Pancreatic islet fibrosis in rock hyraxes (Procavia capensis), part 1: Case histories, clinical pathology, and epizootiology

Journal of Zoo and Wildlife Medicine

Volumn 35, Issue 3, 2004, Pages 361-369

  Gamble, Kathryn C ^a,c   Garner, Michael M ^b   Krause, Laura ^a   Alvarado, Thomas P ^a  

^a Dallas Zoological Society   (United States)

^b NORTHWEST ZOOPATH   (United States)

^c LINCOLN PARK ZOO   (United States)

Author keywords

Diabetes mellitus; Islet of Langerhans; Pancreas; Pathology; Procavia capensis; Rock hyrax

Indexed keywords

ANIMALIA; PROCAVIA CAPENSIS; PROCAVIIDAE;

EID: 5344262424     PISSN: 10427260     EISSN: None     Source Type: Journal    
DOI: 10.1638/02-061     Document Type: Review

References (38)

1. Björnhag, G., G. Becker, C. Buchholz, and W. von Engelhardt. 1994. The gastrointestinal tract of the rock hyrax (Procavia habessinica). 1. Morphology and motility patterns of the tract. Comp. Biochem. Physiol. 109A: 649-653.
2. Björnhag, G., G. Becker, C. Buchholz, and W. von Engelhardt. 1995. The gastrointestinal tract of the rock hyrax (Procavia habessinica). 2. Fluid flow, production of short chain fatty acids and absorption of water and electrolytes. Comp. Biochem. Physiol. 111A: 433-438.
3. Bopegamage, S. A., and A. Petrovicova. 1994. In vitro infection of mouse pancreatic islet cells with Coxsackie virus. Acta Virol. 38: 251-255.
4. Eloff, A. K., and W. Van Hoven. 1985. Volatile fatty acid production in the hindgut of Procavia capensis. Comp. Biochem. Physiol. 80A: 291-295.
5. Fairall, N., A. K. Eloff, and I. S. McNairn. 1983. Integration of metabolism and digestion in the hyrax. S. Afr. J. Anim. Sci. 13: 79-80.
6. Fell, B. F., L. J. Farmer, C. Farquharson, I. Bremner, and D. S. Graca. 1985. Observations on the pancreas of cattle deficient in copper. J. Comp. Pathol. 95: 573-599.
7. Fleeman, L. M., and J. S. Rand. 2003. Evaluation of day-to-day variability of serial blood glucose concentration curves in diabetic dogs. J. Am Vet. Med. Assoc. 222: 317-321.
8. Frye, F. L. 1982. Iron storage disease (hemosiderosis) in an African rock hyrax (Procavia capensis). J. Zoo. Anim. Med. 13: 152-156.
9. Gabrielson, K. L., R. L. Remillard, and D. L. Huso. 1996. Zinc toxicity with pancreatic acinar necrosis in piglets receiving total parenteral nutrition. Vet. Pathol. 33: 692-696.
10. Garner, M. M., K. C. Gamble, J. T. Raymond, T. P. Alvarado, and J. W. Wojcieszyn. In press. Pancreatic islet fibrosis in rock hyrax (Procavia capensis): pathology, immunohistochemistry, and electron microscopy. J. Zoo Wildl. Med. 35: 280-291.
11. Gerich, J. E. 1990. Role of somatostatin and its analogues in the pathogenesis and treatment of diabetes mellitus. Metabolism 39(Suppl. 2): 52-54.
12. Glick-Bauer, M., and E. S. Dierenfeld. 1999. Dietary intake and digestion in rock hyrax (Procavia capensis) at the Prospect Park Wildlife Center. Zool. Gart. 69: 293-300.
13. Graham, T. W., C. A. Holmberg, C. L. Keen, V. K. Thurmond, and M. S. Cleeg. 1988. A pathologic and toxicologic evaluation of veal calves fed large amounts of zinc. Vet. Pathol. 25: 484-491.
14. Griner, L. 1986. Hyraxes (Hyracoidea). In: Fowler, M. E. (ed). Zoo & Wild Animal Medicine, 2nd ed. W. B. Saunders Co., Philadelphia, Pennsylvania. Pp. 600-603.
15. Grubin, C. E., T. Daniels, B. Toivola, M. Landin-Olsson, W. A. Hagopian, L. Li, A. E. Karlsen, E. Boel, B. Michelsen, and Å. Lernmark. 1994. A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 37: 344-350.
16. Haines, B. M., and W. J. Penhale. 1985. Autoantibodies to pancreatic islet cells in canine diabetes mellitus. Vet. Immunol. Immunopathol. 8: 149-156.
17. Haines, D. M. 1986. A re-examination of islet cell cytoplasmic antibodies in diabetec dogs. Vet. Immunol. Immunopathol. 11: 225-233.
18. Hampe, C. S., P. Lundgren, T. L. Daniels, L. P. Hammerle, S. M. Marcovina, and Å. Lernmark. 2001. A novel monoclonal antibody specific for the N-terminal end of GAD65. J. Neuroimmunol. 113: 63-71.
19. Hempe, C. S., E. Örtqvist, B. Persson, D. B. Schranz, and Å Lernmark. 1999. Glutamate decarboxylase (GAD) autoantibody epitope shift during the first year of type I diabetes. Horm. Metab. Res. 31: 553-557.
20. Howard, C. F., and M. Yasuda. 1990. Diabetes mellitus in non-human primates: recent research advances and current husbandry practices. J. Med. Primatol. 19: 609-625.
21. International Species Inventory System. 1999. Physiologic data reference values for hyrax (Procavia capensis). International Species Inventory System, Apple Valley, Minnesota.
22. Jubb, K. V. F. 1993. The pancreas. In: Jubb, K. V. F, P. C. Kennedy, and N. Palmer (eds.). Pathology of Domestic Animals, 4th ed., vol 2. Academic Press, Inc., San Diego, California. P. 407.
23. Kazacos, E. A., and J. F. Van Vleet. 1989. Sequential ultrastructural changes of the pancreas in zinc toxicosis in ducklings. Am. J. Pathol. 134: 581-585.
24. Leon, B. 1980. Fermentation and the production of volatile fatty acids in the alimentary tract of the rock hyrax (Procavia capensis). Comp. Biochem. Physiol. 65A: 411-420.
25. Lloyd, M. L., J. B. Susa, J. A. Pelto, and A. Savage. 1995. Gestational diabetes mellitus in a white-faced saki (Pithecia pithecia). J. Zoo Wildl. Med. 26: 76-81.
26. Longnecker, D. S. 1977. Environmental factors and diseases of the pancreas. Environ. Health Perspect. 20: 105-112.
27. Longnecker, D. S. 1982. Pathology and pathogenesis of diseases of the pancreas. Am. J. Pathol. 107: 103-121.
28. Nelson, L., S. Turkel, I. Shulman, and S. Gabbe. 1977. Pancreatic-islet fibrosis in young infants of diabetic mothers. Lancet 13: 362-363.
29. Nelson, R. W., S. M. Griffey, E. C. Feldman, and S. L. Ford. 1999. Transient clinical diabetes mellitus in cats (1989-1991). J. Vet. Int. Med. 13: 28-35.
30. Noda, A., T. Masegi, T. Yanal, H. Sakai, Y. Hukumoto, H. Dalmaru, T. Matsumoto, K. Murata, N. Hama, S. Kawakami, E. Saitou, N. Kawai, and A. Ishida. 1998. Pathological research of 80 Cape hyraxes (Procavia capensis). Abstr. Jpn. Soc. Zoo. Wildl. Med. Annu. Meet. 4: 63.
31. Rübsamen, K., I. D. Hume, and W. von Engelhardt. 1982. Physiology of the rock hyrax. Comp. Biochem. Physiol. 72A: 271-277.
32. Sasaki, M., T. Arai, Y. Oki, and K. Komeda. 1991. An ultrastructural study on the pancreatic islet B cells in diabetic herbivorous voles. Vet. Res. Commun. 15: 205-210.
33. Shaw, D. P., J. E. Collins, and M. J. Murphy. 1991. Pancreatic fibrosis associated with zinc toxicosis in a dog. J. Vet. Diag. Invest. 3: 80-81.
34. Smith, B. L., and P. P. Embling. 1993. Sequential changes in the development of the pancreatic lesion of zinc toxicosis in sheep. Vet. Pathol. 30: 242-247.
35. Tomita, T., P. Visser, S. Friesen, and V. Doull. 1984. Cortisone-induced islet hyperplasia in hamsters. Virchows Arch. Cell Pathol. 45: 85-95.
36. Wallach, J. D., K. Lagarde, and M. S. Silberman. 1977. Hematological and serum chemistry values of the rock hyrax (Procavia capensis). J. Zoo. Anim. Med. 8: 30-34.
37. Ye, X., A. C. Scallet, and R. I. Carp. 1997. The 139 H scrapie agent produces hypothalamic neurotoxicity and pancreatic islet histopathology: electron microscopic studies. Neurotoxicology 18: 533-546.
38. Zootrition software. 1999. Wildlife Conservation Society, Bronx, New York.