Proposed new addition to 3Rs for ethical and humane use of rats in pharmacokinetic studies - 'Recycle'

Drug Metabolism Letters

Volumn 2, Issue 3, 2008, Pages 193-197

  Balani, Suresh K ^a   Lu, Chuang ^a   Cardoza, Kym ^a   Berg, Cicely ^a   Zhang, Ji ^a   Lee, Frank W ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

3Rs; 4Rs; Pharmacokinetics; Recycle; Reduction; Refinement; Replacement

Indexed keywords

FLUCONAZOLE; TOLBUTAMIDE;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL TESTING ALTERNATIVE; ANIMAL TESTING RECYCLING; ANIMAL TESTING REDUCTION; ANIMAL TESTING REFINEMENT; ANIMAL TESTING REPLACEMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG HALF LIFE; DRUG RESEARCH; EXPERIMENTAL ANIMAL WELFARE; LOW DRUG DOSE; MALE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; REPRODUCIBILITY; RESEARCH ETHICS; SINGLE DRUG DOSE; SPRAGUE DAWLEY RAT; TREATMENT DURATION;

ANIMAL EXPERIMENTATION; ANIMAL WELFARE; ANIMALS; FLUCONAZOLE; MALE; MODELS, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TOLBUTAMIDE;

ANIMALIA; RATTUS;

EID: 53749100134     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231208785425827     Document Type: Article

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