Changes in hepatic risk factors, metabolic variables, body composition, and physical fitness in obese children after a one-year weight loss program

Journal of Pediatric Endocrinology and Metabolism

Volumn 21, Issue 9, 2008, Pages 837-845

  Rohrer, Tilman R ^a   Rizzo, Vincenzo F ^a   Cäsar, Jochen J ^a   Muelbredt, Oliver ^b   Sprengart, Stephanie ^a   Gortner, Ludwig ^a   Stierkorb, Eva ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Saarbrücken Olympic Training Center   (Germany)

Author keywords

Childhood obesity; Insulin resistance; Liver disease risk factors; Metabolic variables; Physical exercise; Weight loss program

Indexed keywords

LIPID; LIVER ENZYME; TRIACYLGLYCEROL;

ADOLESCENT; ARTICLE; BODY COMPOSITION; BOY; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDURANCE; EXERCISE; FEMALE; FITNESS; GIRL; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LABORATORY TEST; MALE; METABOLIC PARAMETERS; NUTRITION EDUCATION; OBESITY; OUTCOME ASSESSMENT; RISK FACTOR; RISK REDUCTION; SCHOOL CHILD; STRENGTH; WEIGHT REDUCTION;

EID: 53849086826     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2008.21.9.837     Document Type: Article

References (40)

1. Ebbeling CB, Pawlak DB, Ludwig DS. Childhood obesity: public-health crisis, common sense cure. Lancet 2002: 360: 473-482.
2. Hirasing RA, Fredriks AM, van Buuren S. Verloove-Vanhorick SP, Wit JM. Increased prevalence of overweight and obesity in Dutch children, and the detection of overweight and obesity using international criteria and new reference diagrams. Ned Tijdschr Geneeskd 2001: 145: 1303-1308.
3. Manzoli L, Ripari P, Rotolo S, Di Giacinto G, Bellomo RG, Sorgentone S, Staniscia T, Schioppa F, Romano F, Vecchiet L. [Prevalence of obesity, overweight and hypertension in children and adolescents from Abruzzo, Italy]. Ann Ig 2005; 17: 419-431.
4. Wabitsch M, Kunze D, Keller E, Kiess W, Kromeyer-Hauschild K. Obesity in children and adolescents in Germany. Significant and persistent increase of prevalence. Appeal to treatment. Fortschr Med Orig 2002; 120: 99-106.
5. Fishbein MH, Miner M, Mogren C, Chalekson J. The spectrum of fatty liver in obese children and the relationship of serum aminotransferases to severity of steatosis. J Pediatr Gastroenterol Nutr 2003; 36: 54-61.
6. Reinehr T, de Sousa G, Andler W. Longitudinal analyses among overweight, insulin resistance, and cardiovascular risk factors in children. Obes Res 2005; 13: 1824-1833.
7. Ugur-Altun B, Altun A, Gerenli M, Tugrul A. The relationship between insulin resistance assessed by HOMA-IR and serum osteoprotegerin levels in obesity. Diabetes Res Clin Pract 2005; 68: 217-222.
8. Yeste D, Betancourth S, Gussinye M, Potau N, Carrascosa A. Glucose intolerance in obese children and adolescents. Med Clin (Barc) 2005; 125: 405-408.
9. Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994; 107: 1103-1109.
10. Golik A, Rubio A, Weintraub M, Byrne L. Elevated serum liver enzymes in obesity: a dilemma during clinical trials. Int J Obes 1991; 15: 797-801.
11. Palmer M, Schaffner F. Effect of weight reduction on hepatic abnormalities in overweight patients. Gastroenterology 1990; 99: 1408-1413.
12. Elitsur Y, Lawrence Z. The prevalence of obesity and elevated liver enzymes in children at a university gastroenterology clinic. W V Med J 2004; 100: 67-69.
13. Kinugasa A, Tsunamoto K, Furukawa N, Sawada T, Kusunoki T, Shimada N. Fatty liver and its fibrous changes found in simple obesity of children. J Pediatr Gastroenterol Nutr 1984; 3: 408-414.
14. Moran JR. Ghishan FK, Halter SA, Greene HL. Steatohepatitis in obese children: a cause of chronic liver dysfunction. Am J Gastroenterol 1983; 78: 374-377.
15. Vajro P, Fontanella A, Perna C, Orso G, Tedesco M, De Vincenzo A. Persistent hyperaminotransferasemia resolving after weight reduction in obese children. J Pediatr 1994; 125: 239-241.
16. Carrel AL, Clark RR, Peterson SE, Nemeth BA, Sullivan J, Allen DB. Improvement of fitness, body composition, and insulin sensitivity in overweight children in a school-based exercise program: a randomized, controlled study. Arch Pediatr Adolesc Med 2005; 159: 963-968.
17. Nassis GP, Papantakou K, Skenderi K, Triandafillo-poulou M, Kavouras SA, Yannakoulia M, Chrousos GP, Sidossis LS. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism 2005; 54: 1472-1479.
18. Kromeyer-Hauschild K, Wabitsch M, Kunze D, Geller F, Geiß H, Hesse V, et al. Perzentile für den Body-mass-Index für das Kindes- und Jugendalter unter Heranziehung verschiedener deutscher Stichproben. Monatsschr Kinderheilkd 2001; 149: 807-818.
19. Allard P, Delvin EE, Paradis G, Hanley JA, O'Loughlin J, Lavallée C, Levy E, Lambert M. Distribution of fasting plasma insulin, free fatty acids, and glucose concentrations and of homeostasis model assessment of insulin resistance in a representative sample of Quebec children and adolescents. Clin Chem 2003; 49: 644-649.
20. Sitzmann FC. Referenzwerte für das Kindesalter. Stuttgart: Hippokrates Verlag, 1995.
21. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
22. Houtkooper LB, Lohman TG, Going SB, Hall MC. Validity of bioelectric impedance for body composition assessment in children. J Appl Physiol 1989; 66: 814-821.
23. Houtkooper LB, Going SB, Lohman TG, Roche AF, Van LM. Bioelectrical impedance estimation of fat-free body mass in children and youth: a cross-validation study. J Appl Physiol 1992; 72: 366-373.
24. Faude O, Nowacki P, Urhausen A. Comparison of non-invasive tests to assess cardio-respiratory fitness in school children. Dtsch Z Sportmed 2004; 55: 232-236.
25. Hebestreit H, Lawrenz W, Zelger O, Kienast W, Jüngst B. Ergometrie im Kindes- und Jugendalter. Monatsschr Kinderheilkd 1997; 145: 1326-1336.
26. Baldridge AD, Perez-Atayde AR, Graeme-Cook F, Higgins L, Lavine JE. Idiopathic steatohepatitis in childhood: a multicenter retrospective study. J Pediatr 1995; 127: 700-704.
27. Mandato C, Lucariello S, Licenziati MR, Franzese A, Spagnuolo MI, Ficarella R, Pacilio M, Amitrano M, Capuano G, Meli R, Vajro P. Metabolic, hormonal, oxidative, and inflammatory factors in pediatric obesity-related liver disease. J Pediatr 2005; 147: 62-66.
28. Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003; 37: 1202-1219.
29. Strauss RS, Barlow SE, Dietz WH. Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents. J Pediatr 2000; 136: 727-733.
30. Falck-Ytter Y, Younossi ZM, Marchesini G, McCullough AJ. Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 2001; 21: 17-26.
31. Parks EJ, Hellerstein MK. Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms. Am J Clin Nutr 2000; 71: 412-433.
32. Eliakim A, Scheett TP, Newcomb R, Mohan S, Cooper DM. Fitness, training, and the growth hormone-insulin-like growth factor I axis in prepubertal girls. J Clin Endocrinol Metab 2001; 86: 2797-2802.
33. Travers SH, Labarta JI, Gargosky SE, Rosenfeld RG, Jeffers BW, Eckel RH. Insulin-like growth factor binding protein-I levels are strongly associated with insulin sensitivity and obesity in early pubertal children. J Clin Endocrinol Metab 1998; 83: 1935-1939.
34. Reinehr T, Kiess W, Kapellen T, Andler W. Insulin sensitivity among obese children and adolescents, according to degree of weight loss. Pediatrics 2004; 114: 1569-1573.
35. 1H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 2002; 51: 1022-1027.
36. Chumlea WC, Guo SS. Bioelectrical impedance and body composition: present status and future directions. Nutr Rev 1994; 52: 123-131.
37. Katzmarzyk PT, Leon AS, Wilmore JH, Skinner JS, Rao DC, Rankinen T, Bouchard C. Targeting the metabolic syndrome with exercise: evidence from the HERITAGE Family Study. Med Sci Sports Exerc 2003; 35: 1703-1709.
38. Katzmarzyk PT, Leon AS, Rankinen T, Gagnon J, Skinner JS, Wilmore JH, Rao DC, Bouchard C. Changes in blood lipids consequent to aerobic exercise training related to changes in body fatness and aerobic fitness. Metabolism 2001; 50: 841-848.
39. Wilmore JH, Green JS, Stanforth PR, Gagnon J, Rankinen T, Leon AS, Rao DC, Skinner JS, Bouchard C. Relationship of changes in maximal and submaximal aerobic fitness to changes in cardiovascular disease and non-insulin-dependent diabetes mellitus risk factors with endurance training: the HERITAGE Family Study. Metabolism 2001; 50: 1255-1263.
40. Mo-suwan L, Pongprapai S, Junjana C, Puetpaiboon A. Effects of a controlled trial of a school-based exercise program on the obesity indexes of preschool children. Am J Clin Nutr 1998; 68: 1006-1011.