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Part 153 in the series, Studies on novel synthetic methodologies.
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Part 153 in the series, "Studies on novel synthetic methodologies".
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Preparation of the catalyst: To a solution of H3MO 12O40·24H2O (100mg, 0.1 equiv by Wt) in MeOH (5 mL) silica gel (900 mg, 0.9 equiv by wt, 100-200 mesh) was added slowly. The mixture was stirred at room temperature for 6 h. Evoparation of MeOH under reduced pressure offorded dry yellowish powder of the catalyst. General procedure for the synthesis of 1,8-dioxooctahydroxanthenes: To a mixture of an aldehyde (1 mmol) and dimedone (2.2 mmol) in MeOH (5 mL) PMA·SiO 2 (100mg) was added. The mixture was stirred at room temperature and the reaction was monitored by TLC. After completion the reaction mixture was filtered and the catalyst was recovered after washing the residue with MeOH (2 × 5 mL, The filtrate was concentrated and the residue was subjected to column chromatography (silica gel, hexane-EtOAc) to obtain pure 1,8-dioxooctahydroxanthene. The recovered catalyst was reused three times subsequently for the s
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