Zinc toxicity with pancreatic acinar necrosis in piglets receiving total patenteral nutrition

Veterinary Pathology

Volumn 33, Issue 6, 1996, Pages 692-696

  Gabrielson, K L ^b   Remillard, R L ^b   Huso, D L ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NONE

Author keywords

Acinar necrosis; Pancreas; Swine; Total parenteral nutrition (TPN); Zinc toxicity

Indexed keywords

SUS SCROFA;

ZINC;

ANIMAL; ANIMAL DISEASE; ARTICLE; ATROPHY; CHEMISTRY; DRUG EFFECT; EPITHELIUM; FEMALE; FIBROSIS; INTESTINE; LIVER; MALE; MICROVILLUS; NECROSIS; PANCREAS; PANCREAS DISEASE; PATHOLOGY; RANDOMIZATION; SWINE; SWINE DISEASE; TOTAL PARENTERAL NUTRITION; ULTRASTRUCTURE;

ANIMALS; ATROPHY; EPITHELIUM; FEMALE; FIBROSIS; INTESTINES; LIVER; MALE; MICROVILLI; NECROSIS; PANCREAS; PANCREATIC DISEASES; PARENTERAL NUTRITION, TOTAL; RANDOM ALLOCATION; SWINE; SWINE DISEASES; ZINC;

EID: 0030278879     PISSN: 03009858     EISSN: None     Source Type: Journal    
DOI: 10.1177/030098589603300608     Document Type: Article

References (14)

1. Allen JG, Masters HG, Peet RL, Mullins KR, Lewis RD, Skirrow SZ, Fry J: Zinc toxicity in ruminants. J Comp Pathol 93:363-377, 1983
2. Cousins RJ: Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol Rev 65:238-309, 1985
3. Fell BF, Farmer LJ, Farquharson C, Bremner, I, Graca DS: Observations on the pancreas of cattle deficient in copper. J Comp Pathol 95:573-590, 1985
4. Graham TW, Holmberg CA, Keen CL, Thurmond MC, Clegg MS: A pathologic and toxicologic evaluation of veal calves fed large amounts of zinc. Vet Pathol 25:484-491, 1988
5. Grimmett RER, McIntosh IG, Wall EM, Hopkirk CSM: Chronic zinc-poisoning of pigs: results of experimental feeding of pure zinc lactate. NZJ Agric 54:216-223, 1937
6. Kazacos EA, Van Vleet JF: Sequential ultrastructural changes of the pancreas in zinc toxicosis in ducklings. Am J Pathol 134:581-595, 1989
7. Longnecker DS: Pathology and pathogenesis of diseases of the pancreas. Am J Pathol 107:103-121, 1982
8. National Academy of Sciences: Mineral Tolerance of Domestic Animals. National Academy of Sciences, Washington, DC, 1980
9. National Research Council: Nutrient Requirements of Swine, 9th ed. National Academy Press, Washington, DC, 1988.
10. Pekas JC: Zinc 65 metabolism: gastrointestinal secretion by the pig. Am J Physiol 211:407-413, 1966
11. Pritchard GC, Lewis G. Wells GAH, Stopforth A: Zinc toxicity, copper deficiency and anaemia in swill-fed pigs. Vet Rec 117:545-548, 1985
12. Rebar AH, Van Vleet JF: Ultrastructural changes in the pancreata of selenium-vitamin E-deacient chicks. Vet Pathol 14:629-642, 1977
13. Shaw DP, Collins JE, Murphy MJ: Pancreatic fibrosis associated with zinc toxicosis in a dog. J Vet Diagn Invest 3:80-81, 1991
14. Smith BL, Embling PP: Sequential changes in the development of the pancreatic lesion of zinc toxicosis in sheep. Vet Pathol 30:242-247, 1993