Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2

Diabetologia

Volumn 51, Issue 11, 2008, Pages 2078-2087

  Van Deursen, D ^a   Jansen, H ^a   Verhoeven, A J M ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

Glucose; Hepatic lipase; Human hepatoma cells; Metabolic syndrome; Transcription; Upstream stimulatory factor

Indexed keywords

GLUCOSE; LIVER TRIACYLGLYCEROL LIPASE; NUCLEAR PROTEIN; UPSTREAM STIMULATORY FACTOR 1; UPSTREAM STIMULATORY FACTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL CULTURE; CELL LEVEL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DYSLIPIDEMIA; ENZYME REGULATION; ENZYME RELEASE; GENE SILENCING; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; LIVER CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; STREPTOZOCIN DIABETES; UPREGULATION;

ANIMALS; CELL LINE; CELL LINE, TUMOR; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE; HEPATOBLASTOMA; HUMANS; LIPASE; LIVER NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS (GENETICS); RATS; RATS, WISTAR; TRANSCRIPTION, GENETIC; UP-REGULATION; UPSTREAM STIMULATORY FACTORS;

EID: 53549115902     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-1125-6     Document Type: Article

References (50)

1. GI Varughese J Tomson GY Lip 2005 Type 2 diabetes mellitus: a cardiovascular perspective Int J Clin Pract 59 798 816
2. BE Sobel DJ Schneider 2005 Cardiovascular complications in diabetes mellitus Curr Opin Pharmacol 5 143 148
3. GM Reaven 2005 Compensatory hyperinsulinemia and the development of an atherogenic lipoprotein profile: the price paid to maintain glucose homeostasis in insulin-resistant individuals Endocrinol Metab Clin North Am 34 49 62
4. J Nigro N Osman AM Dart PJ Little 2006 Insulin resistance and atherosclerosis Endocr Rev 27 242 259
5. SJ Bredie CJ Tack P Smits AF Stalenhoef 1997 Nonobese patients with familial combined hyperlipidemia are insulin resistant compared with their nonaffected relatives Arterioscler Thromb Vasc Biol 17 1465 1471
6. JD Brunzell JE Hokanson 1999 Dyslipidemia of central obesity and insulin resistance Diabetes Care 22 Suppl 3 C10 C13
7. HN Ginsberg 2006 Review: Efficacy and mechanisms of action of statins in the treatment of diabetic dyslipidemia J Clin Endocrinol Metab 91 383 392
8. H Jansen AJM Verhoeven EJG Sijbrands 2002 Hepatic lipase: a pro- or anti-atherogenic protein? J Lipid Res 43 1352 1362
9. SS Deeb A Zambon MC Carr AF Ayyobi JD Brunzell 2003 Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet J Lipid Res 44 1279 1286
10. S Rashid T Watanabe T Sakaue GF Lewis 2003 Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity Clin Biochem 36 421 429
11. H Allayee KM Dominguez BE Aouizerat 2000 Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia J. Lipid Res 41 245 252
12. KCB Tan SWM Shiu BYM Chu 1999 Roles of hepatic lipase and cholesteryl ester transfer protein in determining low density lipoprotein subfraction distribution in Chinese patients with non-insulin-dependent diabetes mellitus Atherosclerosis 145 273 278
13. II Berk-Planken N Hoogerbrugge RP Stolk AH Bootsma H Jansen 2003 Atorvastatin dose-dependently decreases hepatic lipase activity in type 2 diabetes: effect of sex and the LIPC promoter variant Diabetes Care 26 427 432
14. C Baynes AD Henderson W Richmond DG Johnston RS Elkeles 1992 The response of hepatic lipase and serum lipoproteins to acute hyperinsulinaemia in type 2 diabetes Eur J Clin Invest 22 341 346
15. H Jansen AJM Verhoeven L Weeks 1997 Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients Arterioscler Thromb Vasc Biol 17 2837 2842
16. J Pihlajamäki L Karjalainen P Karhapää 2000 G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia Arterioscler Thromb Vasc Biol 20 1789 1795
17. GF Lewis S Murdoch K Uffelman 2004 Hepatic lipase mRNA, protein, and plasma enzyme activity is increased in the insulin-resistant, fructose-fed Syrian golden hamster and is partially normalized by the insulin sensitizer rosiglitazone Diabetes 53 2893 2900
18. MC Carr JE Hokanson SS Deeb JQ Purnell ES Mitchell JD Brunzell 1999 A hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women Arterioscler Thromb Vasc Biol 19 2701 2707
19. L Nimmo AJ McColl JZ Rosankiewicz W Richmond RS Elkeles 1997 Regulation of hepatic lipase expression in HepG2 cells Biochem Soc Trans 25 S689
20. GJ Botma D van Deursen D Vieira M van Hoek H Jansen AJM Verhoeven 2005 Sterol-regulatory-element binding protein inhibits upstream stimulator factor-stimulated hepatic lipase gene expression Atherosclerosis 179 61 67
21. AY Tu JJ Albers 2001 Glucose regulates the transcription of human genes relevant to HDL metabolism Diabetes 50 1851 1856
22. GJ Botma AJM Verhoeven H Jansen 2001 Hepatic lipase promoter activity is reduced by the C-480G and G-216A substitutions present in the common LIPC variant and is increased by upstream stimulatory factor Atherosclerosis 154 625 632
23. S Corre MD Galibert 2005 Upstream stimulating factors: highly versatile stress-responsive transcription factors Pigment Cell Res 18 337 348
24. PB Iynedjian 1998 Identification of upstream stimulatory factor as transcriptional activator of the liver promoter of the glucokinase gene Biochem J 333 705 712
25. D Wang HS Sul 1997 Upstream stimulatory factor binding to the E-box at -65 is required for insulin regulation of the fatty acid synthase promoter J Biol Chem 272 26367 26374
26. M Nowak A Helleboid-Chapman H Jakel 2005 Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the phosphatidylinositol 3-kinase pathway: role of upstream stimulatory factor Mol Cell Biol 25 1537 1548
27. A Ribeiro D Pastier D Kardassis J Chambaz P Cardot 1999 Cooperative binding of upstream stimulatory factor and hepatic nuclear factor 4 drives the transcription of the human apolipoprotein A-II gene J Biol Chem 274 1216 1255
28. D Pastier JM Lacorte J Chambaz P Cardot A Ribeiro 2002 Two initiator-like elements are required for the combined activation of the human apolipoprotein C-III promoter by upstream stimulatory factor and hepatic nuclear factor-4 J Biol Chem 277 15199 15206
29. E Salero C Gimenez F Zafra 2003 Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene Biochem J 370 979 986
30. VS Vallet M Casado AA Henrion 1998 Differential roles of upstream stimulatory factors 1 and 2 in the transcriptional response of liver genes to glucose J Biol Chem 273 20175 20179
31. F Smih P Rouet S Lucas 2002 Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose Diabetes 51 293 300
32. M Bidder JS Shao N Charlton-Kachigian AP Loewy CF Semenkovich DA Towler 2002 Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities J Biol Chem 277 44485 44496
33. C Weigert K Brodbeck M Sawadogo HU Häring ED Schleicher 2004 Upstream stimulatory factor (USF) proteins induce human TGF-b1 gene activation via the glucose-response element -1013/-1002 in mesangial cells J Biol Chem 279 15908 15915
34. S Wang J Skorczewiski X Feng L Mei JE Murphy-Ullrich 2004 Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-β activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2 J Biol Chem 279 34311 34322
35. MC Ng K Miyake WY So 2005 The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population Diabetologia 48 2018 2024
36. P Pajukanta HE Lilja JS Sinsheimer 2004 Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1) Nat Genet 36 371 376
37. H Coon Y Xin PN Hopkins RM Cawthon SJ Hasstedt SC Hunt 2005 Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides Hum Genet 117 444 451
38. K Komulainen M Alanne K Auro 2006 Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies PloS Genetics 2 e69
39. CC Shoulders RP Naoumova 2004 USF1 implicated in the aetiology of familial combined hyperlipidaemia and the metabolic syndrome Trends Mol Med 10 362 365
40. J Naukkarinen M Gentile A Soro-Paavonen 2005 USF1 and dyslipidemias: converging evidence for a functional intronic variant Hum Mol Genet 14 2595 2605
41. W Putt J Palmen V Nicaud 2004 Variation in USF1 shows haplotype effects, gene:gene and gene:environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II Hum Mol Genet 13 1587 1597
42. J Hoffstedt M Ryden H Wahrenberg V van Harmelen P Arner 2005 Upstream transcription factor-1 gene polymorphism is associated with increased adipocyte lipolysis J Clin Endocrinol Metab 90 5356 5360
43. van Deursen D, Botma GJ, Jansen H, Verhoeven AJM (2008) Down-regulation of hepatic lipase expression by elevation of cAMP in human hepatoma but not adrenocortical cells. Mol Cell Endocrinol doi: 10.1016/j.mce.2008.07.004
44. HR McMurray DJ McCance 2003 Human papillomavirus type 16 E6 activates TERT gene transcription through induction of c-Myc and release of USF-mediated repression J Virol 77 9852 9861
45. S Van Linthout A Riad N Dhayat 2007 Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy Diabetologia 50 1977 1986
46. L Ma LN Robinson HC Towle 2006 ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver J Biol Chem 281 28721 28730
47. K Cartharius K Frech K Grote 2005 MatInspector and beyond: promoter analysis based on transcription factor binding sites Bioinformatics 21 2933 2942
48. T Kawaguchi K Osatomi H Yamashita T Kabashima K Uyeda 2002 Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase J Biol Chem 277 3829 3835
49. H Jansen A van Tol J Auwerx G Skretting B Staels 1992 Opposite regulation of hepatic lipase and lecithin: cholesterol acyltransferase by glucocorticoids in rats Biochim Biophys Acta 1128 181 185
50. E Jensen P Hansson CH Floren A Nilsson P Nilsson-Ehle 1989 Cell-density-dependent release of hepatic lipase from cultured rat hepatocytes Horm Metab Res 21 4 7