Characterization of a lymphocyte subset displaying a unique regulatory activity in human decidua

International Immunology

Volumn 20, Issue 9, 2008, Pages 1147-1154

  Amsalem, Hagai ^a   Gaiger, Anat ^a   Mizrahi, Sa'ar ^b   Yagel, Simcha ^a   Rachmilewitz, Jacob ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Decidua; Lipopolysaccharide; Suppression; T cells; Tolerance

Indexed keywords

CD3 ANTIBODY; CD3 ANTIGEN; CD4 ANTIGEN; ENDOTOXIN; GAMMA INTERFERON; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 5; LIPOPOLYSACCHARIDE; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

ANTIGEN EXPRESSION; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL ACTIVITY; CELL CONTACT; CELL ISOLATION; CHORIOAMNIONITIS; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DECIDUA; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PREMATURE LABOR; PRIORITY JOURNAL; REGULATORY DECIDUAL LYMPHOCYTE; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; BIOSYNTHESIS; FIRST TRIMESTER PREGNANCY; FLOW CYTOMETRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PREGNANCY;

CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DECIDUA; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; PREGNANCY; PREGNANCY TRIMESTER, FIRST; T-LYMPHOCYTES, REGULATORY;

EID: 53749096965     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxn072     Document Type: Article

References (25)

1. Thellin, O., Coumans, B., Zorzi, W., Igout, A. and Heinen, E. 2000. Tolerance to the foeto-placental 'graft': Ten ways to support a child for nine months. Curr. Opin. Immunol. 12:731.
2. Moreau, P., Paul, P., Rouas-Freiss, N., Kirszenbaum, M., Dausset, J. and Carosella, E. D. 1998. Molecular and immunologic aspects of the nonclassical HLA class I antigen HLA-G: Evidence for an important role in the maternal tolerance of the fetal allograft. Am. J. Reprod. Immunol. 40:136.
3. Munn, D. H., Zhou, M., Attwood, J. T. et al. 1998. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281:1191.
4. Wegmann, T. G., Lin, H., Guilbert, L. and Mosmann, T. R. 1993. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol. Today 14:353.
5. Raghupathy, R. 1997. Th1-type immunity is incompatible with successful pregnancy. Immunol. Today 18:478.
6. Piccinni, M. P., Giudizi, M. G., Biagiotti, R. et al. 1995. Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J. Immunol. 155:128.
7. Billingham, R. E., Brent, L. and Medawar, P. B. 1953. Activity acquired tolerance of foreign cells. Nature 172:603.
8. Schuppe, H. C. and Meinhardt, A. 2005. Immune privilege and inflammation of the testis. Chem. Immunol. Allergy 88:1.
9. Moffett-King, A. 2002. Natural killer cells and pregnancy. Nat. Rev. Immunol. 2:656.
10. King, A., Burrows, T., Verma, S., Hiby, S. and Loke, Y. W. 1998. Human uterine lymphocytes. Hum. Reprod. Update 4:480.
11. Li, X. F., Charnock-Jones, D. S., Zhang, E. et al. 2001. Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells. J. Clin. Endocrinol. Metab. 86:1823.
12. Tayade, C., Black, G. P., Fang, Y. and Croy, B. A. 2006. Differential gene expression in endometrium, endometrial lymphocytes, and trophoblasts during successful and abortive embryo implantation. J. Immunol. 176:148.
13. Curiel, T. J., Coukos, G., Zou, L. et al. 2004. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 10:942.
14. Sasaki, Y., Sakai, M., Miyazaki, S., Higuma, S., Shiozaki, A. and Saito, S. 2004. Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol. Hum. Reprod. 10:347.
15. Zenclussen, A. C., Gerlof, K., Zenclussen, M. L. et al. 2006. Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface. Eur. J. Immunol. 36:82.
16. Rachmilewitz, J., Riely, G. J. and Tykocinski, M. L. 1999. Placental protein 14 functions as a direct T-cell inhibitor. Cell. Immunol. 191:26.
17. Hanna, J., Wald, O., Goldman-Wohl, D. et al. 2003. CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells. Blood 102:1569.
18. Sakaguchi, S. 2005. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6:345.
19. Somerset, D. A., Zheng, Y., Kilby, M. D., Sansom, D. M. and Drayson, M. T. 2004. Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology 112:38.
20. Heikkinen, J., Mottonen, M., Alanen, A. and Lassila, O. 2004. Phenotypic characterization of regulatory T cells in the human decidua. Clin. Exp. Immunol. 136:373.
21. Thornton, A. M. and Shevach, E. M. 1998. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
22. Newton, E. R. 2005. Preterm labor, preterm premature rupture of membranes, and chorioamnionitis. Clin. Perinatol. 32:571.
23. Murphy, S. P., Fast, L. D., Hanna, N. N. and Sharma, S. 2005. Uterine NK cells mediate inflammation-induced fetal demise in IL-10-null mice. J. Immunol. 175:4084.
24. Hanna, J., Goldman-Wohl, D., Hamani, Y. et al. 2006. Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat. Med. 12:1065.
25. Koopman, L. A., Kopcow, H. D., Rybalov, B. et al. 2003. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J. Exp. Med. 198:1201.