Changes in markers of cobalamin status after cessation of oral B-vitamin supplements in elderly people with mild cobalamin deficiency

European Journal of Clinical Nutrition

Volumn 62, Issue 10, 2008, Pages 1248-1251

  Eussen, S J P M ^a   Ueland, P M ^b   Hiddink, G J ^c   Schneede, J ^b,d   Blom, H J ^e   Hoefnagels, W H L ^f   van Staveren, W A ^a   de Groot, L C P G M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF BERGEN   (Norway)

^c The Dutch Dairy Association   (Netherlands)

^d UMEÅ UNIVERSITY   (Sweden)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COBALAMIN; FOLIC ACID; METHYLMALONIC ACID; PLACEBO; TRANSCOBALAMIN; VITAMIN B GROUP;

AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DISEASE SEVERITY; FOLLOW UP; GERIATRIC CARE; HUMAN; NUTRITIONAL ASSESSMENT; TREATMENT DURATION; VITAMIN BLOOD LEVEL; VITAMIN DEFICIENCY; VITAMIN SUPPLEMENTATION;

AGED, 80 AND OVER; BIOLOGICAL AVAILABILITY; BIOLOGICAL MARKERS; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; FOLLOW-UP STUDIES; HUMANS; MALE; METHYLMALONIC ACID; NUTRITIONAL STATUS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TIME FACTORS; TREATMENT OUTCOME; VITAMIN B 12; VITAMIN B 12 DEFICIENCY; VITAMIN B COMPLEX;

EID: 53649099643     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1602834     Document Type: Article

References (15)

1. Amin S, Spinks T, Ranicar A, Short MD, Hoffbrand AV (1980). Long-term clearance of [57Co]cyanocobalamin in vegans and pemicious anaemia. Clin Sci (Lond) 58, 101-103.
2. Baik HW, Russell RM (1999). Vitamin B12 deficiency in the elderly. Annu Rev Nutr 19, 357-377.
3. Eussen SJ, de Groot LC, Clarke R, Schneede J, Ueland PM, Hoefnagels WH et al. (2005). Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: A dose-finding trial. Arch Intern Med 165, 1167-1172.
4. Eussen SJ, de Groot LC, Joosten LW, Bloo RJ, Clarke R, Ueland PM et al. (2006). Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: A randomized, placebo-controlled trial. Am J Clin Nutr 84, 361-370.
5. Hathcock JN, Troendle GJ (1991). Oral cobalamin for treatment of pemicious anemia? JAMA 265, 96-97.
6. Henning BF, Tepel M, Riezler R, Naurath HJ (2001). Long-term effects of vitamin B(12), folate, and vitamin B(6) supplements in elderly people with normal serum vitamin B(12) concentrations. Gerontology 47 30-35.
7. Hvas AM, Nexo E (2005). Holotranscobalamin - a first choice assay for diagnosing early vitamin B deficiency? J Intern Med 257, 289-298.
8. Immulite (2000) Available at: http://diagnostics.siemens.com/siemens/ en_GLOBAL/gg_diag_FBAs/files/package_inserts/immulite_2000/Anemia/ 12kvb-22.pdf Accessed January 24, 2007.
9. Kuzminski AM, Del-Giacco EJ, Allen RH, Stabler SP, Lindenbaum J (1998). Effective treatment of cobalamin deficiency with oral cobalamin. Blood 92, 1191-1198.
10. Lindenbaum J, Healton EB, Savage DG, Brust JC, Garrett TJ, Podell ER et al. (1988). Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 318, 1720-1728.
11. Morkbak AL, Heimdal RM, Emmens K, Molloy A, Hvas AM, Schneede J et al. (2005). Evaluation of the technical performance of novel holotranscobalamin (holoTC) assays in a multicenter European demonstration project. Clin Chem Lab Med 43, 1058-1064.
12. Schneede J, Ueland PM (2005). Novel and established markers of cobalamin deficiency: Complementary or exclusive diagnostic strategies. Semin Vasc Med 5, 140-155.
13. Stabler SP (2000). B12 and nutrition. In: Banjeree R (ed) Chemistry and Biochemistry of B12, Wiley and Sons: New York, pp 343-365.
14. van Asselt DZ, de Groot LC, van Staveren WA, Blom HJ, Wevers RA, Biemond I et al. (1998). Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects. Am J Clin Nutr 68, 328-334.
15. Windelberg A, Arseth O, Kvalheim G, Ueland PM (2005). Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry. Clin Chem 51, 2103-2109.