. Numerical simulations of aerosol deposition in a 3-D human nasal cavity using RANS, RANS/EIM, and LES. J. Aerosol Sci. 38:693-700.
15. Martonen, T. B., and Zhang, Z. 1992. Comments on recent data for particle deposition in human nasal passages. J. Aerosol. Sci. 23(6):667-674.
16. Newman, S. P., Steed, K. P., Hooper, G., and Brickwell, J. 1995. Scintographic assessment of the oropharyngeal and nasal depositions of fusafungine from a pressurized inhaler and from a novel pump spray device. J. Pharm. Pharmacol. 47:818-821.
17. Schreck, S., Sullivan, K. J., Ho, C. M., and Chang H. K. 1993. Correlations between flow resistance and geometry in a model of the human nose. J. Appl. Physiol. 75:1767-1775.
18. Shi, H., Kleinstreuer, C., and Zhang, Z. 2007. Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness. J. Aerosol Sci. 38:398-409.
19. Su, W. C., and Cheng Y. S. 2005. Deposition of fiber in the human nasal airway.Aerosol Sci. Technol. 39:888-901.
20. Subramanian, R. P., Richardson, R. B., Morgan, K. T., Kimbell, J. S., and Guilmette, R. A. 1998. Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx, Inhal. Toxicol. 10:91-120.
21. Swift, D. L. 1991. Inspiratory inertial deposition of aerosols inhuman airway replicate casts: implication for the proposed NCRP lung model. Radiat. Prot. Dosim. 38:29-34.
22. Swift, D. L., and Proctor, D. F. 1977. Access of air to the respiratory tract. In Respiratory Defense mechanisms: Part I, eds. J. D. Brian, D. F. Proctor, and L. M. Reid, pp. 63-93. New York: Marcel Dekker.
23. Thorsson, L., Newman, S. P., Weisz, A., Trofast, E., and Mor'en, F. 1993. Nasal distribution of budesonide inhaled via a powder inhaler. Rhinology 31:7-10.
24. Zamankhan, P., Ahmadi, G., Wang, Z., Hopke, P. K., Cheng, Y. S., Su, W. C., and Leonard, D. 2006. Airflow and deposition of nanoparticles in a human nasal cavity. Aerosol. Sci. Technol. 40:463-476.
25. Zwartz, G. J., and Guilmette, R. A. 2001. Effect of flow rate on particle deposition in a replica of a human nasal aGirway, Inhal. Toxicol. 13:109-127.