Validation of 13C-acetic acid breath test by measuring effects of loperamide, morphine, mosapride, and itopride on gastric emptying in mice

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 10, 2008, Pages 1917-1922

  Matsumoto, Kenjiro ^a   Kimura, Hiroshi ^a   Tashima, Kimihito ^a   Uchida, Masayuki ^b   Horie, Syunji ^a  

^a JOSAI INTERNATIONAL UNIVERSITY   (Japan)

^b MEIJI DAIRIES CORPORATION   (Japan)

Author keywords

13C acetic acid; Breath test; Gastric emptying; Loperamide; Mosapride; Mouse

Indexed keywords

ACETIC ACID; CARBON 13; ITOPRIDE; LOPERAMIDE; MORPHINE; MOSAPRIDE CITRATE; NALOXONE; PHENOLSULFONPHTHALEIN; ANTIDIARRHEAL AGENT; ANTIEMETIC AGENT; ANTIULCER AGENT; BENZAMIDE DERIVATIVE; BENZYL DERIVATIVE; COLORING AGENT; DIAGNOSTIC AGENT; MORPHOLINE DERIVATIVE; MOSAPRIDE; NARCOTIC ANALGESIC AGENT; NARCOTIC ANTAGONIST;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BREATH ANALYSIS; DRUG EFFECT; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; STOMACH EMPTYING; STOMACH MOTILITY; VALIDATION PROCESS; ANIMAL; METHODOLOGY; REPRODUCIBILITY;

ACETIC ACID; ANALGESICS, OPIOID; ANIMALS; ANTI-ULCER AGENTS; ANTIDIARRHEALS; ANTIEMETICS; BENZAMIDES; BENZYL COMPOUNDS; BREATH TESTS; COLORING AGENTS; GASTRIC EMPTYING; LOPERAMIDE; MALE; MICE; MORPHINE; MORPHOLINES; NALOXONE; NARCOTIC ANTAGONISTS; PHENOLSULFONPHTHALEIN; REPRODUCIBILITY OF RESULTS;

EID: 53549091911     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.1917     Document Type: Article

References (15)

1. Ghoos Y. F., Maes B. D., Geypens B. J., Mys G., Hiele M. I., Rutgeerts P. J., Vantrappen G., Gastroenterology, 104, 1640-1647 (1993).
2. Whited K. L., Hornof W. J., Garcia T., Bohan D. C., Larson R. F., Raybould H. F., Neurogastroenterol. Motil., 16, 421-427 (2004).
3. Bennink R. J., De Jonge W. J., Symonds E. L., van den Wijngaard R. M., Spijkerboer A. L., Benninga M. A., Boeckxstaens G. E., J. Nucl. Med., 44, 1099-1104 (2003).
4. Schwarz R., Kaspar A., Seelig J., Künnecke B., Magn. Reson. Med., 48, 255-261 (2002).
5. Symonds E. L., Butler R. N., Omari T. I., Clin. Exp. Pharmacol. Physiol., 27, 671-675 (2000).
6. Symonds E., Butler R., Omari T., Ear. J. Clin. Invest., 32, 341-344 (2002).
7. Schoonjans R., Van Vlem B., Van Heddeghem N., Vandamme W., Vanholder R., Lameire N., Neurogastroenterol. Motil., 14, 287-293 (2002).
8. Uchida M., Endo N., Shimizu K., J. Pharmacol. Sci., 98, 388-395 (2005).
9. Uchida M., Shimizu K., Biol. Pharm. Bull., 30, 487-489 (2007).
10. Choi K. M., Zhu J., Stoltz G. J., Vernino S., Camilleri M., Szurszewski J. H., Gibbons S. J., Farrugia G., Am. J. Physiol. Gastrointest. Liver. Physiol., 293, 1039-1045 (2007).
11. De Smet B., Depoortere I., Moechars D., Swennen Q., Moreaux B., Cryns K., Tack J., Buyse J., Coulie B., Peeters T. L., J. Pharmacol. Exp. Ther., 316, 431-439 (2006).
12. Braden B., Lembcke B., Kuker W., Caspary W. F., Dig. Liver Dis., 39, 795-805 (2007).
13. Gaginella T. S., Bertko R. J., Kachur J. F., J. Pharmacol. Exp. Ther., 240,388-391 (1987).
14. Tsubouchi T., Saito T., Mizutani F., Yamauchi T., Iwanaga Y., J. Pharmacol. Exp. Ther., 306, 787-793 (2003).
15. Mine Y., Yoshikawa T., Oku S., Nagai R., Yoshida N., Hosoki K., J. Pharmacol. Exp. Ther., 283, 1000-1008 (1997).