CPT21, a novel compound with anti-proliferative effect against gastric cancer cell SGC7901

Investigational New Drugs

Volumn 26, Issue 6, 2008, Pages 517-524

  Zhang, Bo ^a   Luo, Yu ^b   Weng, Qinjie ^a   He, Qiaojun ^a   Lu, Wei ^b   Yang, Bo ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

Apoptosis; Camptothecin; Gastric cancer; Xenograft

Indexed keywords

7 [(3 PIPERIDYL) 1 PROPINYL]CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; CPT 21; DNA TOPOISOMERASE; IRINOTECAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROCASPASE 9; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOMACH CANCER; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CAMPTOTHECIN; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; DNA BREAKS, DOUBLE-STRANDED; DNA REPLICATION; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; STOMACH NEOPLASMS; TIME FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 53749099768     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9120-9     Document Type: Article

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