Melatonin ameliorates calcium homeostasis in myocardial and ischemia-reperfusion injury in chronically hypoxic rats

Journal of Pineal Research

Volumn 45, Issue 4, 2008, Pages 373-382

  Yeung, H M ^a   Hung, M W ^a   Fung, M L ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Antioxidant; Calcium; Cardioprotection; Chronic hypoxia; Ischemia; Melatonin

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CALCIUM; LACTATE DEHYDROGENASE; MALONALDEHYDE; MELATONIN; OXYGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BRAIN INFARCTION SIZE; CALCIUM BLOOD LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; HEMATOCRIT; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SARCOPLASMIC RETICULUM;

ANIMALS; ANOXIA; ANTIOXIDANTS; BLOTTING, WESTERN; CALCIUM; CARDIOMEGALY; CELLS, CULTURED; HEMATOCRIT; HOMEOSTASIS; L-LACTATE DEHYDROGENASE; MALONDIALDEHYDE; MELATONIN; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SPECTROMETRY, FLUORESCENCE; TIME FACTORS;

EID: 53749101521     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2008.00601.x     Document Type: Article

References (68)

1. Ostadal B, Kolar F. Cardiac adaptation to chronic high-altitude hypoxia: beneficial and adverse effects. Respir Physiol Neurobiol 2007 158 : 224 236.
2. Kolar F, Ostadal B. Molecular mechanisms of cardiac protection by adaptation to chronic hypoxia. Physiol Res 2004 53 (Suppl. 1 S3 S13.
3. Kong X, Tweddell JS, Gross GJ et al. Sarcolemmal and mitochondrial K(atp)channels mediate cardioprotection in chronically hypoxic hearts. J Mol Cell Cardiol 2001 33 : 1041 1045.
4. Pei JM, Yu XC, Fung ML et al. Impaired G(s)alpha and adenylyl cyclase cause beta-adrenoceptor desensitization in chronically hypoxic rat hearts. Am J Physiol Cell Physiol 2000 279 : C1455 C1463.
5. Shan J, Yu XC, Fung ML et al. Attenuated "cross talk" between kappa-opioid receptors and beta-adrenoceptors in the heart of chronically hypoxic rats. Pflugers Arch 2002 444 : 126 132.
6. Pei JM, Kravtsov GM, Wu S et al. Calcium homeostasis in rat cardiomyocytes during chronic hypoxia: a time course study. Am J Physiol Cell Physiol 2003 285 : C1420 C1428.
7. 2 radicals during reperfusion after prolonged myocardial ischemia. Am J Physiol Heart Circ Physiol 2001 280 : H2649 H2657.
8. 2 radicals in intact hearts with ischemia and reperfusion. Am J Physiol Heart Circ Physiol 2003 284 : H566 H574.
9. Zweier JL, Wang P, Kuppusamy P. Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy. J Biol Chem 1995 270 : 304 307.
10. Halestrap AP, Clarke SJ, Javadov SA. Mitochondrial permeability transition pore opening during myocardial reperfusion - a target for cardioprotection. Cardiovasc Res 2004 61 : 372 385.
11. Juhaszova M, Zorov DB, Kim SH et al. Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest 2004 113 : 1535 1549.
12. Lounsbury KM, Hu Q, Ziegelstein RC. Calcium signaling and oxidant stress in the vasculature. Free Radic Biol Med 2000 28 : 1362 1369.
13. Waypa GB, Marks JD, Mack MM et al. Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circ Res 2002 91 : 719 726.
14. Rosen J, Than NN, Koch D et al. Interactions of melatonin and its metabolites with the ABTS cation radical: extension of the radical scavenger cascade and formation of a novel class of oxidation products, C2-substituted 3-indolinones. J Pineal Res 2006 41 : 374 381.
15. Tan DX, Manchester LC, Terron MP et al. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007 42 : 28 42.
16. Lee YM, Chen HR, Hsiao G et al. Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. J Pineal Res 2002 33 : 72 80.
17. Tan DX, Manchester LC, Reiter RJ et al. Ischemia/reperfusion-induced arrhythmias in the isolated rat heart: prevention by melatonin. J Pineal Res 1998 25 : 184 191.
18. Szarszoi O, Asemu G, Vanecek J et al. Effects of melatonin on ischemia and reperfusion injury of the rat heart. Cardiovasc Drugs Ther 2001 15 : 251 257.
19. Sahna E, Acet A, Ozer MK et al. Myocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatonin. J Pineal Res 2002 33 : 234 238.
20. Sahna E, Olmez E, Acet A. Effects of physiological and pharmacological concentrations of melatonin on ischemia-reperfusion arrhythmias in rats: can the incidence of sudden cardiac death be reduced? J Pineal Res 2002 32 : 194 198.
21. Ressmeyer AR, Mayo JC, Zelosko V et al. Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction. Redox Rep 2003 8 : 205 213.
22. Guenther AL, Schmidt SI, Laatsch H et al. Reactions of the melatonin metabolite AMK (N1-acetyl-5-methoxykynuramine) with reactive nitrogen species: formation of novel compounds, 3-acetamidomethyl-6-methoxycinnolinone and 3-nitro-AMK. J Pineal Res 2005 39 : 251 260.
23. Reiter RJ, Tan DX, Manchester LC et al. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence. Cell Biochem Biophys 2001 34 : 237 256.
24. Tan DX, Reiter RJ, Manchester LC et al. Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger. Curr Top Med Chem 2002 2 : 181 197.
25. Allegra M, Reiter RJ, Tan DX et al. The chemistry of melatonin's interaction with reactive species. J Pineal Res 2003 34 : 1 10.
26. Antolin I, Rodriguez C, Sainz RM et al. Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes. FASEB J 1996 10 : 882 890.
27. Rodriguez C, Mayo JC, Sainz RM et al. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004 36 : 1 9.
28. Maldonado MD, Murillo-Cabezas F, Terron MP et al. The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma. J Pineal Res 2007 42 : 1 11.
29. Tjong YW, Chen Y, Liong EC et al. Chronic hypoxia modulates the function and expression of melatonin receptors in the rat carotid body. J Pineal Res 2006 40 : 125 134.
30. Kazez A, Demirbag M, Ustundag B et al. The role of melatonin in prevention of intestinal ischemia-reperfusion injury in rats. J Pediatr Surg 2000 35 : 1444 1448.
31. Eskiocak S, Tutunculer F, Basaran UN et al. The effect of melatonin on protein oxidation and nitric oxide in the brain tissue of hypoxic neonatal rats. Brain Dev 2007 29 : 19 24.
32. Hung MW, Tipoe GL, Poon AM et al. Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia. J Pineal Res 2008 44 : 214 221.
33. Tjong YW, Li MF, Hung MW et al. Melatonin ameliorates hippocampal nitric oxide production and large conductance calcium-activated potassium channel activity in chronic intermittent hypoxia. J Pineal Res 2008 44 : 234 243.
34. Cao CM, Xia Q, Gao Q et al. Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning. J Pharmacol Exp Ther 2005 312 : 644 650.
35. 2+ exchange and ryanodine receptor activities in ischemia-reperfusion. Am J Physiol Cell Physiol 2007 292 : C2046 C2056.
36. Wu S, Li HY, Wong TM. Cardioprotection of preconditioning by metabolic inhibition in the rat ventricular myocyte. Involvement of kappa-opioid receptor. Circ Res 1999 84 : 1388 1395.
37. Ho JC, Wu S, Kam KW et al. Effects of pharmacological preconditioning with U50488H on calcium homeostasis in rat ventricular myocytes subjected to metabolic inhibition and anoxia. Br J Pharmacol 2002 137 : 739 748.
38. 2+ exchange and consequences for relaxation in guinea pig cardiac myocytes. Am J Physiol 1994 267 : H477 H487.
39. 2+ exchanger in the rabbit. J Physiol 2003 553 : 229 242.
40. Yu XC, Li HY, Wang HX et al. U50,488H inhibits effects of norepinephrine in rat cardiomyocytes-cross-talk between kappa-opioid and beta-adrenergic receptors. J Mol Cell Cardiol 1998 30 : 405 413.
41. 2+ and contraction in isolated guinea pig cardiac myocytes. Am J Physiol 1995 268 : H1045 H1052.
42. 2+-ATPase increases cardiac contractility in transgenic mouse hearts. Circ Res 1998 83 : 1205 1214.
43. 2+-ATPase. Circ Res 1998 83 : 889 897.
44. Sallinen P, Manttari S, Leskinen H et al. The effect of myocardial infarction on the synthesis, concentration and receptor expression of endogenous melatonin. J Pineal Res 2007 42 : 254 260.
45. Acuna CD, Escames G, Carazo A et al. Melatonin, mitochondrial homeostasis and mitochondrial-related diseases. Curr Top Med Chem 2002 2 : 133 151.
46. Poeggeler B, Thuermann S, Dose A et al. Melatonin's unique radical scavenging properties - roles of its functional substituents as revealed by a comparison with its structural analogs. J Pineal Res 2002 33 : 20 30.
47. Mahal HS, Sharma HS, Mukherjee T. Antioxidant properties of melatonin: a pulse radiolysis study. Free Radic Biol Med 1999 26 : 557 565.
48. Poeggeler B, Reiter RJ, Tan DX et al. Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis. J Pineal Res 1993 14 : 151 168.
49. Simko F, Paulis L. Melatonin as a potential antihypertensive treatment. J Pineal Res 2007 42 : 319 322.
50. Mayo JC, Sainz RM, Antoli I et al. Melatonin regulation of antioxidant enzyme gene expression. Cell Mol Life Sci 2002 59 : 1706 1713.
51. Okatani Y, Wakatsuki A, Kaneda C. Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain. J Pineal Res 2000 28 : 89 96.
52. Wakatsuki A, Okatani Y, Shinohara K et al. Melatonin protects fetal rat brain against oxidative mitochondrial damage. J Pineal Res 2001 30 : 22 28.
53. Okatani Y, Wakatsuki A, Shinohara K et al. Melatonin protects against oxidative mitochondrial damage induced in rat placenta by ischemia and reperfusion. J Pineal Res 2001 31 : 173 178.
54. Wakatsuki A, Okatani Y, Shinohara K et al. Melatonin protects against ischemia/reperfusion-induced oxidative damage to mitochondria in fetal rat brain. J Pineal Res 2001 31 : 167 172.
55. Leon J, Acuna-Castroviejo D, Escames G et al. Melatonin mitigates mitochondrial malfunction. J Pineal Res 2005 38 : 1 9.
56. Schillaci G, Vaudo G, Pasqualini L et al. Left ventricular mass and systolic dysfunction in essential hypertension. J Hum Hypertens 2002 16 : 117 122.
57. Cloward TV, Walker JM, Farney RJ et al. Left ventricular hypertrophy is a common echocardiographic abnormality in severe obstructive sleep apnea and reverses with nasal continuous positive airway pressure. Chest 2003 124 : 594 601.
58. Lorell BH, Carabello BA. Left ventricular hypertrophy: pathogenesis, detection, and prognosis. Circulation 2000 102 : 470 479.
59. +) cycling proteins. J Mol Cell Cardiol 2002 34 : 897 918.
60. Chamberlain BK, Volpe P, Fleischer S. Calcium-induced calcium release from purified cardiac sarcoplasmic reticulum vesicles. General characteristics. J Biol Chem 1984 259 : 7540 7546.
61. Bers DM. Calcium fluxes involved in control of cardiac myocyte contraction. Circ Res 2000 87 : 275 281.
62. Osada M, Netticadan T, Tamura K et al. Modification of ischemia-reperfusion-induced changes in cardiac sarcoplasmic reticulum by preconditioning. Am J Physiol 1998 274 : H2025 H2034.
63. Reiken S, Gaburjakova M, Guatimosim S et al. Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol. J Biol Chem 2003 278 : 444 453.
64. Birkeland JA, Sejersted OM, Taraldsen T et al. EC-coupling in normal and failing hearts. Scand Cardiovasc J 2005 39 : 13 23.
65. Gomez AM, Valdivia HH, Cheng H et al. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 1997 276 : 800 806.
66. 2+ content in isolated failing and nonfailing human myocardium. Circ Res 1999 85 : 38 46.
67. Salie R, Harper I, Cillie C et al. Melatonin protects against ischaemic-reperfusion myocardial damage. J Mol Cell Cardiol 2001 33 : 343 357.
68. Tengattini S, Reiter RJ, Tan DX et al. Cardiovascular diseases: protective effects of melatonin. J Pineal Res 2008 44 : 16 25.