Basidiomycete metabolites attenuate virulence properties of Candida albicans in vitro

Mycoses

Volumn 51, Issue 6, 2008, Pages 505-514

  Falkensammer, Barbara ^a   Pleyer, Lisa ^a   Ressler, Sigrun ^a   Berg, Albrecht ^b   Borg Von Zepelin, Margarethe ^c   Nagl, Markus ^a   Lass Flörl, Cornelia ^a   Speth, Cornelia ^a   Dierich, Manfred P ^a   Würzner, Reinhard ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b HANS KNÖLL INSTITUTE   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Adhesion; Basidiomycetes; Candida; Protease inhibitor; Sap release; Viability

Indexed keywords

ASPARTIC PROTEINASE; AUREOQUINONE; BESTATIN; LACCARIDIONE A; LACCARIDIONE B; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BASIDIOMYCETES; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FUNGAL VIABILITY; FUNGUS CULTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; VIRULENCE;

ANTIBIOSIS; BASIDIOMYCOTA; BENZOQUINONES; CANDIDA ALBICANS; CELL ADHESION; CELL LINE; ENDOTHELIAL CELLS; EPITHELIAL CELLS; HUMANS; LEUCINE; PROTEASE INHIBITORS; QUINONES;

BASIDIOMYCOTA; CANDIDA; CANDIDA ALBICANS;

EID: 53549121711     PISSN: 09337407     EISSN: 14390507     Source Type: Journal    
DOI: 10.1111/j.1439-0507.2008.01515.x     Document Type: Article

References (33)

1. Odds FC (ed.). Ecology of Candida and epidemiology of candidosis. Bailliere Tindall, 2nd edition. Oxford : Elsevier, 1998 : 68 92.
2. Coleman DC, Sullivan DJ, Bennett DE, Moran GP, Barry HJ, Shanley DB. Candidiasis: the emergence of a novel species, Candida dubliniensis. AIDS 1997 11 : 557 67.
3. Odds FC (ed.). Factors that predispose the host to candidosis. Bailliere Tindall, 2nd edition. Oxford : Elsevier, 1998 : 93 114.
4. Hube B, Sanglard D, Odds FC et al. Disruption of each of the aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infect Immun 1997 65 : 3529 38.
5. Davies DR. The structure and function of aspartic proteinases. Annu Rev Biophys Chem 1990 19 : 189 215.
6. Homma M, Kanbe T, Hiroji C, Tanak K. Detection of intracellular forms of secretory aspartic proteinase in Candida albicans. J Gen Microbiol 1991 138 : 627 33.
7. Staib F. Proteolysis and pathogenicity of Candida albicans strains. Mycopathol Mycol Appl 1969 37 : 345 8.
8. Staib F. Serum proteins as nitrogen source for yeast-like fungi. Sabouraudia 1965 4 : 187 93.
9. Ghannoum M, Abu-Elteen K. Correlative relationship between production, adherence, and pathogenicity of various strains of Candida albicans. J Med Vet Mycol 1986 24 : 407 13.
10. Schaller M, Korting HC, Schäfer W, Bastert J, WenChieh C, Hube B. Secreted aspartic proteinase activity contributes to tissue damage in a model of human oral candidosis. Mol Microbiol 1999 34 : 169 80.
11. Kaminishi H, Miyaguchi H, Tamaki T et al. Degradation of humoral host defense by Candida albicans proteinase. Infect Immun 1995 63 : 984 8.
12. Beausejour A, Grenier D, Goulet JP, Deslauriers N. Proteolytic activation of the interleukin-1β precursor by Candida albicans. Infect Immun 1998 66 : 676 81.
13. De Bernardis F, Arancia S, Moreli L et al. Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis. J Infect Dis 1999 179 : 201 8.
14. Nelson RD, Shibata N, Podzorsky RP, Heron MJ. Candida mannan: chemistry, suppression, of cell mediated immunity, and possible mechanisms of action. Clin Microbiol Rev 1991 4 : 1 19.
15. White TC, Agabian N. Candida albicans secreted aspartyl proteinases: isoenzyme pattern is petermined by cell type, and levels are determined by environmental factors. Am Soc Microbiol 1995 177 : 5215 21.
16. Berg A, Görls H, Dörfelt H, Walther G, Schlegel B, Gräfe U. Aureoquinone, a new protease inhibitor from Aureobasidium spp. J Antibiot 2000 53 : 1293 5.
17. Berg A, Reiber K, Dörfelt H, Walther G, Schlegel B, Gräfe U. Laccaridiones A and B, new protease inhibitors from Laccaria amethystea. J Antibiot 2000 53 : 1313 6.
18. Pleyer L. Influence of novel bioactive substances on adhesion and protease release and activity of Candida. Dissertation. Austria : University of Innsbruck, 2002.
19. Würzner R, Langgartner M, Spötl L et al. Temperature-dependent surface expression of the beta-2-integrin analogue of Candida albicans and its role in adhesion to the human endothelium. Exp Clin Immunogenet 1996 13 : 161 72.
20. Nagl M, Gruber A, Fuchs A et al. Impact of N-chlorotaurine on viability and production of secreted aspartyl proteinases of Candida spp. Antimicrob Agents Chemother 2002 46 : 1996 9.
21. Patterson EK. Inhibition by Bestatin of a mouse ascites tumor dipeptidase. Reversal by certain substrates. J Biol Chem 1989 264 : 8004 11.
22. Gruber A, Lukasser-Vogl E, Borg-von Zepelin M, Dierich MP, Wurzner R. Human immunodeficiency virus type 1 gp160 and gp41 binding to Candida albicans selectively enhances candidal virulence in vitro. J Infect Dis 1998 177 : 1057 63.
23. Ollert MW, Wende C, Gorlich M et al. Increased expression of Candida albicans secretory proteinase, a putative virulence factor, in isolates from human immunodeficiency virus-positive patients. J Clin Microbiol 1995 33 : 2543 9.
24. Cassone A, De Bernardis F, Torosantucci A, Taconelli E, Tumbarello M, Cauda R. In vitro and in vivo activity of human immunodeficiency virus protease inhibitors. J Infect Dis 1999 180 : 448 53.
25. Bektic J, Lell CP, Fuchs A et al. HIV protease inhibitors attenuate adherence of Candida albicans to epithelial cells in vitro. Immunol Med Microbiol 2001 31 : 65 71.
26. Pfaller MA, Diekema DJ. Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida ablicans and Apergillus fumigatus. J Clin Microbiol 2004 42 : 4419 31.
27. Pranav Kumar SK, Kulkarni VM. Insights into the selective inhibition of Candida albicans secreted aspartyl protease: a docking analysis study. Bioorg Med Chem 2001 10 : 1153 70.
28. Naglik JR, Rodgers CA, Shirlaw PJ et al. Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections. J Infect Dis 2003 188 : 469 79.
29. Ibrahim AS, Fille SG, Sanglard D, Edwards JE, Hube B. Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells. Infect Immun 1998 66 : 3003 5.
30. Falkensammer B, Pilz G, Bektić J, Imwidthaya P, Jöhrer K, Speth C, Lass-Flörl C, Dierich MP, Würzner R. Absent reduction by HIV protease inhibitors of Candida albicans adhesion to endothelial cells. Mycoses 2007 50 : 172 7.
31. MacDonald F. Secretion of inducible proteinase by pathogenic Candida species. Sabouraudia 1984 22 : 79 82.
32. Rüchel R, Böning B, Borg M. Characterization of a secreted proteinase of Candida parapsilosis and evidence for the absence of the enzyme during infection in vivo. Infect Immun 1986 53 : 411 9.
33. Pichova I, Pavlickova L, Dostal J et al. Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae. Inhibition with peptidomimetic inhibitors. Eur J Biochem 2001 268 : 2669 77.