Effect of grape seed extract on lead induced hypertension and heart rate in rat

Pakistan Journal of Biological Sciences

Volumn 11, Issue 6, 2008, Pages 882-887

  Badavi, Mohammad ^a   Mehrgerdi, Fatemeh Zarea ^a   Sarkaki, Alireza ^a   Naseri, Mohammad Kazem Gharib ^a   Dianat, Mahin ^a  

^a AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Grape seed extract; Heart rate; Hypertension oxidative stress; Lead; Rat

Indexed keywords

LEAD; LOW DENSITY LIPOPROTEIN; PLANT EXTRACT;

ANIMAL; ARTICLE; BLOOD; BLOOD PRESSURE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GRAPE; HEART RATE; HYPERTENSION; MALE; METABOLISM; METHODOLOGY; OXIDATIVE STRESS; PHYTOTHERAPY; RAT; TEMPERATURE; TIME; WISTAR RAT;

ANIMALS; BLOOD PRESSURE; HEART RATE; HYPERTENSION; LEAD; LIPOPROTEINS, LDL; MALE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; TEMPERATURE; TIME FACTORS; VITIS;

ANIMALIA; RATTUS; RATTUS NORVEGICUS; VITACEAE;

EID: 53749104222     PISSN: 10288880     EISSN: 18125735     Source Type: Journal    
DOI: 10.3923/pjbs.2008.882.887     Document Type: Article

References (29)

1. Ademuyiwa, O., R.N. Ugbaja, F. Idumebor and O. Adebawo, 2005. Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria. Lipids Health Dis. [Serial online] 4: 19. http://www.lipidworldcom/content/4/1/19 Accessed January 12, 2008.
2. Agarwal, C., R. Veluri, M. Kaur, S.C. Chou, J.A. Thompson and R. Agarwal, 2007. Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3, 3′-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis, 28 (7): 1478-1484.
3. Aldini, G., M. Carini, A. Piccoli, G. Rossoni and R.M. Facino, 2003. Procyanidins from grape seeds protect endothelial cells from peroxynirrite damage and enhance endothelium-dependent relaxation in human artery: New evidences for cardio-protection. Life Sci., 73 (22): 2883-2898.
4. Boscolo, P. and M. Carmignani, 1988. Neurohumoral blood pressure regulation in lead exposure. Environ. Health Perspect., 78: 101-106.
5. Carmignani, M., A.R. Volpe, P. Boscolo, N. Qiao, G.M. Di, A. Grilli and M. Felaco, 2000. Catecholamine and nitric oxide systems as targets of chronic lead exposure in inducing selective functional impairment. Life Sci., 68 (4): 401-415.
6. Ding, Y., H.C. Gonick and N.D. Vaziri, 2000. Lead promotes hydroxyl radical generation and lipid peroxidation in cultured aortic endothelial cells. Am. J. Hypertens., 13 (5, part 1): 552-555.
7. Ding, Y., H.C. Gonick, N.D. Vaziri, K. Liang and L. Wei, 2001. Lead-induced hypertension. IIII. Increased hydroxyl radical production. Am. J. Hypertens., 14 (2): 169-173.
8. Du, Y., H. Guo and H. Lou, 2007. Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes. J. Agric. Food Chem., 55 (5): 1695-1701.
9. Gonick, H.C., Y. Ding, S.C. Bondy, Z. Ni and N.D. Vaziri, 1997. Lead-induced hypertension: Interplay of nitric oxide and reactive oxygen species. Hypertension, 30 (6): 1487-1492.
10. Joshi, S.S., C.A. Kuszynski and D. Bagchi, 2001. The cellular and molecular basis of health benefits of grape seed proanthocyanidin extract. Curr. Pharm. Biotechnol., 2 (2): 187-200.
11. Khahl-Manesh, F., H.C. Gonick, E.W. Weiler, B. Prins, M.A. Weber and R.E. Purdy, 1993. Lead-induced hypertension: Possible role of endothelial factors. Am. J. Hypertens., 6 (9): 723-729.
12. Kim, H., 2005. New nutrition, proteomics and how both can enhance studies in cancer prevention and therapy. J. Nutr., 135 (11): 2715-2718.
13. Lai, C.C., H.H. Lin, C.W. Chen, S.H. Chen and T.H. Chiu, 2002. Excitatory action of lead on rat sympathetic preganglionic neurons in vitro and in vivo. Life Sci., 71 (9): 1035-1045.
14. Marques, M., I. Millas, A. Jimenez, E. Garcia-Colis, J.A. Rodriguez-Feo, S. Velasco, A. Barrientos, S. Casado and A. Lopez-Farre, 2001. Alteration of the soluble guanylate cyclase system in the vascular wall of lead-induced hypertension in rats. J. Am. Soc. Nephrol., 12 (12): 2594-2600.
15. Mitral, C.K., W.B. Harrell and C.S. Mehta, 1995. Interaction of heavy metal toxicants with brain constitutive nitric oxide synthase. Mol. Cell Biochem., 149-150: 263-265.
16. Ni, Z., S. Hou, C.H. Barton and N.D. Vaziri, 2004. Lead exposure raises superoxide and hydrogen peroxide in human endothelial and vascular smooth muscle cells. Kidney Int., 66 (6): 2329-2336.
17. Nomoto, H., M. Iigo, H. Hamada, S. Kojima and H. Tsuda, 2004. Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis. Nutr. Cancer, 49(1): 81-88.
18. Patrick, L., 2006. Lead toxicity, a review of the literature. Part 1: Exposure, evaluation and treatment. Alt. Med. Rev., 11 (1): 2-22.
19. Parsons, P.J., C. Geraghty and M.F. Verostek, 2001. An assessment of contemporary atomic spectroscopic techniques for the determination of lead in blood and urine matrices. Spectrochimica Acta Part B: Atomic Spectroscopy, 56 (9): 1593-1604.
20. Purdy, R.E., J.R. Smith, Y. Ding, F. Oveisi, N.D. Vaziri and H.C. Gonick, 1997. Lead-induced hypertension is not associated with altered vascular reactivity in vitro. Am. J. Hypertens., 10 (9): 997-1003.
21. Roychowdhury, S., G. Wolf, G. Keilhoff, D. Bagchi and T. Horn, 2001. Protection of primary glial cells by grape seed proanthocyanidin extract against nitrosative/oxidative stress. Nitric Oxide, 5(2): 137-149.
22. Shi, J., I. Yu, J.E. Pohrly and Y. Kakud 2003. Polyphenolics in grape seed biochemistry and functionality. J. Med. Food, 6 (4): 291-299.
23. Vaziri, N.D., Y. Ding, Z. Ni and H.C. Gonick, 1997. Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: Effect of lazaroid therapy. Kidney Int., 52 (4): 1042-1046.
24. Vaziri, N.D., Y. Ding and Z. Ni, 1999a. Nitric oxide synthase expression in the course of lead-induced hypertension. Hypertension, 34 (4): 558-562.
25. Vaziri, N.D., K. Liang and Y. Ding, 1999b. Increased nitric oxide inactivation by reactive oxygen species in lead-induced hypertension. Kidney Int., 56 (4): 1492-1498.
26. Vaziri, N.D., C.Y. Lin, F. Farmand and R.K. Sindhu, 2003. Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead-induced hypertension. Kidney Int., 63 (1): 186-194.
27. Vaziri, N.D. and D.A. Sica, 2004. Lead-induced hypertension: Role of oxidative stress. Curr. Hypertens. Rep., 6 (4): 314-320.
28. Veluri, R., R.P.S. Lingh, Z. Liu, J.A. Thompson, R. Agarwal and C. Agarwal, 2006. Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis, 27 (7): 1445-1453.
29. Victery, W., 1988. Evidence for effects of chronic lead exposure on blood pressure in experimental animals: An overview. Environ. Health Perspect., 78: 71-76.