Hemodynamic responses to simulated weightlessness of 24-h head-down bed rest and KAATSU blood flow restriction

European Journal of Applied Physiology

Volumn 104, Issue 4, 2008, Pages 727-737

  Nakajima, Toshiaki ^a   Iida, Haruko ^a   Kurano, Miwa ^a   Takano, Haruhito ^a   Morita, Toshihiro ^a   Meguro, Kentaro ^a   Sato, Yoshiaki ^a   Yamazaki, Yoshihisa ^b   Kawashima, Sino ^c   Ohshima, Hiroshi ^c   Tachibana, Shouichi ^c   Ishii, Naokata ^a   Abe, Takashi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Tsukuba Space Center   (Japan)

^c JAPAN AEROSPACE EXPLORATION AGENCY   (Japan)

Author keywords

6 head down tilt bed rest; Autonomic function; Cardiovascular deconditioning; KAATSU training; Space flight; Sympathetic activity

Indexed keywords

NORADRENALIN; RENIN; VASOPRESSIN;

ADULT; ARTICLE; BED REST; BLOOD VOLUME; BODY MASS; BODY POSTURE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; HYPOTENSION; INFERIOR CAVA VEIN; MALE; MICROGRAVITY; MUSCLE TRAINING; NORMAL HUMAN; PLASMA VOLUME; PRESYNCOPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIMULATION; SITTING; SPACE FLIGHT; STANDING; SYMPATHETIC TONE; VEIN BLOOD FLOW; VEIN DIAMETER; VENOUS RETURN; WEIGHTLESSNESS;

ADULT; BED REST; BLOOD PRESSURE; CARDIAC OUTPUT; ECHOCARDIOGRAPHY; HEAD-DOWN TILT; HEART RATE; HEMODYNAMICS; HUMANS; MALE; MUSCLE, SKELETAL; NOREPINEPHRINE; REGIONAL BLOOD FLOW; RENIN; RESISTANCE TRAINING; STROKE VOLUME; VASOPRESSINS; WEIGHTLESSNESS SIMULATION;

EID: 53749089909     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-008-0834-3     Document Type: Article

References (38)

1. Abe T, Kearns CF, Sato Y (2006) Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training. J Appl Physiol 100:1460-1466. doi: 10.1152/ japplphysiol.01267.2005
2. Arbeille P, Herault S, Fomina G, Roumy J, Alferova I, Gharib C (1999) Influences of thigh cuffs on the cardiovascular system during 7-day head-down bed rest. J Appl Physiol 87:2168-2176
3. Brown CM, Hecht MJ, Neundörfer B, Hilz MJ (2003) Effects of lower body negative pressure on cardiac and vascular responses to carotid barorelex stimulation. Physiol Res 52:637-645
4. Buckey JC Jr, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, Moore WE et al (1996) Orthostatic intolerance after spaceflight. J Appl Physiol 81:7-18
5. Duranteau J, Pussard E, Berdeaux A, Giudicelli JF (1995) Role of the renin-angiotensin system in systemic and regional vascular responses to orthostatic stress in healthy volunteers. Fundam Clin Pharmacol 9:479-487
6. Eiken O, Lind F, Bjurstedt H (1986) Effects of blood volume distribution on ventilatory variables at rest and during exercise. Acta Physiol Scand 127:507-512
7. Fortney SM, Hyatt KH, Davis JE, Vogel JM (1991) Changes in body fluid compartments during a 28-day bed rest. Aviat Space Environ Med 62:97-104
8. Frey MAB, Mathes KL, Hoffler GW (1986) Cardiovascular responses of women to lower body negative pressure. Aviat Space Environ Med 57:531-538
9. Fritsch-Yelle JM, Whitson PA, Bondar RL, Brown TE (1996) Subnormal norepinephrine release relates to presyncope in astronauts after spaceflight. J Appl Physiol 81:2134-2141
10. Fujita S, Abe T, Drummond MJ, Cadenas JG, Dreyer HC, Sato Y et al (2007) Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis. J Appl Physiol 103:903-910. doi: 10.1152/japplphysiol.00195.2007
11. Furlan R, Jacob G, Palazzolo L, Rimoldi A, Diedrich A, Harris PA et al (2001) Sequential modulation of cardiac autonomic control induced by cardiopulmonary and arterial baroreflex mechanisms. Circulation 104:2932-2937. doi: 10.1161/hc4901.100360
12. Gaffney FA, Nixon JV, Karlsson ES, Campbell W, Dowdey AB, Blomqvist CG (1985) Cardiovascular deconditioning produced by 20 hours of bed rest with head-down tilt (-5) in middle-aged healthy men. Am J Cardiol 56:634-638. doi: 10.1016/0002-9149(85)91025-2
13. Güell A, Braak L, Pavy-Le Traon A, Gharib C (1990) Cardiovascular deconditioning during weightlessness stimulation and the use of lower body negative pressure as a countermeasure to orthostatic intolerance. Acta Astronaut 21:667-672. doi: 10.1016/0094-5765(90)90078-Y
14. Güell A, Cornac A, Faurat MM, Gauquelin G, Pavy-Le Traon A, Gharib C (1992) Lower body negative pressure as a countermeasure against orthostatic intolerance for long term space flight. Acta Astronaut 27:103-107. doi: 10.1016/0094-5765(92)90185-L
15. Herault S, Fomina G, Alferova I, Kotovskaya A, Poliakov V, Arbeille P (2000) Cardiac, arterial and venous adaptation to weightlessness during 6-month MIR spaceflights with and without thigh cuffs (bracelets). Eur J Appl Physiol 81:384-390. doi: 10.1007/s004210050058
16. Hughson RL, Maillet A, Gauquelin G, Arbeille P, Yamamoto Y, Gharib C (1995) Investigation of hormonal effects during 10-h head-down tilt on heart rate and blood pressure variability. J Appl Physiol 78:583-596
17. Iida H, Kurano M, Takano H, Kubota N, Morita T, Meguro K et al (2007) Hemodynamic and neurohumoral responses to the restriction of femoral blood flow by KAATSU in healthy subjects. Eur J Appl Physiol 100:275-285. doi: 10.1007/s00421-007-0430-y
18. Lathers CM, Charles JB (1993) Use of lower body negative pressure to counter symptoms of orthostatic intolerance in patients, bed rest subjects, and astronauts. J Clin Pharmacol 33:1071-1085
19. Leach CS, Altchuler SI, Cintron-Trevino NM (1983) The endocrine and metabolic responses to space flight. Med Sci Sports Exerc 15:432-440. doi: 10.1249/00005768-198315050-00016
20. Lee SM, Bennett BS, Hargens AR, Watenpaugh DE, Ballard RE, Murthy G et al (1997) Upright exercise or supine lower body negative pressure exercise maintains exercise responses after bed rest. Med Sci Sports Exerc 29:892-900. doi: 10.1097/00005768-199707000-00008
21. Lee SM, Schneider SM, Boda WL, Watenpaugh DE, Macias BR, Meyer RS et al (2007) Supine LBNP exercise maintains exercise capacity in male twins during 30-d bed rest. Med Sci Sports Exerc 39:1315-1326. doi: 10.1249/ mss.0b013e31806463d9
22. Lindgren KN, Kraft D, Ballard RE, Tucker A, Hargens AR (1998) Venoconstrictive thigh cuffs impede fluid shifts during simulated microgravity. Aviat Space Environ Med 69:1052-1058
23. Melchior FM, Srinivasan RS, Thullier PH, Clere JM (1994) Simulation of cardiovascular response to lower body negative pressure from 0 to -40 mmHg. J Appl Physiol 77:630-640
24. Millet C, Custaud MA, Allevard AM, Gharib C, Gauquelin-Koch G, Fortrat JO (2000) Adaptations to a 7-day head-down bed rest with thigh cuffs. Med Sci Sports Exerc 32:1748-1756. doi: 10.1097/00005768-200010000-00014
25. Murthy G, Watenpaugh DE, Ballard RE, Hargens AR (1994) Exercise against lower body negative pressure as a countermeasure for cardiovascular and musculoskeletal deconditioning. Acta Astronaut 33:89-96. doi: 10.1016/ 0094-5765(94)90112-0
26. Nicogossian A, Pool S, Sawin C (1995) Status and efficacy of countermeasures to physiological deconditioning from space flight. Acta Astronaut 36:393-398. doi: 10.1016/0094-5765(95)00123-9
27. Nixon JV, Murray RG, Bryant C, Johnson RL Jr, Mitchell JH, Holland OB et al (1979) Early cardiovascular adaptation to stimulated zero gravity. J Appl Physiol 46:541-548
28. Norsk P, Stadeager C, Johansen LB, Warberg J, Bie P, Foldager N et al (1993) Volume-homeostatic mechanisms in humans during a 12-h posture change. J Appl Physiol 75:349-356
29. Sandler H, Popp RL, Harrison DC (1988) The hemodynamic effects of repeated bed rest exposure. Aviat Space Environ Med 59:1047-1054
30. Schneider SM, Watenpaugh DE, Lee SM, Ertl AC, Williams WJ, Ballard RE et al (2002) Lower-body negative-pressure exercise and bed-rest-mediated orthostatic intolerance. Med Sci Sports Exerc 34:1446-1453. doi: 10.1097/ 00005768-200209000-00008
31. Stevens PM, Lamb LE (1965) Effects of lower body negative pressure on the cardiovascular system. Am J Cardiol 16:506-515. doi: 10.1016/ 0002-9149(65)90027-5
32. Takano H, Morita T, Iida H, Asada K, Kato M, Uno K et al (2005) Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow. Eur J Appl Physiol 95:65-73. doi: 10.1007/s00421-005-1389-1
33. Takarada Y, Takazawa H, Sato Y, Takebayashi S, Tanaka Y, Ishii N (2000) Effects of resistance exercise combined with moderate vascular occlusion on muscle function in humans. J Appl Physiol 88:2097-2106
34. Tomaselli CM, Frey MA, Kenney RA, Hoffler GW (1987) Hysteresis in response to descending and ascending lower-body negative pressure. J Appl Physiol 63:719-725
35. Tomaselli CM, Frey MA, Kenney RA, Hoffler W (1990) Effect of a central redistribution of fluid volume on response to lower-body negative pressure. Aviat Space Environ Med 61:38-42
36. Watenpaugh DE, Ballard RE, Stout MS, Murthy G, Whalen RT, Hargens AR (1994) Dynamic leg exercise improves tolerance to lower body negative pressure. Aviat Space Environ Med 65:412-418
37. Watenpaugh DE, Ballard RE, Schneider SM, Lee SM, Ertl AC, William JM et al (2000) Supine lower body negative pressure exercise during bed rest maintains upright exercise capacity. J Appl Physiol 89:218-227
38. Wolthuis RA, Bergman SA, Nicogossian AE (1974) Physiological effects of locally applied reduced pressure in man. Physiol Rev 54:566-595