Thymectomy should be the first choice in the protection of diabetes-prone BB rats for breeding purposes

Laboratory Animals

Volumn 38, Issue 4, 2004, Pages 371-375

  Visser, Jeroen ^a   Klatter, Flip ^a   Hillebrands, Jan Luuk ^a   Jansen, Ar ^a   Vijfschaft, Lucas ^a   Rozing, Jan ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Breeding performance; Diabetes prevention; Diabetes prone BB rats; Offspring; Thymectomy

Indexed keywords

INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANIMAL WELLBEING; ARTICLE; BREEDING; CONVALESCENCE; FEMALE; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INTERMETHOD COMPARISON; LYMPHOCYTE TRANSFER; MALE; NONHUMAN; PREGNANCY RATE; PRIMARY PREVENTION; PROGENY; RAT; RAT STRAIN; SAFETY; T LYMPHOCYTE; THYMECTOMY; TREATMENT OUTCOME; WELLBEING;

ANIMALS; BREEDING; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; FEMALE; LITTER SIZE; MALE; PREGNANCY; RATS; RATS, INBRED BB; SPECIFIC PATHOGEN-FREE ORGANISMS; THYMECTOMY; THYMUS GLAND;

ANIMALIA;

EID: 5344254580     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/0023677041958936     Document Type: Article

References (4)

1. Burstein D, Mordes JP, Greiner DL, Stein D, Nakamura N, Handler ES, Rossini AA (1989) Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection. Diabetes 38, 24-30
2. Like AA, Kislaukis E, Williams RM, Rossini AA (1982) Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/w rat. Science 216, 644-6
3. Mordes JP, Bortell R, Groen H, Guberski DL, Rossini AA, Greiner D (2001) Autoimmune diabetes mellitus in the BB rat. In: Animal Models for Autoimmune Diabetes (Sima AAF, Shafrir E, eds). Amsterdam: Harwood Academic Publishers, pp 1-41
4. Visser J, Klatter F, Vis L, Groen H, Strubbe J, Rozing J (2003) Long-term prophylactic insulin treatment can prevent spontaneous diabetes development and thyroiditis development in the diabetes prone BB rat, while short-term treatment is ineffective. European Journal of Endocrinology 149, 223-9