Variation in the large-scale organization of gene expression levels in the hippocampus relates to stable epigenetic variability in behavior

PLoS ONE

Volumn 3, Issue 10, 2008, Pages

  Alter, Mark D ^a   Rubin, Daniel B ^a   Ramsey, Keri ^b   Halpern, Rebecca ^b   Stephan, Dietrich A ^b   Abbott, L F ^a   Hen, Rene ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN FUNCTION; CONTROLLED STUDY; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE LOCATION; GENETIC ORGANIZATION; GENETIC STABILITY; GENETIC VARIABILITY; HIPPOCAMPUS; LIFE EVENT; MICROARRAY ANALYSIS; MONOZYGOTIC TWINS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTBREEDING; PHENOTYPE; SPECIES DIFFERENCE; ANIMAL; ANIMAL BEHAVIOR; BAGG ALBINO MOUSE; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETIC EPIGENESIS; METABOLISM; METHODOLOGY;

MUS;

ANIMALS; BEHAVIOR, ANIMAL; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC VARIATION; HIPPOCAMPUS; MICE; MICE, INBRED BALB C; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 53749104645     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003344     Document Type: Article

References (37)

1. Wong AH, Gottesman II, Petronis A (2005) Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1: R11-18.
2. Petronis A (2006) Epigenetics and twins: three variations on the theme. Trends Genet.
3. Kendler KS, Halberstadt LJ, Butera F, Myers J, Bouchard T, et al. (2007) The similiarity of facial expressions in response to emotion-inducing films in reared-apart twins. Psychol Med. pp 1-9.
4. Bouchard TJ, Jr, Lykken DT, McGue M, Segal NL, Tellegen A (1990) Sources of human psychological differences: the Minnesota Study of Twins Reared Apart. Science 250: 223-228.
5. Gartner K (1990) A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals? Lab Anim 24: 71-77.
6. Weaver IC, Szyf M, Meaney MJ (2002) From maternal care to gene expression: DNA methylation and the maternal programming of stress responses. Endocr Res 28: 699.
7. Weaver IC, Champagne FA, Brown SE, Dymov S, Sharma S, et al. (2005) Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J Neurosci 25: 11045-11054.
8. Ueda HR, Hayashi S, Matsuyama S, Yomo T, Hashimoto S, et al. (2004) Universality and flexibility in gene expression from bacteria to human. Proc Natl Acad Sci U S A 101: 3765-3769.
9. Kuznetsov VA, Knott GD, Bonner RF (2002) General statistics of stochastic process of gene expression in eukaryotic cells. Genetics 161: 1321-1332.
10. Ray J, Hansen S (2005) Temperamental development in the rat: the first year. Dev Psychobiol 47: 136-144.
11. Kazlauckas V, Schuh J, Dall'Igna OP, Pereira GS, Bonan CD, et al. (2005) Behavioral and cognitive profile of mice with high and low exploratory phenotypes. Behav Brain Res 162: 272-278.
12. Meaney MJ, Mitchell JB, Aitken DH, Bhatnagar S, Bodnoff SR, et al. (1991) The effects of neonatal handling on the development of the adrenocortical response to stress: implications for neuropathology and cognitive deficits in later life. Psychoneuroendocrinology 16: 85-103.
13. Liu D, Diorio J, Day JC, Francis DD, Meaney MJ (2000) Maternal care, hippocampal synaptogenesis and cognitive development in rats. Nat Neurosci 3: 799-806.
14. Ponder CA, Kliethermes CL, Drew MR, Muller J, Das K, et al. (2007) Selection for contextual fear conditioning affects anxiety-like behaviors and gene expression. Genes Brain Behav 6: 736-749.
15. Ponder CA, Huded CP, Munoz MB, Gulden FO, Gilliam TC, et al. (2008) Rapid selection response for contextual fear conditioning in a cross between C57BL/6J and A/J: behavioral, QTL and gene expression analysis. Behav Genet 38: 277-291.
16. Bishop JO, Morton JG, Rosbash M, Richardson M (1974) Three abundance classes in HeLa cell messenger RNA. Nature 250: 199-204.
17. Axel R, Feigelson P, Schutz G (1976) Analysis of the complexity and diversity of mRNA from chicken liver and oviduct. Cell 7: 247-254.
18. Limpert E, Stahel W, Abbt M (2001) Log-normal distributions across the sciences: keys and clues. Bioscence 51: 341-352.
19. Weaver IC, Meaney MJ, Szyf M (2006) Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proc Natl Acad Sci U S A 103: 3480-3485.
20. Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, et al. (2004) Epigenetic programming by maternal behavior. Nat Neurosci 7: 847-854.
21. Li B, Carey M, Workman JL (2007) The role of chromatin during transcription. Cell 128: 707-719.
22. Shen S, Li J, Casaccia-Bonnefil P (2005) Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain. J Cell Biol 169: 577-589.
23. Tao R, de Zoeten EF, Ozkaynak E, Chen C, Wang L, et al. (2007) Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 13: 1299-1307.
24. Lattal KM, Barrett RM, Wood MA (2007) Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. Behav Neurosci 121: 1125-1131.
25. Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH (2007) Recovery of learning and memory is associated with chromatin remodelling. Nature 447: 178-182.
26. Levenson JM, O'Riordan KJ, Brown KD, Trinh MA, Molfese DL, et al. (2004) Regulation of histone acetylation during memory formation in the hippocampus. J Biol Chem 279: 40545-40559.
27. Versey CG, Hawk JD, Lattal KM, Stein JM, Fabian SA, et al. (2007) Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci 27: 6128-6140.
28. Weaver IC, La Plante P, Weaver S, Parent A, Sharma S, et al. (2001) Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites. Mol Cell Endocrinol 185: 205-218.
29. Weaver IC, Diorio J, Seckl JR, Szyf M, Meaney MJ (2004) Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites. Ann N Y Acad Sci 1024: 182-212.
30. Meaney MJ, Aitken DH, Bodnoff SR, Iny LJ, Tatarewicz JE, et al. (1985) Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions. Behav Neurosci 99: 765-770.
31. Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, et al. (1997) Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 277: 1659-1662.
32. Tsankova N, Renthal W, Kumar A, Nestler EJ (2007) Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 8: 355-367.
33. Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B (2008) Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods.
34. Mulero-Navarro S, Esteller M (2008) Epigenetic biomarkers for human cancer: The time is now. Crit Rev Oncol Hematol.
35. Smrt RD, Eaves-Egenes J, Barkho BZ, Santistevan NJ, Zhao C, et al. (2007) Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol Dis 27: 77-89.
36. Zhou Z, Hong EJ, Cohen S, Zhao WN, Ho HY, et al. (2006) Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 52: 255-269.
37. Lim WK, Wang K, Lefebvre C, Califano A (2007) Comparative analysis of microarray normalization procedures: effects on reverse engineering gene networks. Bioinformatics 23: i282-288.