Update on chronic urticaria: Focusing on mechanisms

Current Opinion in Allergy and Clinical Immunology

Volumn 8, Issue 5, 2008, Pages 433-437

  Młynek, Agnieszka ^a   Maurer, Marcus ^b   Zalewska, Anna ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Basophil; Chronic urticaria; Coagulation cascade; Disease severity; Mast cell

Indexed keywords

ANTIHISTAMINIC AGENT; BIOLOGICAL MARKER; CD63 ANTIGEN; CD69 ANTIGEN; DESLORATADINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HISTAMINE; HORMONE; INTERLEUKIN 3; LEVOCETIRIZINE; OMALIZUMAB; PADGEM PROTEIN; RUPATADINE; SEX HORMONE; THROMBOCYTE ACTIVATING FACTOR RECEPTOR;

AUTOIMMUNITY; BASOPHIL; BLOOD; BLOOD CLOTTING; BLOOD INJECTION; CHRONIC URTICARIA; DISEASE ACTIVITY; DISEASE COURSE; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG MECHANISM; DRUG MEGADOSE; FIBRINOLYSIS; HISTAMINE RELEASE; HUMAN; IMMUNOREACTIVITY; MAST CELL; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; PSYCHOLOGICAL ASPECT; QUALITY OF LIFE; REVIEW; SERUM; SERUM INJECTION; TREATMENT PLANNING;

ANTI-ALLERGIC AGENTS; BASOPHILS; CHRONIC DISEASE; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; HUMANS; MAST CELLS; URTICARIA;

EID: 53549092237     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e32830f9119     Document Type: Review

References (40)

1. Greaves MW, Tan KT. Chronic urticaria: recent advances. Clin Rev Allergy Immunol 2007; 33:134-143. This is an up-to-date review on broadly speaking chronic urticaria
2. Zuberbier T, Maurer M. Urticaria: current opinions about etiology, diagnosis and therapy. Acta Derm Venereol 2007; 87:106-205. This is a compact review on classification, diagnosis, and treatment of numerous urticaria subtypes.
3. Guldbakke KK, Khachemoune A. Etiology, classification, and treatment of urticaria. Cutis 2007; 79:41-49.
4. 2LEN/EDF guidelines: definition, classification and diagnosis of urticaria. Allergy 2008; 61:316-320.
5. 2LEN/EDF guidelines: management of urticaria. Allergy 2006; 61:321-331.
6. Eckman JA, Hamilton RG, Gober LM, et al. BasopphiI phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies. J Invest Dermatol 2008. [Epub ahead of print] This is a very interesting study reporting that both the autoantibody levels and functional basophil phenotype were stable in patients with active disease, whereas in disease remission a clear enhancement in basophil histamine release, independent of antibody presence, was observed.
7. Vonakis BM, Vasagar K, Gibbons SP Jr, et al. Basophil FcepsilonRl histamine release parallels expression of Src-homology 2-containing inositol phosphatases in chronic idiopathic urticaria J Allergy Clin Immunol 2007; 119:441-448. This study demonstrates bimodal response of basophils to anti-lgE activation in active CIU patients, thus dividing them into responders and nonresponders.
8. Vasagar K, Vonakis BM, Gober LM, et al. Evidence of in vivo basophil activation in chronic idiopathic urticaria Clin Exp Allergy 2006; 36:770-776.
9. Platzer MH, Grattan CE, Poulsen LK, Skov PS. Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients. Allergy 2005; 60:1152-1156.
10. Lourenço FD, Azor MH, Santos JC, et al. Activated status of basophils in chronic urticaria leads to interleukin-3 hyper-responsiveness and enhancement of histamine release induced by anti-lgE stimulus. Br J Dermatol 2008; 158:979-986.
11. Yasnowsky KM, Dreskin SC, Efaw B, et al. Chronic urticaria sera increase basophil CD203c expression. J Alergy Clin Immunol 2006; 117:1430-1434.
12. Frezzolini A, Provini A, Teofoli P, et al. Serum-induced basophil CD63 expression by means of a tricolour flow cytometric method for the in vitro diagnosis of chronic urticaria. Allergy 2006; 61:1071-1077.
13. Szegedi A, Irinyi B, Gál M, et al. Significant correlation between the CD63 assay and the histamine release assay in chronic urticaria. Br J Dermatol 2006; 155:67-75.
14. de Weck AL, Sanz ML, Gamboa PM, et al. Diagnostic tests based on human basophils: more potentials and perspectives man pitfalls, Int Arch Allergy Immunol 2008; 146:177-189.
15. Sabroe RA, Greaves MW. Chronic idiopathic urticaria with functional autoantibodies: 12 years on. Br J Dermatol 2006; 154:813-819.
16. Kaplan AP, Joseph K. Basophil secretion in chronic urticaria: autoantibodydependent or not? J Allergy Clin Immunol 2007; 120:729-730.
17. Vonakis BM, Saini SS. Syk-deficient basophils from donors with chronic idiopathic urticaria exhibit a spectrum of releasability. J Allergy Clin Immunol 2008; 121:262-264.
18. Dyke SM, Carey BS, Kaminski ER. Effect of stress on basophil function in chronic idiopathic urticaria. Clin Exp Allergy 2008; 38:86-92.
19. Asero R, Tedeschi A, Riboldi P, Cugno M. Plasma of patients with chronic urticaria shows signs of thrombin generation, and its intradermal injection causes wheal-and-flare reactions much more frequently than autologous serum. J Allergy Clin Immunol 2006; 117:1113-1117.
20. Asero R, Riboldi P, Tedeschi A, et al. Chronic urticaria: a disease at a crossroad between autoimmunity and coagulation. Autoimmun Rev 2007; 7:71-76. This is a recent review that discusses both the involvement of autoimmune mechanisms and activation of the extrinsic pathway of the coagulation cascade in the chronic urticaria pathogenesis.
21. Asero R, Tedeschi A, Coppola R, et al. Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria. J Allergy Clin Immunol 2007; 119:705-710.
22. Asero R, Tedeschi A, Riboldi P, et al. Coagulation cascade and fibrinolysis in patients with multiple-drug allergy syndrome. Ann Allergy Asthma Immunol 2008; 100:44-48.
23. Asero R, Tedeschi A, Riboldi P, et al. Severe chronic urticaria is associated with elevated plasma levels of D-dimer. Allergy 2008; 63:176-180.
24. Kasperska-Zajac A, Brzoza Z, Rogala B. Blood urokinase plasminogen activator system in chronic urticaria. Arch Dermatol Res 2007; 298:409-411.
25. Kasperska-Zajac A, Brzoza Z, Rogala B. Dehydroepiandrosterone and dehydroepiandrosterone sulphate in atopic allergy and chronic urticaria. Inflammation 2008; 31:141-145.
26. Kasperska-Zajac A, Brzoza Z, Rogala B. Circulating concentration of dehydroepiandrosterone sulfate (DHEA-S) in women suffering from chronic idiopathic urticaria in relation to their pre or postmenopausal status. Maturitas 2007; 58:211-215.
27. Kasperska-Zajac A, Brzoza Z, Rogala B. Plasma concentration of interleukin 6 (IL-6), and its relationship with circulating concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with chronic idiopathic urticaria. Cytokine 2007; 39:142-146.
28. Uguz F, Engin B, Yilmaz E. Axis I and axis II diagnoses in patients with chronic idiopathic urticaria. J Psychosom Res 2008; 64:225-229.
29. Engin B, Uguz F, Yilmaz E, et al. The levels of depression, anxiety and quality of life in patients with chronic idiopathic urticaria. J Eur Acad Dermatol Venereol 2008; 22:36-40. This study demonstrates significant impairment in both physical and psychological health in CIU patients and the importance of interdisciplinary approach - both dermatological and psychiatric - in this group of patients.
30. Ozkan M, Oflaz SB, Kocaman N, et al. Psychiatric morbidity and quality of life in patients with chronic idiopathic urticaria. Ann Allergy Asthma Immunol 2007; 99:29-33.
31. Buss YA, Garrelfs UC, Sticherling M. Chronic urticaria: which clinical parameters are pathogenetically relevant? A retrospective investigation of 339 patients. J Dtsch Dermatol Ges 2007; 5:22-29. This is a larger retrospective study stressing the importance of an individual approach to patients with chronic urticaria rather than performing initially exhaustive and expensive diagnostic tests.
32. Fromer L. Treatment options for the relief of chronic idiopathic urticaria symptoms. South Med J 2008; 101:186-192.
33. Gimenez-Arnau A, Pujol RM, lanosi S, et al. Rupatadine in the treatment of chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled multicentre study. Allergy 2007; 62:539-546.
34. Mullol J, Bousquet J, Bachert C, et al. Rupatadine in allergic rhinitis and chronic urticaria. Allergy 2008; 63 (Suppl 87):5-28.
35. Jaurequi I, Ferrer M, Montoro J, et al. Antihistamines in the treatment of chronic urticaria. J Invest Allegol Clin Immunol 2007; 17 (Suppl 2):41-52.
36. Caproni M, Volpi W, Giomi B, et al. Cellular adhesion molecules in chronic urticaria: modulation of serum levels occurs during levocetirizine treatment. Br J Dermatol 2006; 155:1270-1274.
37. Staubach P, Onnen K, Vonend A, et al. Autologous whole blood injections to patients with chronic urticaria and a positive autologous serum skin test: a placebo-controlled trial. Dermatology 2006; 212:150-159.
38. Bajaj AK, Saraswat A, Upadhyay A, et al. Autologous serum therapy in chronic urticaria: old wine in a new bottle. Indian J Dermatol Venereol Leprol 2008; 74:109-113.
39. Spector SL, Tan RA. Effect of omalizumab on patients with chronic urticaria. Ann Allergy Asthma Immunol 2007; 99:190-193.
40. Spector SL, Tan RA. Omalizumab also successful in chronic urticaria. J Allergy Clin Immunol 2008; 121:784-785.