Macrophages and platelets are the major source of protease nexin-1 in human atherosclerotic plaque

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 28, Issue 10, 2008, Pages 1844-1850

  Mansilla, Silvana ^a   Boulaftali, Yacine ^a   Venisse, Laurence ^a   Arocas, Véronique ^a   Meilhac, Olivier ^a   Michel, Jean Baptiste ^a,b   Jandrot Perrus, Martine ^a,c   Bouton, Marie Christine ^a  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c BICHAT HOSPITAL   (France)

Author keywords

Atherosclerosis; Inflammatory cells; Protease nexin 1; Thrombin

Indexed keywords

LIPOPOLYSACCHARIDE; PROTEASE NEXIN I; AMYLOID PRECURSOR PROTEIN; CELL SURFACE RECEPTOR; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEASE NEXINS; SERPINE1 PROTEIN, HUMAN;

ARTICLE; ATHEROSCLEROSIS; BLEEDING; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MONOCYTE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; THROMBOCYTE; THROMBOSIS; UPREGULATION; CAROTID ARTERY DISEASE; CAROTID ENDARTERECTOMY; CELL CULTURE; GENETICS; METABOLISM; PATHOLOGY; VASCULAR SMOOTH MUSCLE;

AMYLOID BETA-PROTEIN PRECURSOR; BLOOD PLATELETS; CAROTID ARTERY DISEASES; CELL DIFFERENTIATION; CELLS, CULTURED; ENDARTERECTOMY, CAROTID; HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MONOCYTES; MUSCLE, SMOOTH, VASCULAR; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTORS, CELL SURFACE; RNA, MESSENGER; UP-REGULATION;

EID: 53449087720     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.108.171389     Document Type: Article

References (29)

1. Smith EB, Crosbie L, Carey S. Prothrombin-related antigens in human aortic intima. Semin Thromb Hemost. 1996;22:347-350.
2. Kohler HP, Grant PJ. Plasminogen-activator inhibitor type 1 and coronary artery disease. N Engl J Med. 2000;342:1792-1801.
3. Eaton DL, Baker JB. Evidence that a variety of cultured cells secrete protease nexin and produce a distinct cytoplasmic serine protease-binding factor. J Cell Physiol. 1983;117:175-182.
4. Bouton MC, Venisse L, Richard B, Pouzet C, Arocas V, Jandrot-Perrus M. Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. Circ Res. 2007;100:1174-1181.
5. Bouton MC, Richard B, Rossignol P, Philippe M, Guillin MC, Michel JB, Jandrot-Perrus M. The serpin protease-nexin 1 is present in rat aortic smooth muscle cells and is upregulated in L-NAME hypertensive rats. Arterioscler Thromb Vasc Biol. 2003;23:142-147.
6. Baker JB, Low DA, Simmer RL, Cunningham DD. Protease-nexin: a cellular component that links thrombin and plasminogen activator and mediates their binding to cells. Cell. 1980;21:37-45.
7. Monard D. Tinkering with certain blood components can engender distinct functions in the nervous system. Perspect Dev Neurobiol. 1993;1:165-168.
8. Crisp RJ, Knauer DJ, Knauer MF. Roles of the heparin and low density lipid receptor-related protein-binding sites of protease nexin 1 (PN1) in urokinase-PN1 complex catabolism. The PN1 heparin-binding site mediates complex retention and degradation but not cell surface binding or internalization. J Biol Chem. 2000;275:19628-19637.
9. Muhl L, Nykjaer A, Wygrecka M, Monard D, Preissner KT, Kanse SM. Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP. Biochem J. 2007;404:191-196.
10. Rossignol P, Ho-Tin-Noe B, Vranckx R, Bouton MC, Meilhac O, Lijnen HR, Guillin MC, Michel JB, Angles-Cano E. Protease nexin-1 inhibits plasminogen activation-induced apoptosis of adherent cells. J Biol Chem. 2004;279:10346-10356.
11. Richard B, Pichon S, Arocas V, Venisse L, Berrou E, Bryckaert M, Jandrot-Perrus M, Bouton MC. The serpin protease nexin-1 regulates vascular smooth muscle cell adhesion, spreading, migration and response to thrombin. J Thromb Haemost. 2006;4:322-328.
12. Kanse SM, Chavakis T, Al-Fakhri N, Hersemeyer K, Monard D, Preissner KT. Reciprocal regulation of urokinase receptor (CD87)-mediated cell adhesion by plasminogen activator inhibitor-1 and protease nexin-1. J Cell Sci. 2004;117:477-485.
13. Leclercq A, Houard X, Loyau S, Philippe M, Sebbag U, Meilhac O, Michel JB. Topology of protease activities reflects atherothrombotic plaque complexity. Atherosclerosis. 2007;191:1-10.
14. Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W Jr. Rosenfeld ME, Schwartz CJ, Wagner WD, Wissler RW. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb Vasc Biol. 1995;15:1512-1531.
15. Klinkner AM, Waites CR, Kerns WD, Bugelski PJ. Evidence of foam cell and cholesterol crystal formation in macrophages incubated with oxidized LDL by fluorescence and electron microscopy. J Histochem Cytochem. 1995;43:1071-1078.
16. Lawrence D, Strandberg L, Grundstrom T, Ny T. Purification of active human plasminogen activator inhibitor 1 from Escherichia coli. Comparison with natural and recombinant forms purified from eucaryotic cells. Eur J Biochem. 1989;186:523-533.
17. Evans DL, McGrogan M, Scott RW, Carrell RW. Protease specificity and heparin binding and activation of recombinant protease nexin I. J Biol Chem. 1991;266:22307-22312.
18. Whisstock JC, Bottomley SP. Molecular gymnastics: serpin structure, folding and misfolding. Curr Opin Struct Biol. 2006;16:761-768.
19. Essex DW, Miller A, Swiatkowska M, Feinman RD. Protein disulfide isomerase catalyzes the formation of disulfide-linked complexes of vitronectin with thrombin-antithrombin. Biochemistry. 1999;38:10398-10405.
20. Gronke RS, Knauer DJ, Veeraraghavan S, Baker JB. A form of protease nexin I is expressed on the platelet surface during platelet activation. Blood. 1989;73:472-478.
21. Moreau M, Brocheriou I, Petit L, Ninio E, Chapman MJ, Rouis M. Interleukin-8 mediates downregulation of tissue inhibitor of metalloproteinase-1 expression in cholesterol-loaded human macrophages: relevance to stability of atherosclerotic plaque. Circulation. 1999; 99:420-426.
22. Suzuki T, Hashimoto S, Toyoda N, Nagai S, Yamazaki N, Dong HY, Sakai J, Yamashita T, Nukiwa T, Matsushima K. Comprehensive gene expression profile of LPS-stimulated human monocytes by SAGE. Blood. 2000;96:2584-2591.
23. Gordon S. Alternative activation of macrophages. Nat Rev Immunol. 2003;3:23-35.
24. Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity. 2005;23:344-346.
25. Murer V, Spetz JF, Hengst U, Altrogge LM, de Agostini A, Monard D. Male fertility defects in mice lacking the serine protease inhibitor protease nexin-1. Proc Natl Acad Sci U S A. 2001;98:3029-3033.
26. Buchholz M, Biebl A, Neesse A, Wagner M, Iwamura T, Leder G, Adler G, Gress TM. SERPINE2 (protease nexin I) promotes extracellular matrix production and local invasion of pancreatic tumors in vivo. Cancer Res. 2003;63:4945-4951.
27. Strehlow D, Jelaska A, Strehlow K, Korn JH. A potential role for protease nexin 1 overexpression in the pathogenesis of scleroderma. J Clin Invest. 1999;103:1179-1190.
28. Bedard J, Brule S, Price CA, Silversides DW, Lussier JG. Serine protease inhibitor-E2 (SERPINE2) is differentially expressed in granulosa cells of dominant follicle in cattle. Mol Reprod Dev. 2003;64:152-165.
29. Yu DW, Yang T, Sonoda T, Gaffney K, Jensen PJ, Dooley T, Ledbetter S, Freedberg JM, Lavker R, Sun TT. Message of nexin I, a serine protease inhibitor, is accumulated in the follicular papilla during anagen of the hair cycle. J Cell Sci. 1995;108(Pt 12):3867-3874.